Brucellosis (Malta Fever)

Subscribe to Selected New Research on Brucellosis

1536 relevant articles (84 outcomes, 145 trials/studies) found for this Disease

Description: Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.

Also Known As:

Malta Fever; Undulant Fever; Brucelloses; Fever, Malta; Fever, Undulant; Fevers, Undulant; Undulant Fevers

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses

Bacterial Infections: 6830

Gram-Negative Bacterial Infections: 240

Brucellosis: 1536

Bovine Brucellosis: 101

Related Diseases

1.	Infection
2.	Plague (Bubonic Plague)
3.	Anthrax
4.	Fever (Fevers)
5.	Leptospirosis

Experts

1.	Smits, Henk L: 6 articles (04/2007 - 07/2003)
2.	Colmenero, J D: 5 articles (04/2007 - 02/2001)
3.	Abdoel, Theresia H: 5 articles (04/2007 - 11/2003)
4.	Hajilooi, Mehrdad: 4 articles (07/2007 - 01/2006)
5.	Solera, Javier: 4 articles (05/2006 - 11/2003)
6.	Gamazo, C: 4 articles (03/2004 - 07/2001)
7.	Baldi, Pablo C: 4 articles (05/2003 - 03/2002)
8.	Delpino, M Victoria: 4 articles (05/2003 - 03/2002)
9.	Rafiei, Alireza: 3 articles (07/2007 - 01/2006)
10.	Irache, J M: 3 articles (03/2004 - 07/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brucellosis:

