Bone Neoplasms (Bone Cancer)

Tumors or cancer located in bone tissue or specific BONES.
Also Known As:
Bone Cancer; Neoplasms, Bone; Cancer of the Bone; Bone Neoplasm; Neoplasm, Bone; Cancer of Bone
Networked: 506 relevant articles (23 outcomes, 87 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Neoplasms (Cancer)
3. Chordoma
4. Sarcoma (Soft Tissue Sarcoma)
5. Residual Neoplasm


1. Mantyh, Patrick W: 18 articles (12/2014 - 10/2002)
2. Ghilardi, Joseph R: 11 articles (08/2012 - 09/2004)
3. Sevcik, Molly A: 9 articles (03/2009 - 09/2004)
4. Menéndez, Luis: 8 articles (01/2014 - 05/2003)
5. Hidalgo, Agustín: 8 articles (01/2014 - 05/2003)
6. Baamonde, Ana: 8 articles (01/2014 - 05/2003)
7. Mantyh, P W: 8 articles (12/2010 - 05/2000)
8. Liu, Yue: 7 articles (10/2015 - 08/2011)
9. Gu, Xiaoping: 7 articles (10/2015 - 01/2010)
10. Hou, Wei: 7 articles (09/2015 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bone Neoplasms:
1. Morphine (MS Contin)FDA LinkGeneric
2. Acetaminophen (Paracetamol)FDA LinkGeneric
3. Nerve Growth Factor (NGF)IBA
4. Oxycodone (Oxycontin)FDA LinkGeneric
5. OsteoprotegerinIBA
6. Small Interfering RNA (siRNA)IBA
7. Carbon MonoxideIBA
8. Fentanyl (Sublimaze)FDA LinkGeneric
9. Adenosine Monophosphate (AMP)IBA
10. KetorolacIBA

Therapies and Procedures

1. Spinal Injections
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Oral Administration
06/01/2014 - "Cebranopadol exhibits highly potent and efficacious antinociceptive and antihypersensitive effects in several rat models of acute and chronic pain (tail-flick, rheumatoid arthritis, bone cancer, spinal nerve ligation, diabetic neuropathy) with ED50 values of 0.5-5.6 µg/kg after intravenous and 25.1 µg/kg after oral administration. "
01/01/2010 - "In the present report, we use a mouse model of bone cancer pain and examine whether oral administration of a selective small molecule Trk inhibitor (ARRY-470, which blocks TrkA, TrkB and TrkC kinase activity at low nm concentrations) has a significant effect on cancer-induced pain behaviors, tumor-induced remodeling of sensory nerve fibers, tumor growth and tumor-induced bone remodeling. "
01/01/2005 - "These data suggest that bone cancer pain is effectively treated by oral administration of indomethacin, acetaminophen, and morphine and that the co-administration of acetaminophen and an opioid provides a beneficial effect when treating of bone cancer pain."
01/01/2005 - "Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain. "
01/01/2005 - "To test the analgesic effects of nonsteroidal antiinflammatory drugs on bone cancer pain, the authors examined the effects of oral administration of a cyclooxygenase-1 (COX-1) selective inhibitor (SC560), a COX-2 selective inhibitor (celecoxib), and a nonselective COX inhibitor (indomethacin) on bone cancer pain and compared these effects to the effect of orally administered acetaminophen and morphine. "
5. Combined Modality Therapy