|2.||HIV Infections (HIV Infection)
|3.||Communicable Diseases (Infectious Diseases)
|4.||Chronic Hepatitis (Chronic Active Hepatitis)
|5.||Plague (Bubonic Plague)
|1.||Smits, Henk L: 12 articles (02/2012 - 07/2003)|
|2.||Sriranganathan, Nammalwar: 10 articles (01/2015 - 12/2002)|
|3.||Solera, Javier: 10 articles (12/2014 - 11/2003)|
|4.||Giambartolomei, Guillermo H: 10 articles (04/2013 - 07/2002)|
|5.||Abdoel, Theresia H: 10 articles (02/2012 - 11/2003)|
|6.||Cassataro, Juliana: 10 articles (09/2011 - 03/2002)|
|7.||Blasco, J M: 9 articles (08/2015 - 07/2001)|
|8.||Pappas, Georgios: 9 articles (12/2014 - 11/2004)|
|9.||Nielsen, K: 9 articles (05/2011 - 09/2000)|
|10.||Fossati, Carlos A: 9 articles (01/2011 - 03/2002)|
|1.||Rifampin (Rifampicin)FDA LinkGeneric
01/12/1984 - "Rifampin, which exhibits good intracellular diffusion and in vitro bactericidal activity on brucella, is effective in experimental brucellosis in mice, without selection of resistant strains. "
01/01/1990 - "It is evident from this study that the treatment with rifampicin alone is not as effective in brucellosis as it is when given with another appropriate drug."
04/01/2013 - "Rifampin is considered the mainstay of treatment of brucellosis during pregnancy, in various combinations. "
12/01/2005 - "This study shows that the Republic of Korea is no longer free of human brucellosis, Brucella abortus biotype 1. We reviewed the patients' characteristics and serologic data during the one-year follow up period, and we also discuss on the efficacy and side effects of the rifampin and doxycyline regimen used for the treatment of human brucellosis."
01/01/2015 - "abortus strains isolated from cattle in Brazil were sensitive to the antimicrobials commonly used for the treatment of human brucellosis; however, a considerable proportion of strains showed reduced susceptibility to rifampicin and two strains were considered multidrug resistant. "
|2.||Doxycycline (Vibramycin)FDA LinkGeneric
02/01/2011 - "The nanoparticulate formulation of lipomer doxycycline hydrochloride (lipomer DH) has been synthesized for the treatment of Brucellosis to increase efficacy of the drug. "
05/21/1994 - "[Meta-analysis of the efficacy of the combination of +rifampicin and doxycycline in the treatment of human brucellosis]."
10/01/2013 - "Randomized controlled trials demonstrate that optimal treatment for human brucellosis consists of doxycycline and an aminoglycoside. "
01/01/2012 - "Although the preferred treatment in uncomplicated human brucellosis is doxycycline-aminoglycoside combination, other treatments based on oral regimens or monotherapy should not be rejected until they are better studied. "
12/01/2005 - "Four patients with brucellosis developed yellow-brown discolouration of teeth following a 30-45 day course of doxycycline therapy during summer at a dose of 200mg/day. "
10/01/2010 - "Data are taken from studies on the immunogenic activity and epizootic efficacy of vaccines against brucellosis in animals, which made it possible, in the final analysis, to regard these preparations as highly important for brucellosis prevention. "
01/01/2015 - "Respondents perceived improvement in human resources in terms of training and recruiting more health personnel, facilitation of the necessary activities such as sensitization of the communities about brucellosis, and provision of vaccines and diagnostic tests as very important in the integration process in the communities. "
06/01/2011 - "While several new vaccines that induced weak or no responses on serologic agglutination tests were identified by experiments in guinea pigs and cattle, a large body of experimental and field studies suggested that the smooth-rough strain SR82 vaccine combined the desired weak agglutination test responses with comparatively higher efficacy against brucellosis. "
07/15/2013 - "Consequently, there is a need for new safe and effective brucellosis vaccines to be developed. "
01/01/2010 - "While several animal vaccines are available, there is no effective and safe vaccine for prevention of brucellosis in humans. "
|4.||Streptomycin (Streptomycin Sulfate)FDA Link
07/01/1989 - "Efficacy of various treatment regimens, using liposomal streptomycin in cows with brucellosis."
04/01/1950 - "Studies on the effect of streptomycin in experimental brucellosis in guinea pigs."