1.	Rifampin (Rifampicin)FDA LinkGeneric 01/12/1984 - "Rifampin, which exhibits good intracellular diffusion and in vitro bactericidal activity on brucella, is effective in experimental brucellosis in mice, without selection of resistant strains. " 01/01/1990 - "It is evident from this study that the treatment with rifampicin alone is not as effective in brucellosis as it is when given with another appropriate drug." 12/01/2005 - "This study shows that the Republic of Korea is no longer free of human brucellosis, Brucella abortus biotype 1. We reviewed the patients' characteristics and serologic data during the one-year follow up period, and we also discuss on the efficacy and side effects of the rifampin and doxycyline regimen used for the treatment of human brucellosis." 08/01/2008 - "R Rifampicin resistance of Brucella melitensis by rpoB gene analysis has not yet been performed in Turkey, where brucellosis is endemic. " 12/01/2001 - "Consideration should be given to prohibiting the routine use of rifampicin for the treatment of brucellosis." Order ALL the reference details at left...
2.	Doxycycline (Vibramycin)FDA LinkGeneric 05/21/1994 - "[Meta-analysis of the efficacy of the combination of +rifampicin and doxycycline in the treatment of human brucellosis]" 12/01/2005 - "METHODS: Four patients with brucellosis developed yellow-brown discolouration of teeth following a 30-45 day course of doxycycline therapy during summer at a dose of 200mg/day. " 12/01/2005 - "BACKGROUND: Doxycycline is the most effective antibiotic for managing brucellosis. " 04/14/2005 - "We discuss the relationship between brucellosis, AIH, and hepatotoxicity of doxycycline. " 04/14/2005 - "Only one case of AIH probably caused by doxycycline and brucellosis was reported. " Order ALL the reference details at left...
3.	Streptomycin (Streptomycin Sulfate)FDA Link 07/01/1989 - "Efficacy of various treatment regimens, using liposomal streptomycin in cows with brucellosis." 04/01/1950 - "Studies on the effect of streptomycin in experimental brucellosis in guinea pigs." 07/01/1994 - "Streptomycin at this dose was previously documented to be ineffective against murine brucellosis. " 05/01/1990 - "The effectiveness of treating human brucellosis caused by Brucella melitensis with a 6-week course of doxcycline plus streptomycin for 2 of those weeks was analyzed by a multicenter prospective study of 139 patients. " 08/01/1954 - "[Treatment of brucellosis with streptomycin; preliminary data.]" Order ALL the reference details at left...
4.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 02/01/1986 - "[Treatment of osteoarticular brucellosis with trimethoprim-sulfamethoxazole. " 05/31/1975 - "Co-trimoxazole in chronic brucellosis: a two-year follow-up study." 05/30/1975 - "[Trimethoprim-sulfamethoxazole combination in the treatment of brucellosis (author's transl)]" 05/30/1974 - "[Trimethoprim-sulfamethoxazole (TM-SMZ) combination in the treatment of brucellosis]" 11/01/1973 - "Trimethoprim-sulfamethoxazole in brucellosis." Order ALL the reference details at left...
5.	AntigensIBA 01/01/1991 - "The administration of LBA, whose active principle is a polysaccharide and protein complex, reduced high sensitivity to brucellar antigen and raised the functional activity of neutrophilic granulocytes and T-lymphocytes, improved the late results of the treatment of patients with brucellosis running its course with pronounced sensitization." 01/01/2002 - "SIGNIFICANCE AND IMPACT OF THE STUDY: This study proposes an improved antigen for the CF test for the epidemiological survey of animal brucellosis. " 01/01/1987 - "An improved antigen is described for use in the serodiagnosis of canine brucellosis. " 01/01/1982 - "[Course of chronic brucellosis in mice is not improved by administration of a vaccinal antigen]" 03/10/2006 - "HS-PEC microparticles can be used as a safe vaccine against brucellosis in rams, but further studies using higher doses of antigens are necessary to exploit their full potential for the prophylaxis of brucellosis in sheep." Order ALL the reference details at left...
6.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2006 - "We retrospectively reviewed 10 patients with spinal brucellosis of the thoracic and lumbar spine who were treated successfully with a combination of surgery and antibiotics. " 01/01/2009 - "Brucella spp. replicate and survive in lympho-proliferative tissues and cells, thus effective treatment of brucellosis requires the combined and long term use of intracellularly active antibiotics. " 01/01/2002 - "[Efficacy of some new antibiotics in treating experimental brucellosis]" 06/01/1956 - " II. Behavior of some immunity indices in brucellosis cured with antibiotics.]" 07/01/1965 - "[Bacteria antagonistic to Brucella and trials of obtaining new specific antibiotics against the brucellosis of domestic animals]" Order ALL the reference details at left...
7.	VaccinesIBA 12/01/1998 - "WHO consultation on the development of new/improved brucellosis vaccines. " 09/01/1971 - "[Comparison of the efficacy of 2 attenuated live vaccines against caprine brucellosis in Mexico]" 10/01/2006 - "Previous studies have suggested that currently available brucellosis vaccines induce poor or no protection in elk (Cervus elaphus nelsoni). " 05/01/1998 - "Venezuelan field trials of vaccines against brucellosis in swine." 11/01/1985 - "The study of different doses of chemical brucellosis vaccine (0.5 mg, 0.75 mg and 1 mg), used for the booster immunization of persons who had received primary immunization with chemical and live brucellosis vaccines, revealed that the characteristics of its antigenic potency were somewhat higher after primary immunization with the live vaccine. " Order ALL the reference details at left...
8.	AntibodiesIBA 10/01/1984 - "Low-molecular glucopeptide stimulated protection against brucellosis without the accumulation of complete antibodies and the increase of skin sensitivity. " 07/01/2004 - "CONCLUSION: In this study, we conclude that brucellosis has peculiar epidemiologic characteristics in blood banks that participated in this research; therefore it is highly recommended to perform screening tests such as BR, SAM, and 2ME to identified anti-Brucella antibodies in the sera of effective blood donors." 02/01/2002 - "For this reason, a validation study was performed in which three indirect enzyme-linked immunosorbent assays (ELISAs), the CFT and the SAT were compared using a panel of sera from brucellosis-free cattle, sera from experimentally infected cattle, and sera from cattle experimentally infected with bacteria which are known to induce cross-reactive antibodies (Pasteurella, Salmonella, Yersinia, and Escherichia). " 09/01/1999 - "Previous studies have shown that the detection of antibodies to an 18-kDa cytoplasmic protein of Brucella spp. is useful for the diagnosis of human and animal brucellosis. " 01/01/1996 - "In a field study, 66.7% of the 174 serum samples from cattle presenting false positive serological reactions showed anti-YOPs antibodies whereas only 10% of 454 sera, classified negative by the brucellosis screening tests, showed anti-YOPs antibodies. " Order ALL the reference details at left...
