Blister (Bulla)

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4623 relevant articles (159 outcomes, 375 trials/studies) found for this Disease

Description: Visible accumulations of fluid within or beneath the epidermis.

Also Known As:

Bulla; Blisters; Bleb; Bullae; Bullous Lesion; Blebs; Bullous Lesions; Lesion, Bullous; Lesions, Bullous; Vesications; Vesication

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases

Skin Diseases: 5932

Vesiculobullous Skin Diseases: 212

Blister: 4623

Signs and Symptoms Pathological Conditions

Anatomical Pathological Conditions

Blister: 4623

Related Diseases

1.	Blister (Bulla)
2.	Pemphigus (Pemphigus Vulgaris)
3.	Glaucoma
4.	Infection
5.	Emphysema
469 Diseases and 1771 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Nicolau, David P: 5 articles (09/2007 - 05/2003)
2.	Schuman, Joel S: 4 articles (05/2008 - 10/2005)
3.	Kahook, Malik Y: 3 articles (05/2008 - 03/2006)
4.	Noecker, Robert J: 3 articles (05/2008 - 03/2006)
5.	Oshika, Tetsuro: 3 articles (04/2008 - 01/2005)
6.	Kiuchi, Takahiro: 3 articles (04/2008 - 01/2005)
7.	Zijlstra, Freek J: 3 articles (10/2007 - 01/2006)
8.	Zillikens, Detlef: 3 articles (04/2007 - 04/2003)
9.	Matsuo, Hiroshi: 3 articles (10/2005 - 04/2002)
10.	Araie, Makoto: 3 articles (10/2005 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Blister:

