|1.||Cystic Fibrosis (Mucoviscidosis)
|3.||Asthma (Bronchial Asthma)
|5.||Lung Diseases (Lung Disease)
|1.||Chang, Anne B: 15 articles (06/2015 - 01/2009)|
|2.||Müller, Nestor L: 14 articles (09/2014 - 06/2002)|
|3.||Hansell, David M: 13 articles (01/2016 - 08/2003)|
|4.||Johkoh, Takeshi: 13 articles (02/2014 - 06/2002)|
|5.||Bilton, Diana: 11 articles (12/2015 - 11/2006)|
|6.||Hill, Adam T: 11 articles (02/2015 - 02/2011)|
|7.||Greenstone, M: 11 articles (01/2007 - 01/2001)|
|8.||Wells, Athol U: 10 articles (01/2016 - 08/2003)|
|9.||Chalmers, James D: 10 articles (10/2015 - 02/2011)|
|10.||De Soyza, Anthony: 10 articles (09/2015 - 12/2012)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
12/01/2015 - "Forced expiratory volume in 1 s improved after physiotherapy, as did alveolar volume after intravenous antibiotics, but LCI did not change significantly.LCI is reproducible in stable bronchiectasis but unlike conventional lung function tests, is unresponsive to two short-term interventions and hence is unlikely to be a useful clinical tool for short-term acute assessment in these patients. "
01/01/2013 - "Eight-weekly intravenous antibiotics is beneficial in severe bronchiectasis."
05/01/2015 - "Food and Drug Administration (FDA)-approved antibiotics for the treatment of patients with bronchiectasis, this review will highlight the current state of the science with regard to antibiotics that may be effective in non-CF bronchiectasis as well as highlighting those in development to treat this complex disease."
01/01/2013 - "Treatment with 8-weekly intravenous antibiotics in severe bronchiectasis reduced exacerbation frequency and improved exercise tolerance and health-related quality of life."
01/01/2011 - "There is insufficient evidence in the current literature to make reasonable conclusions about the efficacy of short course antibiotics in the management of adults and children with bronchiectasis. "
|2.||Mannitol (Osmitrol)FDA LinkGeneric
01/01/2006 - "Inhalation of mannitol (400 mg) twice daily over 2 weeks improved the quality of life significantly in patients with bronchiectasis. "
08/01/2012 - "The few published papers on this topic concluded that mannitol, when inhaled as a dry powder, is a promising treatment for bronchiectasis. "
01/01/2011 - "Dry powder mannitol has the potential to be used to enhance clearance of mucus in subjects with bronchiectasis. "
06/01/1999 - "In conclusion, inhalation of dry powder mannitol increased clearance of mucus and thus has the potential to benefit patients with bronchiectasis."
03/01/2010 - "The aim of the study was to investigate: 1) the effect of increasing doses of mannitol and repetitive coughing on the sputum physical properties; 2) if the changes in sputum properties can predict the efficacy of mucus clearance measured by radioaerosol technique in bronchiectasis patients. "
04/01/2010 - "They have been proven to be beneficial in diffuse panbronchiolitis and are commonly being used in patients with bronchiectasis. "
03/01/1995 - "Purified guinea pig eosinophils were cultured in the presence or absence of sputum extracts, and the eosinophil viability was measured on Day 4. Eosinophil viability in the presence of sputum extracts derived from patients during moderate or severe attacks was significantly higher than that for sputum obtained from patients in remission or during mild attacks or from those with other respiratory diseases, including bronchiectasis and diffuse panbronchiolitis (p < 0.05). "
08/01/1995 - "To study the role of T cells in diffuse panbronchiolitis (DPB), we investigated T-cell subsets in bronchoalveolar lavage fluid (BALF) or 33 patients with DPB, nine patients with bronchiectasis, and 20 healthy volunteers. "
01/01/2015 - "We retrospectively investigated the prevalence of NTM associated with diffuse panbronchiolitis (DPB), a disorder also characterized by reduced mucociliary clearance with bronchiectasis. "
09/01/1997 - "In conclusion, EM therapy for diffuse panbronchiolitis may be stopped if the clinical manifestations of disease (especially purulent sputum) disappear, if diffuse, nodular opacities resolve almost completely and if there is no evidence of bronchiectasis."