9.	Immunoglobulin G (IgG)IBA 11/14/2007 - "Furthermore, escheriosome entrapped rL7/L12 protein elicited high IgG2a isotype response suggestive of its relevance in imparting protection against brucellosis in mice. " 06/01/2009 - "The prediction is that iELISA based on broadly cross-reacting anti-dolphin IgG antibody would be a reliable test for the diagnosis of brucellosis in odontocetes, including families not covered in this study." 01/01/2009 - "CONCLUSION: In acute brucellosis, IgG2a response (indicative of a Th1 response) was found to be significantly dominant over IgG1 response (indicative of Th2 response) (P < 0.001)." 11/01/2008 - "IgG S-LPS avidity results in patients with brucellosis history were significantly higher (always over 84%) than in patients without brucellosis history (from 48.0% in the initial sera to 81% ten months later) (p<0.001). " 12/01/2003 - "IgG antibody in addition to seroagglutinating antibody titers are useful for serological followup of patients with brucellosis." Order ALL the reference details at left...
10.	Levamisole (Decaris)FDA Link 01/01/1980 - "Our results suggest that levamisole might prove to be beneficial in the treatment of chronic brucellosis." 01/01/1987 - "A study was made of the comparative efficacy of levamisole (a controlled method) and vaccinotherapy in combined treatment of 97 patients with chronic brucellosis. " 01/01/1986 - "The clinical efficacy of levamisole was compared to that of vaccine in a controlled trial of a combined treatment performed in 311 patients with acute and subacute brucellosis. " 06/01/1983 - "Conventional therapy and levamisole in the management of chronic brucellosis." 03/01/2005 - "CONCLUSION: In chronic brucellosis, levamisole administered as a supplement concomitantly with conventional antibiotic therapy has no immunostimulating effect on the basis of the lymphocyte subgroups ratios measured and the ability of phagocytosis in the present study. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/01/2004 - "Early diagnosis is important and prompt antibrucellar chemotherapy is effective in most cases, but prolonged follow up is necessary in all patients with spinal brucellosis." 01/01/1957 - "[Clinical & therapeutic studies of 250 cases of brucellosis on the basis of the present-day status of chemotherapy.]" 03/26/1953 - "[Enzymatic studies on the change of form of Brucella abortus as contribution to chemotherapy of brucellosis.]" 02/01/2008 - "Forty years after active drug therapy was defined, there is no optimum antibiotic therapy for brucellosis due to relatively high rates of relapse and treatment failure. " 08/01/2007 - "We carried out the chemotherapy for both ALL and brucellosis simultaneously. " Order ALL the reference details at left...
2.	Induced Abortion (Induced Abortions) 01/01/2009 - "This study was undertaken to investigate the seroprevalence of brucellosis in unvaccinated sheep from the flocks having previous abortion cases in Kars and around, Turkey and to compare the efficacy of each serological test used. " 01/01/2005 - "In the present study, we investigated abortion induced by Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in a mouse model. " 01/01/1979 - "When the importance of a herd increase sanitation of tuberculosis in infected herds is less readily achieved and brucellosis abortion rate increases. " Order ALL the reference details at left...
3.	Microspheres (Microsphere) 05/01/2007 - "canis using hot saline, coated on to latex beads and their usefulness in the serological diagnosis of canine brucellosis was examined. " 06/01/2004 - "OBJECTIVES: The intracellular antibiotic efficiency of gentamicin-loaded microspheres in the context of Brucella-infected murine monocytes was examined in vitro with a view to developing improved therapies for the treatment of brucellosis. " 05/01/2007 - "Although these results suggest that our method in which crude hot saline extracted antigens are coated on to latex beads would be useful in the serological diagnosis of canine brucellosis, we need further investigation using more serum samples to confirm the usefulness of our method." 09/01/2006 - "CONCLUSIONS: Altogether, these results suggest that 502H and 75:25H microspheres are suitable carriers for gentamicin targeting inside human macrophages and thus for brucellosis treatment." Order ALL the reference details at left...
4.	Injections 01/01/1976 - "The different forms of chronic brucellosis have been improved and well stabilized in the proportion of 75% by repeated injections of a vaccine consisting of suspensions of heat-killed B. " 05/01/1983 - "After brucellosis patients received the injections of therapeutic vaccine, their levels of IgG and IgG1 increased, while the concentration of IgG3 decreased and that of IgG2 and IgG4 remained unchanged." 06/01/1957 - "[Treatment of brucellosis by intracutaneous vaccine injections and by vaccine combined with antibiotics.]" Order ALL the reference details at left...
5.	Immunotherapy 11/01/1994 - "Immunotherapy in chronic brucellosis. " 04/15/1952 - "[Associated antibiotic and immunotherapy of brucellosis.]" 01/27/1951 - "[Chloramphenicol and combined chloramphenicol-immunotherapy in the treatment of brucellosis.]" 11/01/1994 - "A significant improvement of symptoms as well as production of leukocyte migration inhibition against brucella antigens were noted in both groups 1 and 2, in contrast to group 3. This response to treatment was however greater in group 1. These findings demonstrate that immunotherapy resulted in both clinical and immunological improvement and that interferon seems to be a more promising therapeutic approach of chronic brucellosis." Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Brucellosis

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 84 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>