1.	Fluorouracil (Carac)FDA LinkGeneric 01/01/2005 - "CONCLUSIONS: 5-FU is safe and does not increase the perioperative risk, and has turned out to be effective in most cases of increased scarring in the filtering bleb site." 12/01/2001 - "In general, eyes implanted with antimetabolite-containing drains demonstrated significantly lower values for all evaluated parameters at 3 months and lower or equal values at 6 months, compared with the eyes not receiving 5-FU and the unoperated controls, indicating improved IOP-lowering function, reduced bleb wall thickness, and earlier achievement of a steady-state wound healing response" 08/01/2004 - "PURPOSE: To determine the efficacy of extensive microsurgical needling revision of failed filtering blebs followed by serial 5-fluorouracil subconjunctival injections" 01/01/1998 - "CONCLUSIONS: This study confirms the effectiveness and relative safety of delayed post-operative 5-FU treatment in patients with clinical evidence of bleb failure" 09/01/2008 - "Conclusion: 5-FU-PLADS displaying sustained intraocular release of 5-FU, reduced intraocular pressure, and prolonged bleb persistence, while significantly reducing 5-FU toxicity." Get all the results and reference details, order at left...
2.	Mitomycin (Mitomycin-C)FDA LinkGeneric 04/01/2006 - "PURPOSE: To study the long-term effectiveness and factors involved in successful needling of failed filtration blebs with mitomycin C (MMC)" 07/01/2008 - "All blebs contained dendritiform inflammatory cells, especially after mitomycin C application" 07/01/2008 - "Numerous goblet cells with immunostaining that was weak or limited to the membrane were clearly visible morphologically at the surface of functioning blebs (with and without adjunctive mitomycin C)" 07/01/2008 - "Eyes were classified into 3 groups: (1) functioning blebs (11 eyes), (2) nonfunctioning blebs (10 eyes), and (3) functioning blebs after mitomycin C application (12 eyes)" 11/01/2007 - "CONCLUSION: In this pilot study, an intraoperative protection of the conjunctival flap from mitomycin contact was mostly associated with a vascularized and thick filtering bleb after mid-term follow-up" Get all the results and reference details, order at left...
3.	Immunoglobulin G (IgG)IBA 10/01/2008 - "However, when a pathogenic anti-Dsg3 IgG1 mAb (AK23) capable of inducing blisters was injected into AK7-transgenic mice, AK7 B cells were eliminated from the bone marrow (BM) and spleen only when Dsg3 was expressed in the periphery" 01/01/2008 - "In both cases, histology revealed subepidermal blisters with mixed inflammatory cell infiltrates containing neutrophils and eosinophils, direct immunofluorescence microscopy studies demonstrated IgG and C3 deposited at the dermoepidermal junctions of perilesional skin, and indirect immunofluorescence studies demonstrated circulating antibasement membrane IgG that bound the dermal side of salt-split skin" 03/01/2004 - "A skin biopsy showed a subepidermal bulla, and a direct immunofluorescence (DIF) study revealed linear deposition of IgG and C3 at the basement membrane zone (BMZ)" 02/15/2003 - "In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation" 01/01/2002 - "Direct immunofluorescence studies showed a weak IgG deposition at the basement membrane zone, in a linear fashion, which was confined to the outer side of the blister" Get all the results and reference details, order at left...
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/2003 - "Bullae recurred and persisted despite systemic corticosteroids" 11/01/1999 - "The bullae were surgically debrided and treatment with oral corticosteroids was started" 07/01/1994 - "Treatment with oral corticosteroids resulted in complete healing, but new blisters subsequently developed on the face, neck and backs of the hands" 01/01/1990 - "Bullous lesions were successfully treated by pulse therapy with high-dose corticosteroids" 09/01/1988 - "Within 24 hours of exposure bullous lesions reappeared in the extremities which again resolved with topical corticosteroids" Get all the results and reference details, order at left...
5.	Complement System Proteins (Complement)IBA 04/01/2001 - "It has been previously suggested that in lupus, autoimmunity develops as a result of inadequate clearance of apoptotic blebs containing nuclear elements; complement deficiencies are the most important hereditary factors predisposing to the inadequate clearance of apoptotic particles" 05/01/1973 - "Our studies, therefore, are suggestive of local activation of the complement sequence, by both the classical and alternate pathways, in blisters of serologically positive bullous pemphigold patients." 01/01/2008 - "This review summarizes the current knowledge on the role the complement system in skin blister formation" 01/01/2008 - "Local complement activation is a common feature for these skin blistering diseases and some complement components are readily detected in the lesional skin and blister fluids" 11/01/1998 - "The colocalization of complement deposition with the acantholytic process in the lower epidermis supports a role for the complement system in blister formation in PV." Get all the results and reference details, order at left...