07/01/1994 - "Streptomycin at this dose was previously documented to be ineffective against murine brucellosis. "
05/01/1990 - "The effectiveness of treating human brucellosis caused by Brucella melitensis with a 6-week course of doxcycline plus streptomycin for 2 of those weeks was analyzed by a multicenter prospective study of 139 patients. "
08/01/1954 - "[Treatment of brucellosis with streptomycin; preliminary data]."
08/15/2014 - "These selected highly immunogenic protein spots might be useful as alternative antigens for brucellosis and helpful in reducing the cross-reactivity. "
01/01/1991 - "The administration of LBA, whose active principle is a polysaccharide and protein complex, reduced high sensitivity to brucellar antigen and raised the functional activity of neutrophilic granulocytes and T-lymphocytes, improved the late results of the treatment of patients with brucellosis running its course with pronounced sensitization."
01/01/2002 - "This study proposes an improved antigen for the CF test for the epidemiological survey of animal brucellosis. "
01/01/1987 - "An improved antigen is described for use in the serodiagnosis of canine brucellosis. "
01/01/1982 - "[Course of chronic brucellosis in mice is not improved by administration of a vaccinal antigen]."
|6.||Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric
02/01/1986 - "[Treatment of osteoarticular brucellosis with trimethoprim-sulfamethoxazole. "
05/30/1974 - "[Trimethoprim-sulfamethoxazole (TM-SMZ) combination in the treatment of brucellosis]."
11/01/1973 - "Trimethoprim-sulfamethoxazole in brucellosis."
02/01/1972 - "[Therapy of acute human brucellosis with a trimethoprim-sulfamethoxazole combination]."
01/01/1972 - "[Preliminary observations on the treatment of brucellosis with peroral and intravenous administration of a trimethoprim-sulfamethoxazole combination]."
|7.||Anti-Bacterial Agents (Antibiotics)IBA
03/01/2006 - "We retrospectively reviewed 10 patients with spinal brucellosis of the thoracic and lumbar spine who were treated successfully with a combination of surgery and antibiotics. "
01/01/2009 - "Brucella spp. replicate and survive in lympho-proliferative tissues and cells, thus effective treatment of brucellosis requires the combined and long term use of intracellularly active antibiotics. "
01/01/2002 - "[Efficacy of some new antibiotics in treating experimental brucellosis]."
03/01/2013 - "The aim of this study was to evaluate the efficacy of some native plants, alone and in combination with some antibiotics, in the treatment of brucellosis. "
06/01/1956 - " II. Behavior of some immunity indices in brucellosis cured with antibiotics]."
|8.||Gentamicins (Gentamicin)FDA LinkGeneric
09/01/2006 - "The aim of the present work was to study the suitability of polymeric nanoparticles for gentamicin entrapment in view to treat brucellosis. "
06/01/2010 - "He was then diagnosed with brucellosis and started on antimicrobial therapy, including 2 weeks of parenteral gentamicin and two oral agents that were poorly tolerated. "
04/01/2007 - "Drug delivery systems containing gentamicin were studied as a treatment against experimental brucellosis in mice. "
09/01/2006 - "All together, these results indicate that the nanocarriers described in this work may be suitable as gentamicin delivery system to control brucellosis."
05/01/1997 - "Protective effect of liposomal gentamicin against systemic acute murine brucellosis."
10/01/1984 - "Low-molecular glucopeptide stimulated protection against brucellosis without the accumulation of complete antibodies and the increase of skin sensitivity. "
03/01/2013 - "To determine the seroprevalence of brucellosis antibodies in blood donors, a serological study was carried out in central province of Iran. "
07/01/2004 - "In this study, we conclude that brucellosis has peculiar epidemiologic characteristics in blood banks that participated in this research; therefore it is highly recommended to perform screening tests such as BR, SAM, and 2ME to identified anti-Brucella antibodies in the sera of effective blood donors."
