|3.||Pemphigus (Pemphigus Vulgaris)
|1.||Amagai, Masayuki: 29 articles (07/2015 - 05/2002)|
|2.||Zillikens, Detlef: 28 articles (09/2015 - 03/2002)|
|3.||Hashimoto, Takashi: 24 articles (09/2015 - 07/2002)|
|4.||Sitaru, Cassian: 17 articles (09/2014 - 04/2002)|
|5.||Shimizu, Hiroshi: 14 articles (06/2015 - 07/2005)|
|6.||Zillikens, D: 14 articles (03/2008 - 01/2000)|
|7.||Flynn, Harry W: 13 articles (06/2015 - 04/2002)|
|8.||Ishii, Norito: 13 articles (01/2015 - 03/2010)|
|9.||Diaz, Luis A: 13 articles (01/2012 - 08/2002)|
|10.||Liu, Zhi: 12 articles (01/2012 - 10/2002)|
|1.||Mitomycin (Mitomycin-C)FDA LinkGeneric
10/01/2011 - "To study the effect of topical application of mitomycin C on enhancing the efficacy of needling in the management of bleb failure. "
04/01/2011 - "To assess the efficacy of needle revision using mitomycin C (MMC) for reviving failed filtering blebs during the late postoperative period and its safety for the corneal endothelium. "
08/01/2009 - "Aberrant wound-healing response in mitomycin C-treated leaking blebs: a histopathologic study."
04/01/2006 - "To study the long-term effectiveness and factors involved in successful needling of failed filtration blebs with mitomycin C (MMC). "
01/01/2015 - "To report on long-term outcomes of mitomycin C (MMC)-augmented needle revision of failing deep sclerectomy (DS) blebs. "
|2.||Fluorouracil (Carac)FDA LinkGeneric
12/01/2001 - "In general, eyes implanted with antimetabolite-containing drains demonstrated significantly lower values for all evaluated parameters at 3 months and lower or equal values at 6 months, compared with the eyes not receiving 5-FU and the unoperated controls, indicating improved IOP-lowering function, reduced bleb wall thickness, and earlier achievement of a steady-state wound healing response. "
02/01/2009 - "The efficacy of 5-fluorouracil bleb needling performed 1 year or more posttrabeculectomy: a retrospective study."
02/01/2012 - "Subconjunctival injection of HA-5FU to revive bleb function after bleb needling is as effective as 5FU solution. "
02/01/2009 - "To determine the efficacy of a subconjunctival needling revision using 5-fluorouracil (5FU) when administered to patients who have nonfiltering, flat, or encapsulated blebs over 1 year after the original surgery. "
01/01/2013 - "The study provided evidence that 5-FU and MMC biological delivery membranes could significantly improve the outcome of filtering procedures, the survival of the bleb, and maintenance of lower IOP. "
03/01/2006 - "Bevacizumab may be an effective medication for rescuing failing filtering blebs that exhibit neovascularization."
11/01/2015 - "Both bevacizumab (SC) and MMC 0.02% (2 min) similarly increased bleb area. "
04/01/2015 - "The patients were randomized into 2 cohorts assigned to receive either 1.0 mg (0.04 mL of 25 mg/mL) subconjunctival bevacizumab (treatment group) or 0.04 mL of balanced salt solution (control group) injected in an identical manner posterior to the bleb after the bleb needling. "
02/01/2015 - "Bevacizumab could favor the formation of avascular cystic blebs."
01/01/2015 - "Sequential therapy with multiple agents, including Bevacizumab, prolonged bleb function following GFS in the rabbit model and were significantly better than the negative BSS control. "
|4.||Hyaluronic Acid (Hyaluronan)IBA
12/01/2011 - "Subconjunctival Healon GV in 5-FU-augmented bleb needling revision is a relatively safe and effective technique for reducing IOP in the short to medium term, and it involves few significant complications."
10/01/2013 - "Revision of dysfunctional filtering bleb by conjunctival advancement with bleb preservation and anterior chamber reformation with healon was performed. "
12/01/2011 - "Bleb needling with subconjunctival injection of sodium hyaluronate 1.4%: 1-year outcomes."
