Blast Injuries

Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)

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Networked: 481 relevant articles (13 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Wounds and Injuries (Trauma)
2.	Shock
3.	Burns
4.	Acute Lung Injury
5.	Headache (Headaches)

Experts

1.	Potter, Benjamin K: 12 articles (01/2019 - 03/2007)
2.	Tribble, David R: 9 articles (01/2022 - 12/2012)
3.	Forsberg, Jonathan A: 7 articles (01/2019 - 01/2012)
4.	Murray, Clinton K: 7 articles (01/2018 - 12/2012)
5.	Elder, Gregory A: 6 articles (01/2021 - 04/2009)
6.	Reiner, Anton: 5 articles (01/2022 - 07/2018)
7.	Bull, Anthony M J: 5 articles (03/2021 - 03/2013)
8.	Ahlers, Stephen T: 5 articles (01/2021 - 01/2012)
9.	De Gasperi, Rita: 5 articles (01/2021 - 01/2012)
10.	Gama Sosa, Miguel A: 5 articles (01/2021 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Blast Injuries:

1.	Explosive Agents (Explosives)IBA 07/01/2013 - "The significant bodily violence and harm to children from blast injuries continue to be substantially caused by unexploded ordnance and improved explosive devices. " 01/01/2013 - "Given the frequent use of improvised explosive devices (IEDs) around the world, the study of traumatic blast injuries is of increasing interest. " 11/01/2011 - "This study is an attempt to understand the effects of an explosive blast in a large animal gyrencephalic brain blast injury model. " 06/01/2009 - "A second objective is to present data that illustrate the capabilities of this model to study the proximal biomechanical causes and the resulting pathophysiological, biochemical,neuropathological, and neurological consequences of explosive blast injury to the swine brain. " 01/01/1999 - "This study included 1303 casualties, wounded by explosive devices and with suspected blast injuries, treated at the Military Medical Academy in Belgrade (MMA) from 1991 to 1994. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2021 - "Patients were severely injured, largely from blast injuries, and all received antibiotics prior to Klebsiella isolation. " 12/01/2010 - "Comparison of vacuum-assisted closure to the antibiotic bead pouch for the treatment of blast injury of the extremity." 02/01/2010 - "We hypothesized that the antibiotic bead pouch would be a viable alternative to the VAC Therapy system for such blast injuries. " 02/01/2010 - "Comparison of vacuum-assisted closure to the antibiotic bead pouch for the treatment of blast injury of the extremity." 11/01/2010 - "baumannii blast injury models, 5 mg/kg A3-APO improved survival and reduced bacterial counts in the blood as well as in the wounds and improved wound appearance significantly better than any other antibiotic treatment. "
3.	SodiumIBA 07/01/2010 - "Morphological changes of the neural cells after blast injury of spinal cord and neuroprotective effects of sodium beta-aescinate in rabbits." 01/01/2022 - "Sodium pyruvate resuscitation significantly improved the mean arterial pressure (MAP), heart rate (HR), pulse pressure (PP), hemodynamic stability (Shock index), and autonomic response (Kerdo index) after the HS and/or blast injury. "
4.	ChitosanIBA 01/01/2018 - "Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway." 01/01/2018 - "To investigate the protective effect of chitosan oligosaccharide (COS) on acute lung injury (ALI) caused by blast injury, and explore possible molecular mechanisms. "
5.	Mitogen-Activated Protein KinasesIBA 01/01/2018 - "COS has protective effects on blast injury-induced ALI, possibly by promoting DDAH1 expression and inhibiting ADMA and mitogen-activated protein kinase pathways."
6.	Losartan (Cozaar)FDA LinkGeneric 01/01/2023 - "To evaluate the efficacy of topical losartan after blast injury-simulating irregular phototherapeutic keratectomy (PTK) in rabbits. "
7.	Pyruvic Acid (Pyruvate)IBA 01/01/2022 - "Sodium pyruvate resuscitation significantly improved the mean arterial pressure (MAP), heart rate (HR), pulse pressure (PP), hemodynamic stability (Shock index), and autonomic response (Kerdo index) after the HS and/or blast injury. "
8.	Tryptamines (Triptans)IBA 06/01/2011 - "Triptan class medications are usually effective for aborting headaches in military troops with chronic PTH attributed to a concussion from a blast injury or non-blast injury. "
9.	Silver Sulfadiazine (SSD)FDA LinkGeneric 01/01/2012 - "We conclude application of silver sulfadiazine cream on facial burn-blast injury tattoos several hours before surgical removal of particles is highly efficacious in facilitating particle removal and attaining a good result following surgical intervention, and primary repair. " 01/01/2012 - "Application of silver sulfadiazine cream with early surgical intervention in patients suffering from combined burn-blast injury facial tattoos." 01/01/2012 - "We report two patients suffering from facial burn-blast injury following dynamite explosion in which after primary stabilization, silver sulfadiazine cream was applied to the wounds and 12 hours later the wounds were cleaned under general anesthesia with vigorous saline solution irrigation and brushing. "
10.	OligosaccharidesIBA 01/01/2018 - "Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway." 01/01/2018 - "To investigate the protective effect of chitosan oligosaccharide (COS) on acute lung injury (ALI) caused by blast injury, and explore possible molecular mechanisms. "