6.	kalininIBA 04/01/2000 - "These studies demonstrated that neither complement activation nor cross-linking of laminin 5 in epidermal basement membranes was required for induction of subepidermal blister formation in this animal model of a human autoimmune bullous disease." 08/01/2000 - "Basement membrane components were atypically deposited and, at least in the case of laminin-5, improperly processed, leading to disruption of the basement membrane and blister formation at the dermal-epidermal junction" 03/01/1998 - "In 4-day-old blisters, about 20-50 cells at the leading edge of the migrating tongue showed cytoplasmic laminin-5 immunostaining" 05/01/2000 - "Band-like immunostaining in the basement membrane for laminin 5, alpha5 and beta1 chains was continuous in blister bases, but partially discontinuous in open wound bases" 12/01/2006 - "The cutaneous biopsy and ultrastructural and immunohistochemical studies showed a subepidermal bulla in the lamina lucida, absence of hemidesmosomes and marked decrease of laminin 5, thus establishing the diagnosis of Bart syndrome associated to the Herlitz form of lethal junctional epidermolysis bullosa" Get all the results and reference details, order at left...
7.	AntibodiesIBA 05/01/2004 - "Although indirect immunofluorescence (IIF) on serum is a routine test for the detection of basement membrane zone antibodies, there have only been a few studies related to IIF on blister fluid" 01/01/1997 - "An immunocytochemical study using four different APP antibodies demonstrates that these membrane blebs are also associated with a redistribution and an accumulation of cellular APP" 03/01/2008 - "METHODS AND RESULTS: Polyclonal antibodies to InlB and ActA were used in western blotting to determine the effect of selective (BLEB, UVM, and FB) or nonselective (BHI and LB) enrichment broths or hotdog exudates" 03/01/2008 - "Three patients decided to stop taking their medication; subsequently (within 1-2 weeks), blisters recurred, and the levels of antibodies to BP180 increased to close to those before the initiation of treatment" 04/01/2004 - "Patients whose serum contained anti-BPAG2 antibodies had blisters more frequently localized on the head, and a more frequently negative indirect immunofluorescence" Get all the results and reference details, order at left...
8.	TabletsIBA 01/01/2005 - "Unit-dose packaged drugs (in conjunction with prescriber training and patient information) appeared to be associated with higher participant-reported treatment adherence in all trials.A meta-analysis of two trials (596 participants) showed that participant-reported treatment adherence was higher with blister-packed tablets compared with tablets in paper envelopes (RR 1.18, 1.12 to 1.25)" 08/01/2008 - "Drug blisters and tablets often lack the necessary inscriptions to identify them as unit doses" 01/01/2008 - "OBJECTIVE: To evaluate medication adherence and treatment outcomes in elderly outpatients using daily-dose blister packaging (Pill Calendar) compared with medications packaged in bottles of loose tablets" 06/01/2007 - "About 75% of these boxes contained tablets or capsules, mostly in blister packs" 01/01/2007 - "The appearance of tablets and blisters corresponded to the original product" Get all the results and reference details, order at left...
9.	Prednisolone (Predate)FDA LinkGeneric 07/21/2008 - "Infusion of prednisolone at 3.0 or 10 mg/kg significantly suppressed serum AST and ALT, and prevented cell membrane bleb formation" 02/01/2001 - "RESULTS: In the control and prednisolone (1.0 mg/kg) groups, serum AST and ALT levels were elevated, and cell membrane bleb formation was observed after 2 h of reperfusion" 09/01/1999 - "Use of prednisolone blister packs in the field." 01/01/1995 - "After suppression of the asthmatic symptoms for 2 weeks with high-dose prednisolone (25 mg/day), the giant bullae could be resected safely" 04/01/1994 - "METHODS: Twenty-eight patients with pemphigus that was in clinical remission (i.e., patients who were taking low-dose prednisolone [10 mg/day] and had been blister-free for at least 6 months) underwent DIF" Get all the results and reference details, order at left...
10.	Interleukin-5 (Interleukin 5)IBA 07/01/2000 - "Eotaxin and IL-5 levels were increased in the blister fluid compared with the acute and remission phase sera, as well as compared with the sera of normal controls" 07/01/2000 - "PATIENTS/METHODS: In this study we measured eotaxin and IL-5 levels in blister fluid of BP by enzyme-linked immunosorbent assay" 01/01/2004 - "Blister fluid contained even higher amounts of eotaxin and in addition IL-5" 08/01/2002 - "Serum and blister fluid specimens contained elevated MBP, EDN, and interleukin 5 levels and enhanced eosinophil survival in culture" 01/07/2001 - "Significantly increased levels of IL-5 were detected in the serum and particularly the blister fluid of patients with active disease (P=0.0043) when compared to levels in normal controls" Get all the results and reference details, order at left...