02/01/2002 - "For this reason, a validation study was performed in which three indirect enzyme-linked immunosorbent assays (ELISAs), the CFT and the SAT were compared using a panel of sera from brucellosis-free cattle, sera from experimentally infected cattle, and sera from cattle experimentally infected with bacteria which are known to induce cross-reactive antibodies (Pasteurella, Salmonella, Yersinia, and Escherichia). "
09/01/1999 - "Previous studies have shown that the detection of antibodies to an 18-kDa cytoplasmic protein of Brucella spp. is useful for the diagnosis of human and animal brucellosis. "
|10.||Immunoglobulin G (IgG)IBA
11/14/2007 - "Furthermore, escheriosome entrapped rL7/L12 protein elicited high IgG2a isotype response suggestive of its relevance in imparting protection against brucellosis in mice. "
10/01/2011 - "High titer of IgG antibody among the two study groups indicated that most seropositive subjects were in chronic phase of brucellosis."
06/01/2009 - "The prediction is that iELISA based on broadly cross-reacting anti-dolphin IgG antibody would be a reliable test for the diagnosis of brucellosis in odontocetes, including families not covered in this study."
03/01/2013 - " best cut-off point of ELISA-IgG was 10.78 IU/ml which produced the maximal sensitivity and specificity for the diagnosis of human brucellosis. "
03/01/2012 - "The best cut-off point of ELISA-IgG is 53 IU/ml, which yields the maximal sensitivity and specificity to diagnose acute brucellosis."
01/01/2012 - "The results from this study support the use of the Balb/c aerosol nose-only brucellosis mouse model for the evaluation of therapeutics against inhalational brucellosis."
01/01/2012 - "Thus, the results from this study support the use of the RM as an animal model for inhalational brucellosis to evaluate the efficacy of novel vaccines and therapeutics against B. "
06/01/2015 - "The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics."
|2.||Induced Abortion (Induced Abortions)
01/01/2009 - "This study was undertaken to investigate the seroprevalence of brucellosis in unvaccinated sheep from the flocks having previous abortion cases in Kars and around, Turkey and to compare the efficacy of each serological test used. "
06/15/2015 - "This study highlighted an increased prevalence gradient of BTB and brucellosis from West to East along the study sites with high brucellosis individual prevalence and abortion rates among Afar settlements in particular. "
01/01/2005 - "In the present study, we investigated abortion induced by Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in a mouse model. "
11/01/2013 - "Larger flock size and history of previous abortion in the flock were major risk factors identified for sero-positivity of small-ruminant brucellosis. "
01/01/1979 - "When the importance of a herd increase sanitation of tuberculosis in infected herds is less readily achieved and brucellosis abortion rate increases. "
|3.||Drug Therapy (Chemotherapy)
10/01/2004 - "Early diagnosis is important and prompt antibrucellar chemotherapy is effective in most cases, but prolonged follow up is necessary in all patients with spinal brucellosis."
01/01/1957 - "[Clinical & therapeutic studies of 250 cases of brucellosis on the basis of the present-day status of chemotherapy]."
03/26/1953 - "[Enzymatic studies on the change of form of Brucella abortus as contribution to chemotherapy of brucellosis]."
08/01/2014 - "Comparison of two durations of triple-drug therapy in patients with uncomplicated brucellosis: A randomized controlled trial."
02/01/2008 - "Forty years after active drug therapy was defined, there is no optimum antibiotic therapy for brucellosis due to relatively high rates of relapse and treatment failure. "
05/01/2007 - "canis using hot saline, coated on to latex beads and their usefulness in the serological diagnosis of canine brucellosis was examined. "
06/01/2004 - "The intracellular antibiotic efficiency of gentamicin-loaded microspheres in the context of Brucella-infected murine monocytes was examined in vitro with a view to developing improved therapies for the treatment of brucellosis. "
05/01/2007 - "Although these results suggest that our method in which crude hot saline extracted antigens are coated on to latex beads would be useful in the serological diagnosis of canine brucellosis, we need further investigation using more serum samples to confirm the usefulness of our method."
09/01/2006 - "Altogether, these results suggest that 502H and 75:25H microspheres are suitable carriers for gentamicin targeting inside human macrophages and thus for brucellosis treatment."
01/01/1976 - "The different forms of chronic brucellosis have been improved and well stabilized in the proportion of 75% by repeated injections of a vaccine consisting of suspensions of heat-killed B. "
06/01/1957 - "[Treatment of brucellosis by intracutaneous vaccine injections and by vaccine combined with antibiotics]."
03/01/2012 - "Consequently, surgery was postponed and treatment was changed from injections of ceftriaxone to the WHO regimen for the treatment of brucellosis: 1 g streptomycin once daily, administered intra-muscularly, plus 100 mg doxycycline twice daily, taken orally. "