Therapies and Procedures

1.	Tattooing 01/01/2006 - "Effective treatment of permanent tattoos with combustible particles due to blast injuries with a V-shaped device." 01/01/2012 - "In case of blast injuries, traumatic tattoos can result from accidental inclusions of intradermal pigmented particles. " 01/01/2006 - "Permanent tattooing due to blast injuries is a rare condition. " 08/01/2011 - "[Treatment of gunpowder tattoo and foreign bodies after blast injuries]." 10/01/1975 - "Blast injury traumatic tattooing is a discouraging problem, because concomitant injuries so often preclude adequate preventive measures at the time of injury, and treatment is frequently less than satisfactory. "
2.	Surgical Amputation (Amputations) 01/01/2018 - "Even at the close of the recent conflicts in Afghanistan, there were deaths that were deemed "potentially survivable." The purpose of this study is to characterize lower extremity blast injury and to determine if their amputation levels and associated injury characteristics correlate with a higher risk of mortality. " 06/24/2023 - "For blast injuries or amputation, we recommend trimming>4mm and using a vein bypass graft. " 05/01/2023 - "We have determined the rate of UL amputation at any level, in combination with LL amputation as a result of blast injury. " 02/01/2022 - "Calcaneus fractures treated operatively in the military are often caused by blast injuries, and have a high rate of requiring subsequent procedures, amputation, and separation from the military." 01/01/2022 - "Amputation was observed in nine (31%) patients in the PBI group (p=0.003); however, there were no patients with amputations in the secondary blast injury (SBI) group (p=0.002). "
3.	Negative-Pressure Wound Therapy 02/01/2013 - "This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected blast injuries in swine. " 10/01/2017 - "Negative pressure wound therapy in the management of mine blast injuries of lower limbs: Lessons learnt at a tertiary care center." 02/01/2013 - "Treatment of infected soft tissue blast injury in swine by regulated negative pressure wound therapy." 01/01/2010 - "Use of negative pressure wound therapy during aeromedical evacuation of patients with combat-related blast injuries." 10/01/2017 - "The negative pressure wound therapy was helpful in preventing proximal amputations due to mine blast injury and was helpful in satisfactory reconstruction of foot defects."
4.	Resuscitation 11/01/2013 - "The use of anaesthetised animal models, and their respective replacement alternatives, for military purposes -- particularly for blast injury, haemorrhaging and resuscitation training -- is critically reviewed. " 01/01/2012 - "All the patients of gunshots or blast injuries were included if they had a Glasgow Coma Scale score of less than 8 after initial resuscitation and had no other injury that could explain their poor neurological status. " 01/01/2004 - "Operation BRAVA (Blast Resuscitation and Victim Assistance) was conceived as a means of conducting humanitarian assistance, education, and training in the acute surgical management of land mine and other blast injuries. " 12/01/2014 - "Specific risk factors for combat-related IFI include dismounted (patrolling on foot) blast injuries occurring mostly in southern Afghanistan, resulting in above knee amputations requiring resuscitation with large-volume blood transfusions. " 04/19/2023 - "Immunopathological Alterations after Blast Injury and Hemorrhage in a Swine Model of Prolonged Damage Control Resuscitation."
5.	Perforator Flap 10/01/2023 - "The SCIP flap is a versatile flap that can be used in hand reconstruction in blast injuries with good functional outcome and improved cosmesis compared with other perforator flaps for the upper extremity."