Bongkrekic Acid

An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.

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Networked: 37 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Hong, Jiann-Ruey: 3 articles (02/2016 - 04/2006)
2.	Wu, Jen-Leih: 3 articles (02/2016 - 04/2006)
3.	Huang, Qiong: 2 articles (11/2019 - 10/2019)
4.	Long, Chaoyang: 2 articles (11/2019 - 10/2019)
5.	Zhang, Yonghui: 2 articles (11/2019 - 10/2019)
6.	Aramaki, Hironori: 2 articles (01/2017 - 10/2016)
7.	Matsumoto, Kenji: 2 articles (01/2017 - 10/2016)
8.	Okazaki, Hiroyuki: 2 articles (01/2017 - 10/2016)
9.	Shindo, Mitsuru: 2 articles (01/2017 - 10/2016)
10.	Takeda, Shuso: 2 articles (01/2017 - 10/2016)

Related Diseases

1.	Poisoning 01/01/2023 - "The prohibition of traditional processed homemade fermented corn flour products and improvement in bongkrekic acid poisoning case identification and early treatment have resulted in a reduction in the case-fatality rate." 09/01/2023 - "Bongkrekic acid (BA) poisoning can progress rapidly and lead to the failure of multiple organs, such as brain, liver and kidney. " 01/01/2023 - "Epidemiology of foodborne bongkrekic acid poisoning outbreaks in China, 2010 to 2020." 12/18/2020 - " Poisoning incidents caused by bongkrekic acid (BA), one of the metabolites of Burkholderia gladioli pathovar cocovenenans (B. " 12/18/2020 - "A Foodborne Bongkrekic Acid Poisoning Incident - Heilongjiang Province, 2020."
2.	Ischemia 05/01/2012 - "Given the opposed roles of the MPTP in cardioprotection (transient versus sustained opening) the primary aim of this study was to determine how two structurally different MPTP inhibitors (cyclosporine A and bongkrekic acid) administered for varying time regimes influenced ischemia/reperfusion (I/R)-induced injury in myocardial slices from rat left ventricle. " 11/09/2001 - "In contrast, inhibitors of the mitochondrial permeability transition (MPT), cyclosporin A and bongkrekic acid, did not alter [Ca(2+)](m) accumulation during ischemia, but markedly suppressed the surge in rhod-2 fluorescence during reperfusion. " 04/01/2001 - "Bongkrekic acid also offered significant neuroprotection against ischemia-induced caspase-3 and caspase-9 activation and cell death in the brain. "
3.	Foodborne Diseases 01/01/2023 - "Bongkrekic acid (BA) is a mitochondrial toxin that causes high mortality but is often mistakenly categorized as other food poisonings. " 01/01/2003 - "Burkholderia cocovenenans produces a lethal toxin (Bongkrekic acid) that leads to high fatality in food poisoning cases. " 05/20/1991 - "Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. " 03/01/1989 - "The existence of bongkrekic acid in toxic fermented corn samples collected during food poisoning outbreaks was also confirmed. " 10/26/2023 - "Bongkrekic acid (BKA) poisoning, induced by the contamination of Burkholderia gladioli pathovar cocovenenans, has a long-standing history of causing severe outbreaks of foodborne illness. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 06/01/2003 - "These changes were not observed in cortical astrocytes at corresponding concentrations of DNB and were prevented in brainstem astrocytes by the mtPTP inhibitor, bongkrekic acid, suggesting that mitochondrial dysfunction is involved in DNB-induced morphological changes in brainstem astrocytes. " 08/09/2002 - "Bongkrekic acid (50 micromol/L), an inhibitor of the PT pore, prevented BNIP3-induced mitochondrial defects and cell death. " 07/01/2010 - "As bongkrekic acid also prevents zinc-triggered neuronal death but not ERK1/2 phosphorylation, activation of MAPK signaling precedes and is required for mitochondrial dysfunction and cell death. " 01/15/2016 - "Albeit carboxyatractyloside (CATR) and bongkrekic acid (BKA) are known to be powerful and highly selective AAC inhibitors, able to induce mitochondrial dysfunction at molecular level and poisoning at physiological level, we estimated here for the first time their affinity for the human recombinant AAC2 by in vitro transport assays. " 08/01/2008 - "Both mitochondrial dysfunction and necrosis were sensitive to the compounds cyclosporin A and bongkrekic acid, as well as the calcineurin inhibitor FK506. "
5.	Necrosis 03/01/2003 - "However, bongkrekic acid, another mPTP blocker, also increased necrosis in HUAEC. " 02/02/2016 - "Phosphatidylserine (PS) exposure and loss of ΔΨm from apoptosis/necrosis was attenuated by treatment with the adenine nucleotide translocase inhibitor bongkrekic acid (BKA) and the protein synthesis inhibitor cyclohexamide (CHX). " 08/01/2008 - "Both mitochondrial dysfunction and necrosis were sensitive to the compounds cyclosporin A and bongkrekic acid, as well as the calcineurin inhibitor FK506. " 04/10/2006 - "Annexin V staining revealed that the NNV infection of GL-av cells induced phosphatidylserine (PS) externalization and development of bulb-like vesicles (bleb formation) at 24 h p.i. NNV infection also induced DNA fragmentation detectable by TUNEL assay between 12 h (8%) and 72 h (32%) p.i. Bongkrekic acid (1.6 microM; BKA) blocked permeability of the mitochondrial permeability transition pore, but cyclosporine A (CsA) did not block secondary necrosis. " 12/01/2006 - "Inhibitors of the mitochondrial permeability transition pore, cyclosporin A and bongkrekic acid, and inhibitors of respiratory complex III, stigmatellin and antimycin A, but not inhibitor of complex I, rotenone, partly prevented necrosis evoked by exposure of the cells to Cd(2+). "

Related Drugs and Biologics

1.	Cyclosporine (Ciclosporin)
2.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3.	ATP Translocases Mitochondrial ADP
4.	Mitochondrial Permeability Transition Pore
5.	Caspase 9
6.	Caspase 3 (Caspase-3)
7.	Phosphatidylserines
8.	carboxyatractyloside
9.	Calcineurin Inhibitors
10.	Caspase Inhibitors