Blister (Bulla)

01/01/2013 - "The study provided evidence that 5-FU and MMC biological delivery membranes could significantly improve the outcome of filtering procedures, the survival of the bleb, and maintenance of lower IOP. "
01/01/1998 - "This study confirms the effectiveness and relative safety of delayed post-operative 5-FU treatment in patients with clinical evidence of bleb failure. "
02/08/2021 - "Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision."
01/01/2019 - "In the early post-operative period, there was persisting elevation of IOP, therefore sclera lap was discontinued and 5-fluorouracil was applied under the filter blister. "
01/01/2019 - "Bleb needle revision with and without 5-FU were equally likely to succeed."

04/01/2011 - "To assess the efficacy of needle revision using mitomycin C (MMC) for reviving failed filtering blebs during the late postoperative period and its safety for the corneal endothelium. "
08/01/2009 - "Aberrant wound-healing response in mitomycin C-treated leaking blebs: a histopathologic study."
10/13/2023 - "In a subcohort of deep sclerectomy blebs augmented by intraoperative Mitomycin-C, the trabeculo-Descemet window was significantly longer in the complete success compared to the qualified success group (613.7 vs. 378.1 vs. 450.8 µm in CS vs. QS vs. F, p = 0.004). "
02/18/2023 - "Delayed wound healing, the long-term complication of mitomycin C, can occur several years later and may rarely cause a subsequent inadvertent filtering bleb. "
02/01/2022 - "To analyse the morphological evolution of filtering blebs with anterior-segment OCT (AS-OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3-month follow-up period. "

09/01/1986 - "Treatment with a moderate dose of corticosteroid was effective in controlling the bullous lesions."
01/01/2001 - "The patient had painful erosions in her mouth and flaccid blisters of the skin and was diagnosed as having PV, which responded well to corticosteroid treatment. "
08/15/2023 - "Bullae progression was refractory to corticosteroid treatment and associated with deterioration of respiratory symptoms. "
05/01/2023 - "Most vesicular and bullous lesions were self-limited or treated with topical corticosteroids. "
03/15/2022 - "Upon corticosteroid discontinuation, the eruption relapsed presenting with erythematous macules, tense blisters, and erosions on the trunk and limbs. "

06/01/2004 - "The infected emphysematous bulla was not improved by the administration of antibiotics. "
01/01/2020 - "Previously, antibiotic concentrations in tissues were extrapolated from skin blister studies, but sweat analyses for TDM have not been conducted. "
08/01/2000 - "The pharmacokinetics of this cephem antibiotic were determined in serum and skin suction blister fluid (SBF) after intravenous (i.v.) or intramuscular (i.m.) administration of a single 1 g dose in 8 adult patients with normal renal and hepatic function who volunteered for the study. "
04/01/1995 - "The purpose of this study was to determine the ophthalmic practic patterns regarding long-term antibiotic prophlaxis in eyes with filtration blebs, and the effect of long-term antibiotic usage on conjunctival bacterial flora. "
03/01/1991 - "For the study of the kinetics of the antibiotic in blister fluid a specific kinetic distribution model was employed. "

03/01/2006 - "Bevacizumab may be an effective medication for rescuing failing filtering blebs that exhibit neovascularization."
09/05/2023 - "Results: Bevacizumab significantly reduced postoperative IOP and increased the survival of the filtering bleb, especially in the ED group. "
08/04/2023 - "Bevacizumab was also associated with larger blebs that were less inflamed and required fewer subsequent interventions. "
03/01/2022 - "The vascularity of the central bleb was significantly different between the groups with the Bevacizumab group showing the least vascularity. "
04/01/2020 - "Thirty-one of them had single-dose bevacizumab injection (1.25 mg/0.05 ml) into the bleb area just at the end of the surgery, while 19 eyes did not have. "

