|2.||Respiratory Sounds (Crackle)
|4.||Cystic Fibrosis (Mucoviscidosis)
|1.||Camargo, Carlos A: 17 articles (10/2015 - 06/2007)|
|2.||Mansbach, Jonathan M: 16 articles (10/2015 - 04/2008)|
|3.||Piedra, Pedro A: 15 articles (10/2015 - 04/2007)|
|4.||Korppi, Matti: 14 articles (03/2015 - 04/2008)|
|5.||Klassen, Terry P: 12 articles (01/2015 - 10/2003)|
|6.||Wilkes, David S: 12 articles (08/2014 - 11/2007)|
|7.||Sullivan, Ashley F: 11 articles (10/2015 - 04/2009)|
|8.||Verleden, Geert M: 11 articles (09/2015 - 11/2003)|
|9.||Bont, Louis: 11 articles (01/2014 - 05/2002)|
|10.||Vanaudenaerde, Bart M: 10 articles (09/2015 - 11/2003)|
|1.||Albuterol (Salbutamol)FDA LinkGeneric
06/01/1998 - "Salbutamol was shown to be effective and safe in the treatment of acute bronchiolitis."
06/01/1994 - "Albuterol is as effective as oral placebo in the management of bronchiolitis. "
01/01/1995 - "Salbutamol is safe and effective in relieving the respiratory distress of young infants with acute bronchiolitis. "
05/01/1991 - "We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis."
10/01/1990 - "We conclude that nebulized albuterol constitutes a safe and effective treatment of infants with bronchiolitis."
|2.||Epinephrine (Adrenaline)FDA LinkGeneric
05/01/2010 - "No significant improvement in bronchiolitis seen with hypertonic saline plus epinephrine."
07/01/2000 - "Lung function (tPTEF/tE) was reduced in infants with acute bronchiolitis and improved significantly after inhaled racemic adrenaline. "
07/01/2000 - "The ratio of time to reach peak tidal expiratory flow to total expiratory time (tPTEF/tE) was significantly reduced in children with acute bronchiolitis (mean, 95% CI) (0.08, 0.05-0.10) compared to controls (0.31, 0.18-0.43), with significant improvement after inhaled racemic adrenaline 0.19 (0.13-0.25), parallel with significant clinical improvement. "
02/01/1997 - "Nebulized epinephrine results in significant improvement in clinical scores and airway resistance in children hospitalized with bronchiolitis and in the emergency department causes acute improvement in oxygenation, decreases length of time in the emergency department and admission rate to hospital. "
01/01/2015 - "There is no evidence that the epinephrine-3% hypertonic saline combination is more effective than 3% hypertonic saline alone for treating infants hospitalized with acute bronchiolitis. "
04/01/2013 - "To analyse the safety and efficacy of high-flow oxygen therapy for treatment of moderate to severe bronchiolitis in children admitted to the paediatric hospital wards. "
09/12/2015 - "Management of infants with bronchiolitis to an oxygen saturation target of 90% or higher is as safe and clinically effective as one of 94% or higher. "
07/01/2012 - "Results show that chest physiotherapy has not been effective in reducing hospital stay or length of oxygentherapy in patients with acute bronchiolitis, but in the positive study of children with respiratory syncytial virus in nasopharyngeal aspirate showed a reduced need hours of oxygen. "
12/01/2000 - "No effective treatment of RSV positive bronchiolitis beside supportive care in the form of adequate nutrition and oxygen therapy is available. "
09/01/2015 - "Future work could focus on the safety and effectiveness of using intermittent oxygen saturation monitoring in secondary care, and to consider what are safe and effective oxygen saturation targets for children with bronchiolitis managed in primary care. "
|4.||Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/2015 - "The majority (60.5%) reported that if corticosteroids were beneficial in bronchiolitis, they prefered treatment with a single dose in the ED as opposed to a multiday course. "
04/01/2000 - "Combined, published reports of the effect of systemic corticosteroids on the course of bronchiolitis suggest a statistically significant improvement in clinical symptoms, LOS, and DOS."
07/01/1997 - "Corticosteroids might therefore be effective in the treatment of RSV bronchiolitis. "
05/01/2007 - "Controversy over the efficacy of systemic corticosteroids for acute bronchiolitis initiated this study. "
09/01/1999 - "These in vitro findings showing that dex failed to consistently inhibit all the RSV-induced release of neutrophil inflammatory mediators may explain the variable efficacy of corticosteroids in the treatment of RSV bronchiolitis."
|5.||Bronchodilator Agents (Bronchodilators)IBA
11/01/2003 - "Evidence-based emergency medicine/systematic review abstract: Are bronchodilators effective in bronchiolitis?"