10/01/2014 - "Existing studies on the use of low-dose macrolides in non-CF bronchiectasis are encouraging, but further studies are needed to define the optimal agent, dose, duration for treatment, and the patients likely to benefit and long-term safety. "
10/01/2014 - "However, these studies suggested that macrolides can reduce exacerbation frequency, reduce sputum volume, and improve lung function in patients with non-CF bronchiectasis. "
07/01/2014 - "The purpose of this paper is to review the efficacy and potential risks of these recent studies on the use of macrolides in non-CF bronchiectasis. "
02/02/2011 - "Until larger studies with long-term follow up are available, the use of macrolides in bronchiectasis should be restricted to selected cases and should take into account their potential side effects."
01/01/2011 - "Seven clinical studies that evaluated the action of the macrolides in patients with bronchiectasis were found. "
|5.||Ciprofloxacin (Cipro)FDA LinkGeneric
03/01/1996 - "The findings suggest that ciprofloxacin is an effective treatment of infective exacerbations of bronchiectasis."
09/01/2013 - "Phase II, 24-week Australian/New Zealand multicentre, randomised, double-blind, placebo-controlled trial in 42 adult bronchiectasis subjects with ≥2 pulmonary exacerbations in the prior 12 months and ciprofloxacin-sensitive P aeruginosa at screening. "
05/01/2013 - "Analysis and discussion of the results of a Phase II study evaluating the efficacy and safety of the inhaled ciprofloxacin-dry powder (C-DPI) formulation in patients with non-CF bronchiectasis. "
09/01/2013 - "Once-daily inhaled DRCFI demonstrated potent antipseudomonal microbiological efficacy in adults with non-CF bronchiectasis and ciprofloxacin-sensitive P aeruginosa. "
04/01/2003 - "Five Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. "
|6.||Tobramycin (Nebcin)FDA LinkGeneric
11/01/2006 - "The addition of an inhaled tobramycin solution to therapy with oral Cip for the treatment of acute exacerbations of bronchiectasis due to P aeruginosa improved microbiological outcome and was concordant with clinical outcome; the inability to demonstrate an additional clinical benefit may have been due to emergent wheeze resulting from treatment."
04/01/2005 - "A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis."
09/01/2001 - "A randomized, placebo-controlled, multicenter trial evaluated the safety and efficacy of 300 mg aerosolized tobramycin solution for inhalation (TSI) administered twice daily for 4 weeks in 74 bronchiectasis patients colonized with Pseudomonas aeruginosa (PA). "
08/01/2000 - "We conducted a placebo-controlled, double-blind, randomized study to evaluate the microbiological efficacy and safety of inhaled tobramycin for treatment of patients with bronchiectasis and Pseudomonas aeruginosa. "
01/01/2015 - "In this review we will present and discuss the published evidence regarding the use of inhaled tobramycin in non-CF bronchiectasis. "
|7.||Azithromycin (Zithromax)FDA LinkGeneric
11/01/2014 - "We evaluated the efficacy of a 12-week oral treatment with azithromycin in adult patients with bronchiectasis. "
11/01/2014 - "Efficacy of azithromycin in the treatment of bronchiectasis."