01/01/2021 - "Finally, inhibiting PLC or IP3R was protective against PV IgG-induced blister formation and redistribution of Dsg1 and Dsg3 in human skin ex vivo. "
10/01/2008 - "However, when a pathogenic anti-Dsg3 IgG1 mAb (AK23) capable of inducing blisters was injected into AK7-transgenic mice, AK7 B cells were eliminated from the bone marrow (BM) and spleen only when Dsg3 was expressed in the periphery. "
01/01/2020 - "This study establishes a new human ex vivo mucosa model to test pathomechanisms mediated by PV-IgG. The study demonstrates that both AK23 and mucosal-dominant PV induce blisters and associated ultrastructural changes in labial mucosa via a mechanism not dependent on p38MAPK signalling. "
03/01/2004 - "A skin biopsy showed a subepidermal bulla, and a direct immunofluorescence (DIF) study revealed linear deposition of IgG and C3 at the basement membrane zone (BMZ). "
02/15/2003 - "In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation. "

09/01/2022 - "Other risk factors included topical steroid use and irregular ocular surface due to epithelial bullae. "
03/01/2020 - "Due to the inefficacy of local steroids and the emergence of oral and laryngeal blisters, the patient was treated with systemic steroids. "
01/01/2020 - "A male neonate was born with blisters on the trunk to a 37-year-old primigravid woman with a past medical history of recurrent, painful, topical steroid-responsive oral blisters. "
06/01/2018 - "Administration of nonsteroidal antiphlogistic substances or local steroids to the conjunctiva 4 weeks prior to surgery increases long-term success of the filtering bleb function."
02/01/2015 - "In the control group, the new bulla formation was ceased after a mean ± SD of 11.8 ± 4.7 days, and steroid tapering was done after a mean ± SD of 28.3 ± 5.45 days. "

05/22/2023 - "The main outcomes were: intraocular pressure (IOP), microcysts in blebs with AS-OCT and the number of hypotensive eye drops. "
07/01/2022 - "Adherence to a regimen of CS eye drops during the first 5 postoperative weeks; achievement of target intraocular pressure (IOP) at 6 weeks and 6 months to 1 year after surgery; and bleb morphology at 1 year. "
07/01/2022 - "Temporary tarsorrhaphy with topical eye drops was prescribed for a week; however, the bulla persisted. "
06/01/2006 - "They are already part of many preparations: printed blister packages, measures for dosing liquids, applicators for topical use, dosage sprays, and supports for eye drop containers. "
06/01/1996 - "During the follow-up period, postoperative MMC eyedrop was applied, depending on the condition of the filtration bleb. "

12/01/2019 - "In the present study, we demonstrate that the nuclear and Golgi-localized protein BLISTER (BLI) negatively controls the activity of IRE1A/IRE1B under normal growth condition in Arabidopsis. "
01/01/2019 - "These studies suggest proteolytic degradation of anchoring proteins proximal to the DEJ is crucial for dermal-epidermal separation and blister formation. "
01/01/2019 - "Additional genetic studies determined that an IgaA family stress-response protein, GumB, was necessary to induce blebs. "
01/01/1964 - "II. ELECTROPHORETIC AND ULTRACENTRIFUGAL STUDY OF PROTEINS OF THE BLISTER SERUM]."
11/06/2023 - "Together, these data demonstrate that OMVs provide an alternative pathway for the delivery of EHEC T3SS cargo and that vesicle associated effectors are released from OMVs inside host cells and can retain biological activity.IMPORTANCEBacteria can package protein cargo into nanosized membrane blebs that are shed from the bacterial membrane and released into the environment. "

05/01/2015 - "Furthermore, in the mouse model of GFS, clinical investigation of the bleb and a CD31 staining on sections demonstrated that subconjunctival injection of both antibodies similarly improved the surgical outcome (bleb area and survival) by reducing angiogenesis. "
01/01/2021 - "The objective of this study was to calculate BPDAI cut-off values defining mild, moderate and severe BP. We also aimed to assess the interrater reliability and correlation with the number of daily new blisters, and anti-BP180 and anti-BP230 antibodies. "
11/01/2017 - "Anti-BMZ antibodies could be detected in the blister fluid using IIF in all patients in the study group. "
11/01/2017 - "In this study, we evaluated the utility of IIF to detect anti-BMZ antibodies in the blister fluid of patients with sAIBD. "
11/01/2017 - "Previous studies have shown that circulating anti-desmoglein1/3 antibodies are pathogenic and mediate blister formation. "

