Brenner Tumor

A smooth, solid or cystic fibroepithelial (FIBROEPITHELIAL NEOPLASMS) tumor, usually found in the OVARIES but can also be found in the adnexal region and the KIDNEYS. It consists of a fibrous stroma with nests of epithelial cells that sometimes resemble the transitional cells lining the urinary bladder. Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported.

Also Known As:

Networked: 58 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Endometrial Hyperplasia
3.	Papillomavirus Infections
4.	Polyps
5.	Neoplasms (Cancer)

Experts

1.	Costeira, Filipa de Sousa: 1 article (02/2022)
2.	Cunha, Teresa Margarida: 1 article (02/2022)
3.	Félix, Ana: 1 article (02/2022)
4.	Chen, Yuntao: 1 article (01/2022)
5.	Huang, Chen: 1 article (01/2022)
6.	Li, Jiong: 1 article (01/2022)
7.	Qin, Guoyou: 1 article (01/2022)
8.	Wang, Ce: 1 article (01/2022)
9.	Wu, Zhenyu: 1 article (01/2022)
10.	Xu, Huilin: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brenner Tumor:

1.	Estrogens (Estrogen)FDA Link 01/01/2002 - "A case of estrogen-producing Brenner tumor with a stromal component as a potential source for estrogen." 02/01/2022 - "Their imaging features are very similar, the differentiation is based on secondary characteristics, such as signs or symptoms of estrogen excess and the presence of a second ovarian neoplasm, which has been reported in up to 30% of patients with Brenner tumor. " 01/01/2002 - "Considering the known source of estrogen production being tumor cells in certain cases of Brenner tumor, there seem to be two types of estrogen-producing Brenner tumors depending on the source of estrogen, i.e. " 01/01/2020 - "Various studies have shown an association of Brenner tumor with endometrial hyperplasia, polyp, or early-stage carcinoma, probably due to its estrogen-secreting nature. " 07/01/2006 - "Although there are several reports of Brenner tumor showing estrogen activities, it is an extremely rare cause of androgen excess leading to virilism, and the source or mechanism of its androgen production is also unknown at present. "
2.	DNA (Deoxyribonucleic Acid)IBA 07/01/2007 - "The molecular study, by polymerase chain reaction (PCR) failing to reveal the presence of HPV DNA, demonstrates that neither the TCCE nor the ovarian Brenner tumor is caused by an HPV infection. "
3.	Testosterone (Sustanon)FDA Link 08/15/1963 - "TESTOSTERONE SYNTHESIS BY A BRENNER TUMOR. " 08/15/1963 - "TESTOSTERONE SYNTHESIS BY A BRENNER TUMOR. " 01/01/2011 - "A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a Brenner tumor." 01/01/2011 - "The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. " 10/01/2016 - "Testosterone Aromatization to Estradiol in Course of Ovarian Functioning Brenner Tumor Associated With Endometrial Carcinoma and Endometriosis (Roncati-Manenti Triad)."
4.	Proteins (Proteins, Gene)FDA Link 02/01/2015 - "All Brenner tumors were diffusely positive for GATA3 and negative for Paired box gene 8, PAX2, and Sal-like protein 4. Interestingly, the areas of mucinous epithelium as well as mucinous tumors, intermixed and adjacent to the Brenner tumor, were negative for all 4 markers; however, occasional basal-like cells retained expression of GATA3. " 03/01/2009 - "To further investigate the similarities (or dissimilarities) between female genital tract transitional proliferations and bladder urothelium, we evaluated the expression of S100P and GATA3, 2 proteins that we previously found to be strongly expressed in bladder urothelial tumors, in 25 benign ovarian Brenner tumors, 19 Walthard cell nests (17 tubal and 2 ovarian hilus), 1 mature teratoma with a benign urothelial proliferation, 2 proliferating (borderline) ovarian Brenner tumors, 1 malignant Brenner tumor, and 12 ovarian transitional cell carcinomas (TCC). " 10/01/2016 - "The immunohistochemical investigation proved a normal expression of the DNA mismatch repair proteins and revealed a bimodal hormonal status in the pathological tissues, that is, the Brenner tumor cells showed a high expression of testosterone, contrariwise endometrioid carcinoma and endometriosis a high estrogen and progesterone immunolabeling. "
5.	ProgesteroneFDA LinkGeneric 01/01/2007 - "A case of bilateral Brenner tumor with endometrial adenocarcinoma in a postmenopausal woman is presented and the features are briefly discussed, with the conclusion that hormone-producing Brenner tumors may exert their promoter effect on the development of endometrial carcinoma causing an imbalance in the oestrogen and progesterone ratio rather than producing a large amount of oestrogen." 02/01/1987 - "Estrogen synthesizing rare malignant Brenner tumor of the ovary with the presence of progesterone and androgen receptors in the absence of estrogen receptors." 10/01/2016 - "The immunohistochemical investigation proved a normal expression of the DNA mismatch repair proteins and revealed a bimodal hormonal status in the pathological tissues, that is, the Brenner tumor cells showed a high expression of testosterone, contrariwise endometrioid carcinoma and endometriosis a high estrogen and progesterone immunolabeling. "
6.	EnzymesIBA 11/01/1989 - "Brenner tumor of the ovary: immunoanalysis of steroidogenic enzymes in 23 cases." 01/01/2011 - "The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. " 12/01/1989 - "This review provides the localization of sex-steroid hormone biosynthesis in normal and pathological human ovaries including sex-cord stromal tumors, hyperthecosis and Brenner tumor, as determined by the tissue distribution of immunoreactivity of individual enzymes specific for different stages of the biosynthetic process."