01/01/2005 - "We investigated whether the addition of 6-months' twice-weekly azithromycin to the existing treatment regimen in patients with pulmonary bronchiectasis decreased the number of exacerbations and improved pulmonary function compared with a similar period of time without concurrent azithromycin. "
01/01/2012 - "This study tests the hypothesis that azithromycin administered once a week as maintenance antibiotic treatment will reduce the rate of pulmonary exacerbations in Indigenous children with bronchiectasis. "
01/01/2012 - "Azithromycin for Indigenous children with bronchiectasis: study protocol for a multi-centre randomized controlled trial."
|8.||Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/2009 - "To evaluate the efficacy of inhaled corticosteroids (ICS) in children and adults with bronchiectasis (a) during stable bronchiectasis; and for reducing; (b) the severity and frequency of acute respiratory exacerbations and (c) long term pulmonary decline. "
06/01/1998 - "The temporal relationship of the bronchiectasis and coeliac disease, and the subsequent stabilisation of her clinical symptoms and improvement in pulmonary physiology following treatment with inhaled corticosteroids, suggests a relationship between the two conditions which may be due to immunological mechanisms."
10/01/2008 - "The present study identified three patients with bronchiectasis receiving inhaled corticosteroids (ICSs) who had symptomatic adrenal suppression secondary to ICS. "
01/01/2002 - "To determine the concentration of exhaled H(2)O(2) in patients with bronchiectasis, and to study the relationship between levels of exhaled H(2)O(2), extent of disease, symptoms score, spirometry, and cellular composition obtained from induced sputum; furthermore, to account for possible confounding effects of inhaled corticosteroids (ICS) usage, long-term oral antibiotic treatment, and chronic colonization with Pseudomonas aeruginosa. "
01/01/2014 - "To assess the effects of inhaled long-acting beta2-agonists (LABA) combined with inhaled corticosteroids (ICS) in children and adults with bronchiectasis during (1) acute exacerbations and (2) stable state. "
|9.||Amoxicillin (Wymox)FDA LinkGeneric
02/01/1983 - "Three grams of amoxycillin administered twice daily for seven days, as an oral powder (Amoxil 3G sachets, Bencard) dispersed in water, to 17 patients with bronchiectasis resulted in striking clinical, spirometric and bacteriological improvement in 11 of 12 patients who were producing purulent sputum from which Haemophilus influenzae was cultured by a selective bacteriological technique (Roberts & Cole, 1980). "
03/01/1990 - "Amoxycillin 3 g twice daily is effective in treating patients with bronchiectasis who have daily purulent sputum. "
08/01/1990 - "Double-blind randomized study of prolonged higher-dose oral amoxycillin in purulent bronchiectasis."
07/01/1992 - "Eight patients with bronchiectasis received 500 mg of amoxicillin three times daily. "
08/01/1990 - "Thirty-eight patients with bronchiectasis and daily expectoration of purulent sputum despite conventional antibiotic courses were randomly allocated to receive a sachet of amoxycillin (3 g) or matched placebo twice daily for 32 weeks in a double-blind study. "
|10.||Erythromycin (Erycette)FDA LinkGeneric
02/01/1999 - "Further studies are indicated to evaluate the efficacy of long-term erythromycin therapy in bronchiectasis."
03/27/2013 - "Twelve-month, randomized (1:1), double-blind, placebo-controlled trial of erythromycin in currently nonsmoking, adult patients with non-CF bronchiectasis with a history of 2 or more infective exacerbations in the preceding year. "
06/01/2011 - "In an attempt to power a definitive randomised-controlled trial (RCT), an uncontrolled evaluation of the impact of long-term, low-dose oral erythromycin therapy upon pulmonary exacerbation frequency in non-CF bronchiectasis subjects was performed. "
02/01/1999 - "A double-blind placebo-controlled study was therefore conducted to evaluate the effects of 8-week administration of low dose erythromycin (500 mg b.i.d.) in steady-state idiopathic bronchiectasis. "
12/01/2014 - "Long-term erythromycin treatment changes the composition of respiratory microbiota in patients with bronchiectasis. "
01/01/2004 - "The purpose of this study was to compare the efficacy of the test of incremental respiratory endurance (TIRE) with active cycle of breathing techniques (ACBT) [incorporating postural drainage (PD) and vibration] as methods of airway clearance in adults with bronchiectasis. "
10/01/1947 - "Dynamic postural drainage: an improved method in the treatment of bronchiectasis."