03/01/2009 - "Despite the common clinical practice, the available evidence on the efficacy of bronchodilators therapy for bronchiolitis is conflicting. "
08/01/1997 - "To determine the efficacy of bronchodilators in the treatment of bronchiolitis. "
08/01/1997 - "Much controversy revolves around the efficacy of bronchodilators in the treatment of bronchiolitis. "
08/01/1997 - "Efficacy of bronchodilators in the treatment of bronchiolitis."
|6.||Dexamethasone (Maxidex)FDA LinkGeneric
09/01/2008 - "This study compared efficacy of multiple administrations and a single dose of dexamethasone in bronchiolitis. "
05/01/2007 - "We conducted a randomized, double-blind, placebo-controlled trial to examine the efficacy of single dexamethasone injection for the treatment of acute bronchiolitis in young hospitalized children. "
05/01/2007 - "Efficacy of dexamethasone injection for acute bronchiolitis in hospitalized children: a randomized, double-blind, placebo-controlled trial."
03/01/2009 - "The objective was to compare the efficacy of a single dose of oral dexamethasone in infants with moderate to severe bronchiolitis presenting to an emergency department. "
11/01/2002 - "Oral dexamethasone improved respiratory distress in children < 2 years of age with acute bronchiolitis."
|7.||Ipratropium (Ipratropium Bromide)FDA LinkGeneric
10/01/1997 - "Efficacy of ipratropium bromide by metered dose aerosol and aerochamber in acute paediatric bronchiolitis."
01/01/1995 - "As ipratropium bromide appears to be a more effective bronchodilator drug than beta 2-stimulants in the first year of life, a study was set up to investigate its possible role in bronchiolitis. "
11/01/1983 - "In a double blind randomised trial, we found no evidence that nebulised ipratropium bromide was of clinical benefit in acute bronchiolitis."
11/01/1999 - "Nebulised ipratropium bromide and bronchiolitis."
01/29/1996 - "Ipratropium bromide can be safely used in the management of acute bronchiolitis, recognizing that most infants do not appear to respond to any bronchodilator medication. "
|8.||Ribavirin (Virazole)FDA LinkGeneric
10/01/1996 - "The availability of ribavirin has improved the outlook in high-risk patients who develop respiratory syncytial virus bronchiolitis while intensive efforts are continued to develop an efficacious and safe vaccine. "
07/01/1987 - "Efficacy of ribavirin aerosol treatment for respiratory syncytial virus bronchiolitis in infants."
09/01/1999 - "This trial demonstrates the lack of effectiveness of aerosolized ribavirin in reducing the length of ventilation and course of illness in infants with no underlying illness ventilated for respiratory distress secondary to RSV bronchiolitis."
09/01/1999 - "We undertook a prospective, double-blind, placebo-controlled trial to resolve the question of the clinical effectiveness of ribavirin in previously well infants who require ventilation for respiratory distress secondary to respiratory syncytial virus (RSV) bronchiolitis. "
05/01/1999 - "Prospective follow-up and pulmonary functions from a placebo-controlled randomized trial of ribavirin therapy in respiratory syncytial virus bronchiolitis. "
01/01/2009 - "Performing several multiple Poisson models that also considered Palivizumab use as covariate, although the point estimates were in agreement with previous clinical trial results, we did not find in most of them a significant reduction for immunized children to be hospitalized for bronchiolitis. "
10/01/2003 - "[Potential impact and cost-efficacy of bronchiolitis prophylaxis with palivizumab in preterm infants with a gestational age of less than 33 weeks]."
12/01/2004 - "This study strongly supports the efficacy of prevention of RSV bronchiolitis by palivizumab in severely premature infants with BPD."
05/01/2015 - "A literature search up to December 2012 on the morbidity of RSV bronchiolitis in CF patients and on the safety and efficacy of palivizumab in those patients was performed. "
01/01/2009 - "We evaluated the incidence and risk factors of hospitalization for broncholitis in preterm infants (i.e., a gestational age of <36 weeks) born between 2000 and 2006, and the use and impact of Palivizumab, a monoclonal antibody that in randomized clinical trials has been shown to lessen the severity of RSV-related bronchiolitis. "
|10.||Erythromycin (Erycette)FDA LinkGeneric
07/01/1992 - "These results suggest an important role for the neutrophil in the pathogenesis or development of bronchiolitis, and also suggest that erythromycin may be useful for the treatment of bronchiolitis through its direct action upon host phagocytic cells."
01/01/2000 - "[Efficacy of erythromycin (EM) on a rabbit model of Pseudomonas aeruginosa-induced chronic bronchiolitis--its action on apoptosis]."
