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Brinolase

A fibrinolytic and thrombolytic enzyme from Aspergillus oryzae. EC 3.4.99.-.

Also Known As:

Brinase

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Brinolase: 12

Related Diseases

1.	Ischemia 09/01/1979 - "Clinical trial of brinase and anticoagulants as a method of treatment for advanced limb ischemia." 09/01/1979 - "A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. "
2.	Arterial Occlusive Diseases (Arterial Occlusive Disease) 11/15/1975 - "Brinase was administered intra-arterially in 16 patients with thrombotic or embolic arterial occlusions. " 07/01/1975 - "One patient with acute arterial occlusion of the right leg with obstruction of blood flow from the external iliac artery showed complete disobliteration after a series of i.v. brinase infusions. " 12/14/1974 - "[Thrombolytic treatment of arterial occlusions with brinase, a proteolytic enzyme produced by aspergillus]."
3.	Hemorrhage 07/01/1975 - "Bleeding complications due to brinase treatment were not observed." 07/01/1975 - "Bleeding complications associated with brinase treatment were not observed in the material. "
4.	Ascites 12/01/1975 - "Thein vitro effects of the proteolytic enzyme brinase on ascites tumour cells were studied histochemically. " 12/01/1975 - "Histochemical effects of the proteolytic enzyme brinase on ascites tumour cells." 05/15/1971 - "The effects of protease I of Aspergillus oryzae (brinase) on membrane permeability and growth of Landschütz ascites tumour cells."
5.	Thrombosis (Thrombus) 01/01/1988 - "The proteinase, brinase (Mr approximately 35000), from Aspergillus oryzae, which has been used in therapeutic attempts as a thrombolytic agent in arterial thrombosis, binds to purified human alpha 2-macroglobulin (alpha 2M) with a stoichiometry of 1.7-1.9 mol of enzyme/mol inhibitor. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
3.	Streptokinase
4.	Fibrinolytic Agents (Antithrombotic Agents)
5.	Enzymes
6.	Catechin (Z 7300)
7.	Anticoagulants
8.	Ancrod (Arvin)
9.	troxerutin

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Sympathectomy (Sympathectomies)
3.	Surgical Amputation (Amputations)
4.	Immunotherapy