|1.||Basal Cell Carcinoma (Rodent Ulcer)
|3.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
|1.||Yu, Hsin-Su: 10 articles (02/2015 - 10/2002)|
|2.||Morton, C A: 9 articles (05/2013 - 10/2000)|
|3.||Lee, Chih-Hung: 8 articles (02/2015 - 09/2004)|
|4.||Liao, Wei-Ting: 8 articles (05/2012 - 10/2002)|
|5.||Chen, Gwo-Shing: 6 articles (02/2015 - 10/2002)|
|6.||Szeimies, Rolf-Markus: 6 articles (06/2010 - 01/2005)|
|7.||Morton, Colin A: 6 articles (01/2007 - 04/2002)|
|8.||Kawana, Seiji: 5 articles (08/2014 - 09/2003)|
|9.||Hong, Chien-Hui: 4 articles (02/2015 - 05/2011)|
|10.||Nakajima, Susumu: 4 articles (08/2014 - 10/2004)|
11/01/2004 - "Our findings showed that PDT is highly effective in treating Bowen's disease and SCC lesions and can be used as a first treatment modality in so far as its use does not preclude the subsequent surgery recommended for the small percentage of failures."
03/01/2001 - "In an open study, 35 (88%) of 40 large patches of Bowen disease, all with a maximum diameter greater than 20 mm, cleared following 1 to 3 treatments of delta-ALA PDT, although 4 patches recurred within 12 months. "
06/01/1997 - "ALA PDT is a simple, effective and well tolerated treatment for large patches of Bowen's disease."
03/01/2001 - "In 10 further patients with multiple (> or =3) patches of Bowen disease, 44 (98%) of 45 patches cleared following delta-ALA PDT, although 4 lesions recurred over 12 months. "
10/01/2005 - "This study has shown that the PDL is an effective light source for ALA-PDT of Bowen's disease. "
|2.||imiquimod (Aldara)FDA LinkGeneric
04/01/2007 - "Topical 5% imiquimod cream appears to be clinically beneficial in the treatment of Bowen's disease and should be considered as a treatment option."
02/01/2012 - "Imiquimod cream, effective in treating Bowen's disease in healthy women, may be a useful postsurgical treatment in immunocompromised women. "
03/01/2001 - "Imiquimod 5% cream appears to be an effective treatment for Bowen's disease on the lower limbs. "
01/01/2005 - "Imiquimod 5% cream: a new treatment for Bowen's disease."
03/01/2001 - "This was a phase II, open-label study in 16 patients, treating a single biopsy-proven plaque of Bowen's disease that was 1 cm or larger in diameter, with once-daily self-application of imiquimod 5% cream for 16 weeks. "
|3.||Fluorouracil (Carac)FDA LinkGeneric
06/01/1976 - "An ususual case of Bowen's disease of the skin of the penile shaft treated successfully with topical 5-fluorouracil is presented along with a review of different modes of treatment."
03/01/2003 - "The results presented in this article confirm that treatment of Bowen's disease with topical 5-Fluorouracil cream is safe and effective treatment."
03/01/2005 - "Topical 5-fluorouracil in the management of extensive anal Bowen's disease: a preferred approach."
03/01/2004 - "Topical 5-fluorouracil (5-FU) is a standard treatment for Bowen's disease. "
03/01/2003 - "Twenty-four patients with 26 biopsy-confirmed lesions of Bowen's disease were treated with topical 5-Fluorouracil cream and were followed for periods of up to 10 years. "
06/01/1997 - "The arsenic-induced decrease in RI was significantly greater in arsenic-induced Bowen's disease patients than in matched controls. "
10/01/2002 - "Previous studies revealed that patients with arsenic-induced Bowen's disease showed a defective cell-mediated immunity and decreased percentages of T cell and T helper cell subpopulations in peripheral mononuclear cells. "
09/01/2011 - "This article also reviews the causative and differential role of selective CD4 cell apoptosis and the carcinogenesis of arsenic-induced Bowen's disease."
07/01/2011 - "Multiple Bowen's disease in a patient with a history of possible arsenic exposure: a case report."
06/01/2009 - "Patients with arsenic-induced Bowen's disease (As-BD) showed both cutaneous and systemic immune dysfunctions. "
|5.||Aminolevulinic Acid (Levulan)FDA Link
11/01/2005 - "Subungual Bowen's disease treated by topical aminolevulinic acid-photodynamic therapy."