01/01/2008 - "Erythromycin therapy resulted in improvement of the follicular bronchiolitis but not the tracheobronchopathia osteochondroplastica."
04/01/1993 - "Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients."
07/01/1992 - "Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients."
11/01/1993 - "In spite of these caveats, surviving children often have good functional results and a markedly improved quality of life after heart-lung and lung transplantation unless or until severe chronic rejection and obliterative bronchiolitis occur.(ABSTRACT TRUNCATED AT 250 WORDS)"
01/01/2011 - "Ingraft chimerism in lung transplantation--a study in a porcine model of obliterative bronchiolitis."
07/01/2005 - "For clinical lung transplantation the results of our study suggest that protection of the integrity of airway epithelium may be important in preventing the development of obliterative bronchiolitis."
01/27/2002 - "Previous studies have implicated the allogeneic immune response in the development of obliterative bronchiolitis after lung transplantation. "
01/01/2015 - "Obliterative bronchiolitis (OB) ranks as the major obstacle for long-term survival of lung transplantation patients. "
|2.||Transplantation (Transplant Recipients)
10/01/2004 - "Smad3 deficiency ameliorates experimental obliterative bronchiolitis in a heterotopic tracheal transplantation model."
06/01/2013 - "Orthotopic tracheal transplantation in mice can be considered as a model to study early stages of obliterative bronchiolitis, and heterotopic tracheal transplantation can be a model for late stages of obliterative bronchiolitis."
06/01/2013 - "In this study, we compared three prevalent murine models of obliterative bronchiolitis in terms of several basic pathologic changes in a relatively short span of time after transplantation. "
11/01/2010 - "For this ethics committee-approved study, supine and prone multidetector-row CT (4×1 mm collimation, 0.5 s rotation time, 140 kVp, and effective 80 mAs) was performed at full end-expiration on 47 lung transplant recipients (mean age 41±12 y; 18 without bronchiolitis, 18 with potential bronchiolitis, and 11 with bronchiolitis). "
06/01/2008 - "The present study demonstrates that dendritic cells from nonobliterative bronchiolitis lung transplant recipients induce a tolerant T-cell phenotype which is dependent on cytotoxic T-lymphocyte antigen-4 engagement."
|3.||Continuous Positive Airway Pressure
01/01/2011 - "Nasal continuous positive airway pressure may be beneficial in children with severe bronchiolitis but a large trial is needed to determine its value. "
04/01/2009 - "Question 3. Is continuous positive airway pressure effective in bronchiolitis?"
10/01/2008 - "To determine the efficacy of nasal continuous positive airway pressure (nCPAP) on respiratory distress symptoms and respiratory effort in young infants with acute respiratory syncytial virus bronchiolitis. "
04/01/2015 - "The study included children<2 years old hospitalized with bronchiolitis who required admission to the ICU and/or continuous positive airway pressure (CPAP) within 24 hours of admission. "
04/01/2015 - "Continuous positive airway pressure with helmet versus mask in infants with bronchiolitis: an RCT."
01/01/2015 - "Early high flow nasal cannula therapy in bronchiolitis, a prospective randomised control trial (protocol): A Paediatric Acute Respiratory Intervention Study (PARIS)."
11/01/2012 - "The objective of this study was to identify any laboratory and clinical variables that may predict high-flow nasal cannula failure in management of bronchiolitis in the pediatric intensive care unit. "
12/01/2015 - "To assess the association of the introduction of a high-flow nasal cannula (HFNC) protocol with clinical outcomes and hospital charges of infants with bronchiolitis initially admitted to the PICU. "
12/01/2015 - "Effect of a Hospital-wide High-Flow Nasal Cannula Protocol on Clinical Outcomes and Resource Utilization of Bronchiolitis Patients Admitted to the PICU."
09/01/2015 - "High-Flow Nasal Cannula and Aerosolized β Agonists for Rescue Therapy in Children With Bronchiolitis: A Case Series."
12/01/1996 - "Improved management strategies are necessary to prevent the development of progressive graft dysfunction after retransplantation for obliterative bronchiolitis."
04/15/2015 - "In the current study, we identified a novel effect of IL-26 on transplant-related obliterative bronchiolitis. "
03/01/2015 - "In this study, we induced obliterative bronchiolitis and studied the contribution of regulatory T cells to its development in immune-deficient mice receiving heterotopic porcine bronchus transplants, and major histocompatibility complex-mismatched porcine peripheral blood mononuclear cell. "
01/01/2007 - "Although certain limitations exist, the pursuit of proof-of-concept studies in this model, as well as other animal models, can provide the basis for genetic and cellular translational human studies directed toward post-transplant obliterative bronchiolitis pathogenesis. "
07/01/2015 - "Lung transplant survival is limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. "