02/01/2010 - "We found that CD44-GFP fusion protein was localized in filopodia and in focal bleb-like protrusions where it provided binding sites for hyaluronan. "
12/28/2009 - "A submucosal fluid bleb was created with hyaluronic acid solution. "
|5.||Adrenal Cortex Hormones (Corticosteroids)IBA
09/01/2003 - "Bullae recurred and persisted despite systemic corticosteroids. "
11/01/1999 - "The bullae were surgically debrided and treatment with oral corticosteroids was started. "
07/01/1994 - "Treatment with oral corticosteroids resulted in complete healing, but new blisters subsequently developed on the face, neck and backs of the hands. "
01/01/1990 - "Bullous lesions were successfully treated by pulse therapy with high-dose corticosteroids. "
09/01/1988 - "Within 24 hours of exposure bullous lesions reappeared in the extremities which again resolved with topical corticosteroids. "
|6.||Immunoglobulin G (IgG)IBA
10/01/2008 - "However, when a pathogenic anti-Dsg3 IgG1 mAb (AK23) capable of inducing blisters was injected into AK7-transgenic mice, AK7 B cells were eliminated from the bone marrow (BM) and spleen only when Dsg3 was expressed in the periphery. "
01/01/2008 - "In both cases, histology revealed subepidermal blisters with mixed inflammatory cell infiltrates containing neutrophils and eosinophils, direct immunofluorescence microscopy studies demonstrated IgG and C3 deposited at the dermoepidermal junctions of perilesional skin, and indirect immunofluorescence studies demonstrated circulating antibasement membrane IgG that bound the dermal side of salt-split skin. "
03/01/2004 - "A skin biopsy showed a subepidermal bulla, and a direct immunofluorescence (DIF) study revealed linear deposition of IgG and C3 at the basement membrane zone (BMZ). "
02/15/2003 - "In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation. "
01/01/2002 - "Direct immunofluorescence studies showed a weak IgG deposition at the basement membrane zone, in a linear fashion, which was confined to the outer side of the blister. "
05/01/2015 - "Furthermore, in the mouse model of GFS, clinical investigation of the bleb and a CD31 staining on sections demonstrated that subconjunctival injection of both antibodies similarly improved the surgical outcome (bleb area and survival) by reducing angiogenesis. "
05/01/2004 - "Although indirect immunofluorescence (IIF) on serum is a routine test for the detection of basement membrane zone antibodies, there have only been a few studies related to IIF on blister fluid. "
01/01/1997 - "An immunocytochemical study using four different APP antibodies demonstrates that these membrane blebs are also associated with a redistribution and an accumulation of cellular APP. "
06/01/2015 - "Antibodies against two of these subdomains were injected into mice carrying null mutations of mouse COL7 and the human COL7 transgene and induced subepidermal blisters. "
05/01/2015 - "The passive transfer of antibodies reacting with an N-terminal cleavage site of the mouse COL17 ectodomain into neonatal wild-type mice failed to induce blister formation, even though the antibodies bound to the dermal-epidermal junctions, indicating that cleavage site-specific antibodies have reduced or absent pathogenicity for blister formation. "
|8.||Complement System Proteins (Complement)IBA
04/01/2001 - "It has been previously suggested that in lupus, autoimmunity develops as a result of inadequate clearance of apoptotic blebs containing nuclear elements; complement deficiencies are the most important hereditary factors predisposing to the inadequate clearance of apoptotic particles. "
05/01/1973 - "Our studies, therefore, are suggestive of local activation of the complement sequence, by both the classical and alternate pathways, in blisters of serologically positive bullous pemphigold patients."
01/01/2008 - "This review summarizes the current knowledge on the role the complement system in skin blister formation. "
01/01/2008 - "Local complement activation is a common feature for these skin blistering diseases and some complement components are readily detected in the lesional skin and blister fluids. "
11/01/1998 - "The colocalization of complement deposition with the acantholytic process in the lower epidermis supports a role for the complement system in blister formation in PV."
|9.||Fibrin Tissue Adhesive (Fibrin Sealant)IBA
06/01/2010 - "Conjunctival flap advancement with bleb preservation and adjunctive fibrin glue is a successful technique used for the treatment of bleb dysfunction. "
06/01/2004 - "Use of Tisseel fibrin sealant to manage bleb leaks and hypotony: case series."
09/01/1995 - "Two complete collapses had had only fibrin glue sealant without any resection of bullae. "
11/01/1994 - "Immediately after that, we inserted a chest drainage tube directly into the bulla and instilled fibrin glue through the tube into the bulla. "
05/15/1990 - "Repair of a leaking bleb with fibrin glue."
|10.||Ophthalmic Solutions (Eye Drops)IBA
05/01/2013 - "The maximum and minimum bleb wall thicknesses showed a significant correlation with the number of postoperative glaucoma eye drops (r = 0.452, P<0.001; r = 0.327, P = 0.004). "
11/01/1997 - "The Seidel test was positive in 5 of 96 eyes in which antibiotic eye drops were not used and bleb infection occurred in one of these 5 eyes."