1765 Drugs and Important Bio-Agents and 3805 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty) 10/01/2008 - "Needle revision of filtering blebs is a useful adjunct to failed, failing, leaking, or dysesthetic trabeculectomy filters and can be performed in a variety of settings and techniques with fairly good results" 07/01/2008 - "Thus, the slow release of POE/5-CU may be beneficial for the prevention of bleb closure in patients who undergo complicated trabeculectomy." 11/01/2002 - "CONCLUSIONS: Patients with a shallow anterior chamber and overfiltrating blebs following a recent trabeculectomy can be treated successfully with a combination of a long acting gas and a viscoelastic material." 05/01/2001 - "CONCLUSION: Bleb resection associated with the covering of the trabeculectomy site with a rotational conjunctival flap is a safe and effective procedure for the treatment of a late bleb leak and its complications" 04/01/2000 - "CONCLUSIONS: Surgical bleb revisions for complications after trabeculectomy surgery are safe and effective" Get all the results and reference details, order at left...
2.	Lasers (Laser) 02/01/2002 - "CONCLUSION: Appropriate laser treatment may be effective in turning a flattened and localized bleb into a good filtering bleb." 07/15/2001 - "Confocal laser microscopic studies indeed suggested that SAP bound to these apoptotic cells mainly via the blebs" 03/01/2000 - "By means of immunofluorescence flow cytometry and laser scanning confocal microscopy, this study demonstrated that surface expression of the alpha(2)beta(1) (VLA-2) integrin, though absent on blood PMN, is induced in extravasated PMN collected from human skin blister chambers, and rat PMN accumulated in the peritoneal cavity after chemotactic stimulation" 03/01/1994 - "Quantitative radiographic grading of extent of preoperative pulmonary bullae correlated well with response to laser treatment in patients with preoperative and postoperative studies" 04/01/2006 - "PATIENTS AND METHODS: Retrospective review of consecutive patients undergoing laser bleb reductions (LBRs) over a 6-year period" Get all the results and reference details, order at left...
3.	Solid-State Lasers 01/01/2001 - "STUDY DESIGN/MATERIALS AND METHODS: Bullae with broad necks were treated with a Ho:YAG laser thoracoscopically" 01/01/1998 - "STUDY DESIGN/MATERIALS AND METHODS: We used a Ho:YAG laser from August 1994 to April 1997 to treat small pulmonary bullae in 50 patients" 01/01/1998 - "The current study summarizes the data of a 39-month follow-up of patients treated for bullae with a Ho:YAG laser" 10/01/2004 - "Postoperatively, if the filtering bleb tended to decrease or ocular pressure began to increase, the operated trabecular region was reopened with Yag laser" 09/01/2004 - "The authors used frequency-doubled Nd:YAG laser in 3 eyes of 3 patients with large filtering blebs" Get all the results and reference details, order at left...
4.	Transplants (Transplant) 06/01/1997 - "This article describes the surgical repair of eight leaking blebs using a full-thickness scleral graft and analyzes the efficacy of the procedure and its effect on intraocular pressure (IOP) control" 09/01/2000 - "Histological study of the grafts in a group not treated with MMC showed marked cellular infiltration and destruction of islet clusters, whereas that of MMC-treated grafts demonstrated a bleb formation under the kidney capsule, in which islet cell clusters were reorganized, creating a layer of cells fixed to the interior of the bleb" 11/01/2007 - "Surgical Pearl: gloved finger as a transport platform for epidermal graft of suction blister." 06/01/2007 - "Ultrathin Thiersch grafts and suction blister grafts were used" 05/01/2007 - "At day 21, 16/16 test mice developed intense eosinophil infiltration and degranulation of the human mast cells within the grafts and 13/16 developed histological, but not clinically visible, basement membrane blisters" Get all the results and reference details, order at left...
5.	Thoracotomy 05/01/1975 - "Open thoracotomy with resection of obliteration of blebs and parietal pleurectomy provides the best protection against recurrence" 08/01/1996 - "Intracavity suction and drainage is safe and effective treatment of emphysematous bulla in patients considered to be a bad risk for formal thoracotomy." 01/01/2007 - "CASE PRESENTATION: We present a case of seemingly benign epithelial inclusions within the pleura of a sixty year-old male patient who underwent exploratory thoracotomy and subsequent resection of bullous emphysematous blebs" 12/01/2001 - "At re-thoracotomy we confirmed air leakage was occurred from a ruptured bulla that was leaved at first operation." 11/01/2000 - "The surgical procedure performed by traditional thoracotomy, was carried out with the section of the azygos and the resection of small blebs in pulmonary apex" Get all the results and reference details, order at left...
177 Therapies and Procedures and 1320 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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