Bisphosphoglycerate Mutase (Diphosphoglycerate Mutase)

An enzyme that catalyzes the transfer of phosphate from C-3 of 1,3-diphosphoglycerate to C-2 of 3-phosphoglycerate, forming 2,3-diphosphoglycerate. EC 5.4.2.4.

Also Known As:

Diphosphoglycerate Mutase; Bisphosphoglycerate Synthase; Bisphosphoglyceromutase; Mutase, Bisphosphoglycerate; Mutase, Diphosphoglycerate; Synthase, Bisphosphoglycerate; Diphosphoglyceromutase; 3-Phospho-D-glycerate 1,2-phosphomutase

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Transferases: 3
      - Phosphotransferases (Phosphomutases)
        Bisphosphoglycerate Mutase: 12

Experts

1.	Brown, Benjamin C: 2 articles (01/2022 - 01/2020)
2.	Chen, Changhan: 2 articles (01/2022 - 01/2020)
3.	D'Alessandro, Angelo: 2 articles (01/2022 - 01/2020)
4.	Kellems, Rodney E: 2 articles (01/2022 - 01/2020)
5.	Song, Anren: 2 articles (01/2022 - 01/2020)
6.	Xia, Yang: 2 articles (01/2022 - 01/2020)
7.	Xie, Tingting: 2 articles (01/2022 - 01/2020)
8.	Xu, Ping: 2 articles (01/2022 - 01/2020)
9.	Zhang, Weiru: 2 articles (01/2022 - 01/2020)
10.	Zhang, Yujin: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Polycythemia (Erythrocytosis) 01/01/1984 - "New cases of diphosphoglyceromutase (DPGM) have been detected, associated with erythrocytosis in two unrelated families. " 01/01/1984 - "[Diphosphoglyceromutase deficiency: new cases associated with erythrocytosis]." 01/01/2021 - "Uniparental disomy (UPD) of a novel bisphosphoglycerate mutase (BPGM) mutation leading to erythrocytosis." 04/01/2004 - "Erythrocytosis due to bisphosphoglycerate mutase deficiency with concurrent glucose-6-phosphate dehydrogenase (G-6-PD) deficiency."
2.	Hypoxia (Hypoxemia) 01/01/2022 - "Here, we report that erythrocyte transglutminase-2 (eTG2)-mediated PTM is essential to trigger O2 delivery by promoting bisphosphoglycerate mutase proteostasis and the Rapoport-Luebering glycolytic shunt for adaptation to hypoxia, in healthy humans ascending to high altitude and in two distinct murine models of hypoxia. " 01/01/2004 - "Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivo." 01/01/2020 - "Mechanistically, increased erythrocyte S1P functioning intracellularly activates AMPK (AMP-activated protein kinase) 1α and BPGM (bisphosphoglycerate mutase) by reducing ceramide/S1P ratio and inhibiting PP2A (protein phosphatase 2A), leading to increased 2,3-bisphosphoglycerate (an erythrocyte-specific metabolite negatively regulating Hb [hemoglobin]-O2-binding affinity) production and thus more O2 delivery to counteract kidney hypoxia and progression to CKD. "
3.	Rare Diseases (Rare Disease) 11/15/1992 - "Erythrocyte bisphosphoglycerate mutase (BPGM) deficiency is a rare disease associated with a decrease in 2,3-diphosphoglycerate concentration. "
4.	Uniparental Disomy 01/01/2021 - "Uniparental disomy (UPD) of a novel bisphosphoglycerate mutase (BPGM) mutation leading to erythrocytosis."
5.	Cerebral Malaria 01/01/2020 - "Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia."

Related Drugs and Biologics

1.	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)
2.	AMP-Activated Protein Kinases
3.	Protein Phosphatase 2 (Protein Phosphatase 2A)
4.	Proteasome Endopeptidase Complex (Proteasome)
5.	Annexin A5
6.	Triose-Phosphate Isomerase (Triosephosphate Isomerase)
7.	Thyroid Hormones
8.	Purine-Nucleoside Phosphorylase
9.	Phosphoglycerate Mutase (Phosphoglyceromutase)
10.	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)