11/01/1997 - "In one of 25 eyes treated with antibiotic eye drops after surgery, the Seidel test was positive and bleb infection occurred. "
11/01/2008 - "Autologous serum eye drops have been reported to be effective for the treatment of severe dry eye-related ocular surface disorders (Sjögren's syndrome), and also other entities such as superior limbic keratoconjunctivitis, graft-versus-host disease, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, recurrent or persistent corneal erosions, neurotrophic keratopathy, Mooren's ulcer, aniridic keratopathy, filtering blebs after trabeculectomy, and post-keratorefractive surgery. "
05/01/2011 - "Postoperative use of 0.5% pirfenidone eye drops was associated with improved trabeculectomy bleb survival in a rabbit model. "
01/01/2013 - "Fifty-eight of 85 eyes with successful trabeculectomy had significantly greater central and maximal area of the bleb (P<0.001) with decreased vascularity of the central (P=0.02) and peripheral part of the bleb (P=0.03). "
10/01/2008 - "Needle revision of filtering blebs is a useful adjunct to failed, failing, leaking, or dysesthetic trabeculectomy filters and can be performed in a variety of settings and techniques with fairly good results. "
07/01/2008 - "Thus, the slow release of POE/5-CU may be beneficial for the prevention of bleb closure in patients who undergo complicated trabeculectomy."
11/01/2002 - "Patients with a shallow anterior chamber and overfiltrating blebs following a recent trabeculectomy can be treated successfully with a combination of a long acting gas and a viscoelastic material."
09/01/2014 - "This technique is easier, safer, and may be more cost effective for repairing excessive bleb leakage after trabeculectomy than conventional management techniques."
09/01/2006 - "Needle revision of the filtering bleb is a simple and safe technique that offers good results even years after a filtering surgery had been performed. "
01/01/2012 - "The majority of complications seen in filtering surgery are largely eliminated by the nonpenetrating and bleb-independent approach. "
01/01/2010 - "Efficacy of amniotic membrane-assisted bleb revision for elevated intraocular pressure after filtering surgery."
11/01/2005 - "In vivo confocal microscopy study of blebs after filtering surgery."
02/01/1997 - "This study shows that a substantial, transient decrease of IOP after DOP occurs in glaucomatous eyes with a well-functioning bleb 3 months to 6 years after filtering surgery. "
06/01/1997 - "This article describes the surgical repair of eight leaking blebs using a full-thickness scleral graft and analyzes the efficacy of the procedure and its effect on intraocular pressure (IOP) control. "
01/01/2012 - "The trial compared two surgical procedures (conjunctival advancement and amniotic membrane transplant) to cover a filtering bleb leak. "
09/01/2000 - "Histological study of the grafts in a group not treated with MMC showed marked cellular infiltration and destruction of islet clusters, whereas that of MMC-treated grafts demonstrated a bleb formation under the kidney capsule, in which islet cell clusters were reorganized, creating a layer of cells fixed to the interior of the bleb. "
04/01/2015 - "Strategy 2 has major advantages as only small blisters are made at the donor site, skilful dissection and physical expansion are not required and the strategy can be scaled to create large-area grafts. "
12/01/2014 - "Therefore, we tried treatment with a suction blister epidermal graft. "
01/01/2010 - "Widely considered the gold standard treatment option for tattoo removal, the use of Q-switched lasers may very rarely result in the formation of large bulla. "
02/01/2002 - "Appropriate laser treatment may be effective in turning a flattened and localized bleb into a good filtering bleb."
07/15/2001 - "Confocal laser microscopic studies indeed suggested that SAP bound to these apoptotic cells mainly via the blebs. "
03/01/2000 - "By means of immunofluorescence flow cytometry and laser scanning confocal microscopy, this study demonstrated that surface expression of the alpha(2)beta(1) (VLA-2) integrin, though absent on blood PMN, is induced in extravasated PMN collected from human skin blister chambers, and rat PMN accumulated in the peritoneal cavity after chemotactic stimulation. "
03/01/1994 - "Quantitative radiographic grading of extent of preoperative pulmonary bullae correlated well with response to laser treatment in patients with preoperative and postoperative studies. "
03/01/2013 - "When this resistance to aqueous humor outflow occurred, Mermoud found TDM resistance could be eliminated by performance of goniopuncture (ab interno Nd:YAG laser membranotomy via gonioprism), to enhance aqueous humor outflow into the filtration bleb. "
02/01/2015 - "This study shows a significant decrease in bulla formation associated with tattoo treatment when fractionated CO2 ablation is added to the picosecond Alexandrite laser, which is consistent with observations from a previous case series. "
09/01/2012 - "Superficial wounding model for epidermal barrier repair studies: comparison of Erbium:YAG laser and the suction blister method."
01/01/1998 - "The current study summarizes the data of a 39-month follow-up of patients treated for bullae with a Ho:YAG laser. "
10/01/2015 - "We report a case of ORN of the posterior maxilla treated with Er: YAG laser and a pedicled buccal fat pad (bichat bulla adipose) flap. "