|1.||Franchini, Massimo: 19 articles (10/2013 - 04/2004)|
|2.||Mannucci, Pier Mannuccio: 11 articles (01/2015 - 09/2004)|
|3.||Lippi, Giuseppe: 11 articles (10/2013 - 01/2006)|
|4.||Schöchl, Herbert: 10 articles (04/2015 - 01/2010)|
|5.||Mannucci, P M: 10 articles (11/2014 - 01/2000)|
|6.||Levi, Marcel: 9 articles (11/2014 - 08/2003)|
|7.||Peyvandi, F: 9 articles (05/2014 - 12/2001)|
|8.||Levi, M: 9 articles (11/2011 - 03/2000)|
|9.||Spek, C Arnold: 8 articles (08/2015 - 01/2005)|
|10.||Oldenburg, J: 8 articles (06/2015 - 12/2000)|
|1.||Hemophilia A (Haemophilia)
11/01/2014 - "Studies conducted before the advent of safe and effective coagulation factor replacement therapy suggest that the haemophilia population was predominantly of low socioeconomic status with many social disadvantages, including high rates of disability and unemployment and low rates of marriage. "
08/01/2010 - "Canine models have been good predictors of efficacy of hemophilia treatments, including recombinant human coagulation factor (F)VIIa (hFVIIa). "
01/01/2006 - "Plasma-derived concentrates of coagulation factors VIII and IX allow for effective treatment of haemophilia A and B. "
12/28/2002 - "It has been shown that this treatment is effective in patients with haemophilia and an inhibiting antibody against a coagulation factor. "
06/01/2000 - "The availability of new safe coagulation factors has improved the prognosis of haemophilia."
01/01/1998 - "Coagulation factor replacement, appropriate care of the bleeding site and early physical therapy helps to prevent complications and yields the best results. "
10/01/1997 - "The marked decrease in hemorrhage seen in nactin-treated animals may reflect an interaction of Mac-1 with blood coagulation factors. "
08/01/2013 - "The aim of this study was to determine the association between standard laboratory tests, coagulation factor concentrations, and Rotation Thromboelastometry (ROTEM® delta, TEM® International GmbH, Munich, Germany) in patients undergoing major surgery with hemorrhage. "
01/01/2011 - "Ongoing studies will help further define the role of coagulation factor concentrate prophylaxis in patients with bleeding disorders."
01/01/2009 - "Fifteen children with bleeding disorders requiring prophylactic home treatment with coagulation factors were recruited to the study. "
04/11/2012 - "These results suggested pENW attenuated thrombus formation in part by inhibiting platelet activation instead of coagulation factors, presented evidence of pENW interfering intracellular signaling system in the process of platelet activation and indicated the possibility that pENW could potentially be developed as a novel therapeutic agent in the prevention and treatment of thrombotic disorders."
01/01/2012 - "This study confirms the mechanisms of simultaneous activities of intrinsic coagulation factors and impaired fibrinolysis predisposing obese subjects to thrombosis."
09/01/2011 - "Data from experimental models using mice and clinical studies of patients with hereditary deficiencies of coagulation factors XI or XII have shown that both of these clotting factors are important for thrombosis, while having minor or no apparent roles in processes that terminate blood loss (hemostasis). "
03/01/1999 - "Coagulation factor levels predict arterial thrombosis in epidemiological studies, but studies of older persons are needed. "
05/01/1989 - "Thrombosis of vessels at all levels was a prominent feature, suggesting that study of coagulation factors may be important. "
01/01/2000 - "The adoption of these measures has dramatically reduced the risk of transmission of bloodborne infections by plasma-derived coagulation factor concentrates. "
04/12/2012 - "Using novel engineered HSV1 variants deficient in either TF and/or gC, in the present study, we show that activated coagulation factors X (FXa) or VII (FVIIa) directly affect HSV1 infection of human umbilical vein endothelial cells in a manner that is dependent on viral TF and gC. "
01/01/1991 - "This study confirms that replacement therapy with coagulation factors is accompanied by an increased risk for acquiring parvovirus B19 infection. "
01/01/2015 - "In this paper, we presented previously described changes in biochemical and coagulation factors in RHDV infection. "
10/01/2014 - "In the late 1980s, following the human immunodeficiency virus (HIV) epidemic and transfusion-transmitted infections from plasma-derived coagulation factor concentrates to hemophiliacs, many “advanced thinkers” claimed that plasma-derived products would be completely replaced by the year 2000 by safe recombinant products in most developed countries. "
|5.||Acquired Immunodeficiency Syndrome (AIDS)
06/01/1994 - "Those students who thought that "the number of HIV-infected persons will rapidly increase" tended to respond that "they are worried about getting AIDS in the future"; "they will not change their attitudes to their HIV-infected friends"; and "the persons who got AIDS through coagulation factor products should be supported." The results also show that a seminar about HIV/AIDS that provides information in a short period of time is effective in reducing prejudice and improving attitudes toward HIV-infected persons."
06/01/2000 - "From the beginning of the follow-up of AIDS patients in 1987, only 7 (2%) of hemophiliacs have been HIV-infected, all before 1990 and due to non-inactivated coagulation factor concentrates. "
07/01/1999 - "Our group conducted a national survey of patients who had died of acquired immunodeficiency syndrome (AIDS) after being infected with human immunodeficiency virus type 1 (HIV-1) by contaminated blood coagulation factor products. "
01/01/1984 - "Exposure to the AIDS-associated retrovirus (ARV) has been observed in 54 hemophiliacs in Southern Spain who have received commercial coagulation factors manufactured in the United States. "
07/01/2014 - "Nowadays patients receiving blood components are exposed to much less transfusion-transmitted infectious diseases than three decades before when among others HIV was identified as causative agent for the acquired immunodeficiency syndrome and the transmission by blood or coagulation factors became evident. "
|2.||Factor VIII (Coagulation Factor VIII)
|4.||Fibrinogen (Factor I)
|5.||Factor IX (PTC)
|6.||Factor VIIa (Activated Factor VII)
|7.||Factor Xa (Coagulation Factor Xa)
|9.||Vitamin K 1 (Phylloquinone)
|2.||Platelet Transfusion (Blood Platelet Transfusions)
|4.||Blood Transfusion (Blood Transfusions)