7.	ElementsIBA 01/01/2013 - "Our cases highlight that an absence of a borderline element should not dissuade the pathologist from diagnosing a malignant Brenner tumor." 06/01/2012 - "Seventeen cases (56%) were pure Brenner tumors, measuring from 0.5 to 2.5 cm and 13 cases (44%) were mixed tumors consisting of a Brenner tumor element and a mucinous ovarian tumor (10/13 cases, 53.8%) and a germ cell tumor in 3/13 cases. " 01/01/2012 - "The findings suggests that there were cases of ovarian cyst composed only of Brenner tumor and struma ovarii, that such a case may be monodermal mature cystic teratoma or the Brenner tumor element was derived from surface epithelium in the preexisting struma ovarii, and that such a tumor manifest as cystic torsion." 06/01/2012 - "The largest diameter of the mixed tumors ranged from 7 to 22 cm. The largest area consisting of Brenner elements measured 7 cm. The immunoprofile of Brenner tumor cell was cytokeratine-7 positive (30/30 cases) cytokeratine-20 negative in the Brenner cell element but positive in the mucinous component in 5/7 cases of mixed Brenner tumors, focally WT-1 positive (5/30 cases), NSE negative (0/30 cases) and focally chromogranine positive (6/30 cases), Uroplakin-III positive in 23/30 cases, with faint cytoplasmatic or luminal distribution. " 01/01/2012 - "Immunohistochemically, the Brenner tumor element was positive for cytokeratins (AE1/3 and CAM5.2) and Ki67 (labeling=3%), but negative for thyroglobulin, TTF-1, p53, CA125, and vimentin. "
8.	Uroplakin IIIIBA 06/01/2012 - "The largest diameter of the mixed tumors ranged from 7 to 22 cm. The largest area consisting of Brenner elements measured 7 cm. The immunoprofile of Brenner tumor cell was cytokeratine-7 positive (30/30 cases) cytokeratine-20 negative in the Brenner cell element but positive in the mucinous component in 5/7 cases of mixed Brenner tumors, focally WT-1 positive (5/30 cases), NSE negative (0/30 cases) and focally chromogranine positive (6/30 cases), Uroplakin-III positive in 23/30 cases, with faint cytoplasmatic or luminal distribution. " 08/01/2009 - "Immunohistochemical staining of malignant Brenner tumor often demonstrates positivity for uroplakin III, thrombomodulin and cytokeratin 7 and negativity to cytokeratin 20. "
9.	UroplakinsIBA 02/01/2001 - "Brenner tumor cells also expressed uroplakins Ia and II. CA125 was observed focally in some Brenner tumors. " 10/01/1999 - "Focal expression of uroplakins was observed on the luminal surface of ovarian Brenner tumor cells forming microcysts in all 5 cases examined. "
10.	Keratin-20 (Cytokeratin 20)IBA 07/01/2015 - "Immunostains for cytokeratin 7 showed diffuse positivity in the epithelial nests, whereas cytokeratin 20 and inhibin were negative, further supporting the diagnosis of a Brenner tumor. " 08/01/2009 - "Immunohistochemical staining of malignant Brenner tumor often demonstrates positivity for uroplakin III, thrombomodulin and cytokeratin 7 and negativity to cytokeratin 20. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/2015 - "Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: An analysis of 10 cases within a single center." 01/01/2014 - "[Malignant Brenner tumor with very good response after chemotherapy: about a case and review of the literature]." 12/01/1988 - "Three cases of stage III malignant Brenner tumor of the ovary in which chemotherapy or radiotherapy favorably altered the clinical courses are reported, and the literature is reviewed."
2.	Hysterectomy 06/01/1999 - "We present a case of a woman in which we found a Brenner Tumor in the left ovary while we were performing an abdominal total hysterectomy. " 01/01/1980 - "We present the fourth case report of an extraovarian Brenner tumor, which was an incidental finding in a total hysterectomy 53-year-old woman. " 09/01/2012 - "She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and final pathology revealed malignant Brenner tumor in association with a mature cystic teratoma. "
3.	Therapeutics 02/13/2023 - "In this case report, we present our case along with a review of the current literature regarding the diagnosis and therapy of malignant Brenner tumor. " 07/01/2001 - "A 44-year-old woman with a history of bilateral breast carcinoma presented with leiomyomatosis peritonealis disseminata and a right ovarian Brenner tumor 18 months after beginning adjuvant tamoxifen therapy. "
4.	Radiotherapy 12/01/1988 - "Three cases of stage III malignant Brenner tumor of the ovary in which chemotherapy or radiotherapy favorably altered the clinical courses are reported, and the literature is reviewed." 01/01/2022 - "The multivariable competing risk analysis suggested that older age at initial cancer diagnosis, white race, epithelial histologic subtypes of OC (serous, endometrioid, mucinous, and Brenner tumor), number of lymph nodes examined (<12), and radiotherapy were significantly associated with an elevated SPM risk. "
5.	Laparotomy 01/01/1992 - "The authors report two cases of malignant ovarian Brenner tumor treated by polychemotherapy, that had a complete histological response confirmed by a second look laparotomy. " 04/01/2023 - "The patient underwent exploratory laparotomy with removal of the ovarian cyst, later diagnosed as a focal MBT in a background of borderline Brenner tumor. "