Bromodeoxyuridine (BrdU)

A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

Also Known As:

Networked: 3535 relevant articles (62 outcomes, 355 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ono, Koji: 40 articles (12/2019 - 03/2002)
2.	Suzuki, Minoru: 36 articles (12/2019 - 01/2003)
3.	Masunaga, Shin-Ichiro: 27 articles (12/2019 - 03/2002)
4.	Sakurai, Yoshinori: 21 articles (12/2019 - 12/2002)
5.	Kinashi, Yuko: 21 articles (10/2010 - 12/2002)
6.	Liu, Yong: 17 articles (01/2021 - 10/2005)
7.	Maruhashi, Akira: 17 articles (12/2019 - 09/2004)
8.	Tanaka, Hiroki: 17 articles (12/2019 - 01/2008)
9.	Chopp, Michael: 16 articles (01/2022 - 01/2002)
10.	Wei, Ling: 16 articles (10/2021 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2008 - "These results suggest that BrdU may have an important role as an adjunctive therapeutic for a wide variety of cancers based on new insights into its effect as a negative regulator of cell cycle progression." 08/06/2021 - "In conclusion, cancer studies mostly utilize MTT or BrdU assays in estimating cell proliferation and calculating IC50 of drugs, which provided conflicting VPA dosages utilizing PANC-1 cells. " 01/01/2013 - "In the first study, small animal Positron Emission Tomography (PET) imaging studies were conducted with [(18)F]ISO-1 and (18)FDG in xenografts of mouse mammary tumor 66 and tracer uptake was correlated with the in vivo P:Q ratio determined by flow cytometric measures of BrdU-labeled tumor cells. " 01/01/2012 - "In tumor-bearing mice, we found that Helios(+) Treg were relatively over-represented in the tumor-mass, and BrdU studies showed that, in vivo, Helios(+) Treg proliferated more than Helios(-) Treg. " 11/01/2008 - "Immunohistochemistry was performed to identify BrdU-positive cells to study tumor cell proliferation. "
2.	Infarction (Infarctions) 02/01/2023 - "After co-staining with BrdU and doublecortin (DCX), a marker for NPCs, the migration of Brdu and DCX double positive NPCs was detected along the rostral migratory stream (RMS) and around the infarct area using frozen brain sections. " 01/01/2021 - "In conjunction with any sign of calcification, a higher number of BrdU-labelled cells, and a low level of CD68 positive cells were observed in the infarct region under electromechanically stimulated conditions compared with static conditions. " 01/01/2021 - "Additionally, PGRN increased the percentage of BrdU+/Doublecortin (DCX)+ cells in the ipsilateral SVZ 14 d after pMCAO and increased the percentage of new neurons (BrdU+/NeuN+ cells) in the peri-infarct striatum 28 d after pMCAO, suggesting that PGRN promotes neuronal differentiation. " 01/01/2020 - "Lower-intensity treadmill exercise increased the number of BrdU/NeuN colabeled cells, but not total BrdU-retaining or BrdU/Sox2-colabeled cells, in the peri-infarct region of the ipsilateral cortex. " 01/01/2017 - "BrdU labelled positive cells with green fluorescence were observed in the brain tissue of groups C and D, which mainly distributed in the striatum, cerebral cortex, and subcortex around the infarction area. "
3.	Inflammation (Inflammations) 05/01/2008 - "This study investigated the frequency of BrdU or SPION uptake by AM using the Boyden chamber model of inflammation. " 01/01/2023 - "Mice fed MD showed significantly lower percent of BrdU-incorporated hepatocytes and a higher trend of inflammation compared to the mice fed LD. " 01/01/2022 - "Using this flow cytometry framework in parallel with histology and BrdU tracing, we characterize intestinal eosinophil subphenotypes and monitor their plasticity at baseline and within the context of acute allergic and chronic systemic inflammation. " 07/12/2019 - "Lung tissues, bronchoalveolar lavage flow (BALF) and bone marrow tissues of these mice were collected in order to evaluate airway inflammation and amount of newly produced (Brdu positive) and mature Eos. " 10/01/2016 - "From the jejunum to the rectum, late-stage inflammation with glandular regeneration, as well as a high-level BrdU labeling index, was present. "
4.	Stroke (Strokes) 06/01/2009 - "In addition, postischemic survival of endogenous doublecortin (Dcx)-positive NPC was improved within the lesioned striatum of TAT-Hsp70-treated animals for up to 4 weeks after stroke without changing overall cell proliferation of BrdU(+) cells. " 10/01/2015 - "n-3 PUFAs also robustly improved revascularization and angiogenesis and boosted the survival of NeuN/BrdU labeled newborn neurons up to 35days after stroke injury. " 12/01/2018 - "In immunohistochemical staining, significant increases in NeuN/BrdU and Glut-1/BrdU double positive cells were seen in stroke mice received HP-BMSCs compared to those received regular BMSCs. " 08/01/2018 - "Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days 4, 5, and 6, immunohistochemistry was performed on week 2 or 4, MRI on day 7, and lipidomic analysis at 4 and 5 h after onset of stroke. " 01/01/2018 - "Conclusion: BrdU administered prior to, and after stroke, allows to investigate brain vasculature remodeling in the adult brain."
5.	Seizures (Absence Seizure) 06/09/2023 - "Moreover, the density of BrdU+NeuN+ cells was increased in an aberrant location, the hilus, of CORT+FLX mice, similar to previous studies describing aberrant neurogenesis following seizures. " 02/01/2008 - "In the present study, quantitative analysis of BrdU labeling revealed a significant increase in the proliferation rate of neuronal progenitor cells after KA-induced seizures in the KD-fed mice. " 02/15/2004 - "Rats were injected with bromodeoxyuridine to label proliferating cells in the dentate gyrus after single/multiple electroconvulsive seizures in a dose-response study and at various time points after single electroconvulsive seizures in a time-course study. " 11/01/2014 - "Here, we have addressed this issue by analyzing immunohistochemically: (1) the brain levels of total and phosphorylated mTOR in young (before seizures) and adult WAG/Rij rats; (2) the proliferation of hippocampal neuronal stem/progenitor cells assessed by BrdU analysis at different ages. " 06/01/2013 - "We labeled seizure-generated cells with the proliferation marker BrdU after 30-stimulations and continued kindling for an additional 4weeks to allow newborn neurons to mature under conditions of repeated seizures. "

Related Drugs and Biologics

1.	Bromodeoxyuridine (BrdU)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Proteins (Proteins, Gene)
4.	Thymidine
5.	Nestin
6.	Caveolin 1
7.	DNA (Deoxyribonucleic Acid)
8.	Cytokines
9.	Brain-Derived Neurotrophic Factor (BDNF)
10.	Quercetin

Related Therapies and Procedures

1.	Transplantation
2.	Radiotherapy
3.	Therapeutics
4.	Injections
5.	Intra-Arterial Infusions