05/01/2015 - "Previous studies have evaluated the effectiveness of postural drainage (PD), percussion (PERC), the coughing technique (CT), and other types of coughing in subjects with bronchiectasis. "
01/01/2004 - "Airway clearance in bronchiectasis: a randomized crossover trial of active cycle of breathing techniques (incorporating postural drainage and vibration) versus test of incremental respiratory endurance."
01/01/2007 - "Flutter, active cycle of breathing technique (ACBT) and ACBT with postural drainage (ACBT-PD) were evaluated in random order over a week in 36 patients (mean age 62 years, range 33-83), with stable non-CF bronchiectasis. "
11/01/2012 - "Furthermore, the scores for extent of bronchiectasis (2.7 ± 1.6), the scores for the bronchial wall thickening of bronchiectasis (1.3 ± 0.4) and the global CT score (6.7 ± 2.5) in the treatment group were significantly improved as compared with those [(4.8 ± 2.0), (1.8 ± 0.5), (9.7 ± 3.6)] in the control group respectively after treatment. "
11/01/2012 - "The scores for the extent of bronchiectasis (2.7 ± 1.6), the bronchial wall thickening of bronchiectasis (1.3 ± 0.4) and the global CT score (6.7 ± 2.5) were reduced after treatment as compared to those before treatment [(4.8 ± 2.3), (1.8 ± 0.5), (9.5 ± 3.3)] in the treatment group, (all P < 0.01). "
11/01/2009 - "Among 12 patients with bronchiectasis, there were 4 men and 8 women with the mean age of 47.58 (SD=18.32) yr. The mean increase in the ratios of VC, FVC and FEV₁ to predicted values and also patients FEV₁/FVC after treatment were 15.50% (SD=14.40), 49.83% (SD=8.19) 8.17% (SD=12.07) and 7.17% (SD=12.68), respectively. "
09/01/1994 - "All have some localized bronchiectasis on CT scanning, in two cases probably occurring after treatment started, but in no case is there any respiratory disability. "
04/01/2003 - "Traction bronchiectasis was seen in 12 patients, and it improved in four patients after treatment. "
|3.||Gamma Cameras (Gamma Camera)
05/15/1982 - "Fifteen consecutive patients with bronchiectasis were examined for ciliary defects by examining the nasal mucosae with an electron microscope and measuring the clearance of technetium-99m from the lung with a gamma camera. "
01/01/2006 - "Clinical studies using radioaerosols, and imaging with a gamma camera, have demonstrated that hypertonic saline (HS; 3-14.4%) and mannitol (300-400 mg) increase clearance of mucus acutely in patients with mild asthma, bronchiectasis, and cystic fibrosis (CF). "
12/01/2015 - "The United Network for Organ Sharing database was queried from 1987 to 2013 to compare survival in adult patients with non-CF bronchiectasis to patients with CF listed for lung transplantation (LTx). "
04/01/2015 - "We report a series of 6 XLA patients with bronchiectasis who underwent lung transplantation. "
04/01/2015 - "Despite the association with end-stage bronchiectasis, the literature on XLA and lung transplantation is extremely limited. "
12/01/2013 - "A 42-year-old woman underwent bilateral lung transplantation for severe bronchiectasis. "
06/01/2012 - "The purpose of this article is to update specialists in pulmonary medicine on the role of surgical resection and lung transplantation for bronchiectasis. "
|5.||Drug Therapy (Chemotherapy)
10/01/1977 - "Five children in remission from acute lymphoblastic leukaemia developed bronchiectasis when on chemotherapy. "
02/01/2015 - "Developing drug therapies in bronchiectasis."
03/01/2014 - "Bronchiectasis: an update on current pharmacotherapy and future perspectives."
12/01/2007 - "Pharmacotherapy for bronchiectasis."
03/01/1996 - "The respiratory tracts of bronchiectasis patients may be persistently colonized with Pseudomonas aeruginosa, despite intensive chemotherapy. "