08/01/2002 - "Eighty-eight patients, including 34 cases of basal cell carcinoma (BCC), 32 cases of squamous cell carcinoma (SCC), two cases of basal-squamous cell carcinoma (BSCC), one case of verrucuous carcinoma, nine cases of Bowen disease, two cases Paget disease of the nipple and eight cases of extramammary Paget disease, were treated by the partial differential alpha-aminolevulinic acid induced photodynamic therapy first in China from 1997 to 2000. "
08/01/2013 - "Results from numerous studies with aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) for the treatment of AKs, SCC, and Bowen's disease show high rates of clearance for these lesions. "
04/01/2011 - "Two photosensitizers have been used mainly for photodynamic therapy of Bowen's disease therapy: δ-aminolevulinic acid and methyl aminolevulinate. "
07/01/2010 - "We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). "
08/01/2001 - "The keratin expression in Bowen's disease has been studied in many reports. "
12/01/1991 - "Our results revealed clear differences in keratin expression between the clinically normal skin of patients with solitary Bowen's disease and that of patients with chronic arsenicalism. "
12/01/1991 - "This work seeks to clarify the differences between multiple Bowen's disease in the blackfoot disease endemic area, and solitary Bowen's disease in a non-endemic area by means of Ks 8.12 monoclonal cytokeratin antibody staining. "
11/01/1991 - "In addition, the most proliferative of in situ malignancies (Bowen's disease) also contained small numbers of cells expressing simple epithelial keratins. "
01/01/1988 - "No differences between Bowen's disease and bowenoid papulosis were found in terms of densities of S 100-positive dendritic cells and keratin pattern. "
06/01/1989 - "In Bowen's disease, a heterogeneous staining pattern with varying intensity among individual cells was seen with all of the antibodies used. "
04/01/1986 - "Based on a study of 11 cases of Bowen's disease, eight cases of Paget's disease, and nine cases of malignant melanoma in situ, we conclude that the atypical clear cells of Bowen's disease stain only with antibodies to KER; those of Paget's disease, exclusively with antibodies to CEA; and those of malignant melanoma in situ, with antibodies to S-100. "
12/01/1987 - "The results indicate that antibodies to cytokeratins of different molecular weights may be used as a diagnostic tool in the distinction of Paget's disease from Bowen's disease and melanoma."
03/01/1993 - "These findings are helpful for differentiating Paget's disease from other lesions of the nipple, namely Bowen's disease and eczema which do not react with both antibodies, and from nipple adenoma which exhibits a positive staining with anti-EMA antibody and no reactivity with anti-c-erbB-2 antibody."
04/01/1995 - "The dyskeratotic cells in Bowen's disease showed a reduction or loss of staining with these antibodies, and they were occasionally positive for keratin 19. "
10/01/1987 - "[An immunohistochemical study of a papillomavirus antigen in bowenoid papulosis and Bowen's disease]."
12/01/2000 - "CD1a+, CD3+, CD4+, CD8+, CD68+ and cutaneous lymphocyte-associated antigen-positive cells in Bowen's disease."
01/01/1990 - "We studied 173 biopsies of histologically determined Bowen's disease and looked for the presence of papillomavirus antigen using immunoperoxidase staining. "
01/01/1990 - "Papillomavirus common antigen in Bowen's disease."
01/01/1987 - "They were found in 7 out of 8 biopsies from Bowen's disease and bowenoid papulosis, which were viral antigen negative. "
02/01/1996 - "Similar to the E-cadherin expression in normal epidermis, E-cadherin was strongly expressed in all samples of BCC on the cell borders, whereas marked decrease or loss of E-cadherin expression was found in the tumor cells of SCC, Paget's disease, and Bowen's disease (invasive type). "
05/01/2000 - "From the results of our study, we suggest that Bowen's disease and basal cell carcinoma do not have much metastatic potential due to retention of high levels of E-cadherin expression. "
09/01/2011 - "To elucidate the immune evasion mechanisms of HPV, we have examined the density, dynamics, and subsets of dendritic cell (DC) types in non-inflammatory or inflammatory HPV-related skin lesions such as warts and Bowen's disease (HPV-Bowen), and compared the epidermal expression levels of macrophage inflammatory protein (MIP)-3α and E-cadherin. "
08/01/2006 - "To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC). "
02/01/2002 - "Thus, abnormal expression of the E-cadherin/catenin complex was quite common in SCC and Bowen's disease and also in a proportion of intraepithelial dysplastic lesions, such as atypical squamoproliferative lesions and actinic keratosis, suggesting that these changes may be early indicators of the neoplastic process. "
02/01/2002 - "Treatment of arsenical keratosis and Bowen's disease with acitretin."