01/01/2013 - "Fifty-eight of 85 eyes with successful trabeculectomy had significantly greater central and maximal area of the bleb (P<0.001) with decreased vascularity of the central (P=0.02) and peripheral part of the bleb (P=0.03). "
10/01/2008 - "Needle revision of filtering blebs is a useful adjunct to failed, failing, leaking, or dysesthetic trabeculectomy filters and can be performed in a variety of settings and techniques with fairly good results. "
07/01/2008 - "Thus, the slow release of POE/5-CU may be beneficial for the prevention of bleb closure in patients who undergo complicated trabeculectomy."
11/01/2002 - "Patients with a shallow anterior chamber and overfiltrating blebs following a recent trabeculectomy can be treated successfully with a combination of a long acting gas and a viscoelastic material."
09/01/2014 - "This technique is easier, safer, and may be more cost effective for repairing excessive bleb leakage after trabeculectomy than conventional management techniques."

03/01/1999 - "In both cases, intraocular pressure was successfully lowered for 6 months until the occurrence of bleb encapsulation, which was relieved by transconjunctival needling. "
07/01/1985 - "Nine of 13 eyes were treated successfully with primary needling of the bleb. "
08/15/2012 - "It has been suggested that needling of an encapsulated bleb may be effective in re-establishing drainage and lowering intraocular pressure. "
01/01/2004 - "It has been suggested that needling of an encapsulated bleb may be effective in re-establishing drainage and lowering intraocular pressure. "
12/01/2022 - "Bleb needling is a safe and effective procedure for the treatment of failed filtration surgeries."

09/01/2006 - "Needle revision of the filtering bleb is a simple and safe technique that offers good results even years after a filtering surgery had been performed. "
01/01/2019 - "We determined the efficacy of wider area bleb revision after filtering surgery using bleb knife with adjunctive MMC. "
01/01/2017 - "The majority of complications seen in filtering surgery are largely eliminated by the nonpenetrating and bleb-independent approach. "
01/01/2012 - "The majority of complications seen in filtering surgery are largely eliminated by the nonpenetrating and bleb-independent approach. "
07/30/2010 - "Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery."

07/01/2013 - "This phenomenon should be suspected in individuals who present with bullous lesions within 3-8 weeks after initiation of therapy despite of improved immunological response. "
05/01/2023 - "Recently, several studies have focused on eosinophils due to their significant role in the pathogenesis of BP, considering that they are ubiquitous in the serum, tissue, and blister fluids of patients with BP. With this context, precision therapy that targets mediators of eosinophil activity could be a possible novel therapeutic strategy. "
09/07/2021 - "Patients were randomized to a study group who received delivery of their multidrug medical therapy, defined as a minimum of 4 medications daily, in prepackaged blisters or a control group who obtained their prescriptions from their routine pharmacy. "
09/07/2021 - "Impact on patients' compliance with medication using prepacked blisters for multidrug medical therapy: I-COMPLY Study."
01/01/1995 - "In order to study some pharmakokinetic features of RVP application paratibial tissue levels of Netilmycin (NL; from suction blister fluid) and cubital venous NL were compared under each SVI and RVP therapy in 8 patients with DNPU. "

02/01/2002 - "Appropriate laser treatment may be effective in turning a flattened and localized bleb into a good filtering bleb."
01/01/2016 - "Therefore, this study utilized the specific photothermal property of HA-modified GNPs with laser-induced blebs to create a possible new method for medical applications."
07/15/2001 - "Confocal laser microscopic studies indeed suggested that SAP bound to these apoptotic cells mainly via the blebs. "
03/01/1994 - "Quantitative radiographic grading of extent of preoperative pulmonary bullae correlated well with response to laser treatment in patients with preoperative and postoperative studies. "
10/27/2023 - "The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. "