Blood Group Incompatibility

A mismatch between donor and recipient blood. Antibodies present in the recipient's serum are directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Also Known As:
Blood Group Incompatibilities; Group Incompatibilities, Blood; Group Incompatibility, Blood; Incompatibilities, Blood Group; Incompatibility, Blood Group
Networked: 129 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infertility (Sterility)
2. Jaundice
3. Anoxia (Hypoxia)
4. Chronic Kidney Failure (Chronic Renal Failure)
5. Infection


1. Stussi, Georg: 4 articles (03/2007 - 03/2006)
2. Seebach, Jörg D: 4 articles (03/2007 - 03/2006)
3. Schanz, Urs: 4 articles (03/2007 - 03/2006)
4. Mueller, Regula J: 3 articles (03/2007 - 03/2006)
5. Kahwaji, Joseph: 2 articles (07/2015 - 11/2010)
6. Jordan, Stanley C: 2 articles (07/2015 - 11/2010)
7. Kute, Vivek B: 2 articles (10/2014 - 08/2013)
8. Gumber, Manoj R: 2 articles (10/2014 - 08/2013)
9. Vanikar, Aruna V: 2 articles (10/2014 - 08/2013)
10. Trivedi, Hargovind L: 2 articles (10/2014 - 08/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Blood Group Incompatibility:
1. AntibodiesIBA
2. BilirubinIBA
3. Immunoglobulins (Immunoglobulin)IBA
09/01/2010 - "[Meta analysis of the effect of immunoglobulin infusion on neonatal isoimmune hemolytic disease caused by blood group incompatibility]."
06/01/1971 - "Blood group incompatibility and immunoglobulin levels."
09/01/2014 - "Blood group incompatibility in kidney transplants from a living donor can be successfully overcome by using various desensitization protocols: intravenous immunoglobulin, plasmapheresis (PP), immunoadsorption, and double filtration PP. "
01/01/1993 - "Nine cases of newborn patients who developed hyperbilirubinemia due to blood group incompatibility and were treated with high dose (1 gram/Kg) intravenous immunoglobulin (IVIG) are described. "
03/01/1967 - "This paper reviews earlier studies identifying 3 possible immunologic causes of infertility: autoimmunity, ABO blood group incompatibility, and isoagglutination, and presents results of recent studies, including an analysis of the incidence of isoagglutinations, autoagglutinations, and ABO incompatibility in a group of couples with unexplained primary or secondary infertility and couples with an organic cause of infertility; incidence of antibodies in postpartum women, women in early pregnancy, unmarried women, and prostitutes; the relationship between ABO incompatibility and/or sperm-agglutinating antibodies to postcoital testing of cervical mucus; results of condom therapy in couples with positive isoagglutinins; a comparison of hemagglutination test with the microagglutination test; and preliminary studies of the immunoglobulin responsible for a positive microagglutination reaction. "
4. Oxytocin (Pitocin)FDA LinkGeneric
5. Blood Group Antigens (Blood Groups)IBA
6. SodiumIBA
7. Reserpine (Serpasil)FDA Link
8. Promethazine (Promet)FDA LinkGeneric
9. Phenytoin (Dilantin)FDA LinkGeneric
10. Diazepam (Valium)FDA LinkGeneric

Therapies and Procedures

1. Transplants (Transplant)
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Transplantation (Transplant Recipients)
4. Phototherapy (Light Therapy)
02/01/2012 - "Jaundice caused by blood group incompatibility or requiring phototherapy may be associated with a greater increase in type 1 diabetes risk and deserves further study."
01/01/1988 - "[Effectiveness of phototherapy in the treatment of jaundice caused by ABO and Rh blood group incompatibility]."
05/06/2004 - "The presence of ABO blood group incompatibility was a significant variable in relation to unconjugated bilirubin that required phototherapy. "
01/01/2015 - "Additionally, actionable treatment or referral levels for phototherapy and exchange transfusion are proposed within the context of several confounding factors such as widespread exclusive breastfeeding, infections, blood group incompatibilities and G6PD deficiency, which place infants at high risk of severe hyperbilirubinaemia and bilirubin-induced neurologic dysfunction in LMICs, as well as the limited facilities for clinical investigations and inconsistent functionality of available phototherapy devices. "
03/01/1992 - "On the basis of four variables, i.e., peak serum bilirubin level, age of attaining the peak level, age of starting phototherapy and total duration of phototherapy, the cases of hyperbilirubinemia can be categorized into three groups: (a) Group I (mild) included non-hemolytic hyperbilirubinemia, i.e., idiopathic, bacterial infections, intrauterine infections and others, (b) Group II (moderate) comprised of hemolytic as well as non-hemolytic hyperbilirubinemia due to prematurity, administration of oxytocin, bruising/cephalhematoma, and (c) Group III (severe) comprised of hyperbilirubinemia due to hemolysis as a result of blood group incompatibility between the mother and the neonate and G-6-PD deficiency. "
5. Heterologous Transplantation (Xenotransplantation)