03/01/2005 - "Another trial involving 44 subjects treated with acitretin 30 mg daily or placebo for 6 months reported two of 19 subjects developing two SCCs in the treatment group vs. nine of 19 subjects developing 18 new skin cancers (15 SCCs, one Bowen's disease, two basal cell carcinomas) in the placebo group. "
09/01/2003 - "Thereafter, interferon was stopped whereas acitretin therapy was continued, but a new Bowen's disease developed in the perianal region, and the acitretin dose was increased at 0.5 mg/kg per day. "
02/01/2002 - "Although these results need to be confirmed by larger, long-term trials, it appears that acitretin is effective in the treatment of Bowen's disease related with arsenic, as well as arsenical keratosis."
|1.||Photochemotherapy (Photodynamic Therapy)
02/01/2005 - "A new treatment for Bowen's disease is photodynamic therapy. "
07/01/2010 - "Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease."
07/01/2012 - "Effectiveness of photodynamic therapy in Bowen's disease: an observational and descriptive study in 51 lesions."
04/01/2011 - "The purpose of this paper is to summarize the results of clinical and research studies with respect to the photodynamic therapy of Bowen's disease. "
12/01/1992 - "The purpose of this study was to illustrate the effectiveness of photodynamic therapy in the treatment of Bowen's disease. "
|2.||Cryotherapy (Therapy, Cold)
07/01/1995 - "Serial overlapping cryotherapy fields of up to 2 cm diameter were shown to be a valid treatment option for Bowen's disease, as no patients had therapy-related failure to heal. "
07/01/1995 - "The results of wound healing in these patients were compared with the results of cryotherapy to 82 lower leg Bowen's disease lesions in 49 dermatology patients. "
05/01/1983 - "Cryotherapy for multicentric pigmented Bowen's disease."
10/01/2000 - "Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a prospective study."
11/01/1996 - "Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease."
12/01/2000 - "Carbon dioxide laser provides ease of surgery, excellent cosmesis, preservation of function, and effective treatment for patients with Bowen's disease of the digits."
12/01/2000 - "This study was undertaken to evaluate the effectiveness of carbon dioxide laser for Bowen's disease of the digit. "
09/01/2013 - "Successful treatment of periungual pigmented Bowen disease with CO2 laser."
01/01/2008 - "To report our experience with CO2 laser vaporization in the treatment of Bowen's disease and try to identify which factors could have any influence on results. "
01/01/2008 - "Bowen's disease treated by carbon dioxide laser. "
12/01/2013 - "Multiple-digit periungual Bowen's disease: a novel treatment approach with radiotherapy."
05/01/1955 - "[A case of cutaneous Bowen's disease cured by radiotherapy]."
01/01/2009 - "Treatment-resistant giant unilateral Bowen's disease of the scalp responding to radiotherapy."
09/01/2008 - "Radiotherapy using a water bath in the treatment of Bowen's disease of the digit."
09/01/2001 - "A retrospective outcomes review of radiotherapy for Bowen's disease was performed to analyze all patients treated with radiation therapy between 1993 and 1997 at the Naval Medical Center, San Diego. "
10/01/2005 - "Investigation of the use of the pulsed dye laser in the treatment of Bowen's disease using 5-aminolaevulinic acid phototherapy."
12/01/2012 - "Dye laser photodynamic therapy for Bowen's disease in a patient with epidermodysplasia verruciformis."
01/01/2012 - "Light-emitting diode laser versus pulsed dye laser-assisted photodynamic therapy in the treatment of actinic keratosis and Bowen's disease."
06/01/2012 - "Comparison of the efficacy of ALA-PDT using an excimer-dye laser (630 nm) and a metal-halide lamp (600 to 740 nm) for treatment of Bowen's disease."
10/01/2005 - "The aim of this study was to assess the efficacy and safety of the pulsed dye laser (PDL) as the light source for photoactivation of the protoporphyrin IX to treat Bowen's disease by PDT. "