|1.||Biliary Tract Neoplasms (Biliary Tract Cancer)
|4.||Gallbladder Neoplasms (Gallbladder Cancer)
|5.||Wilms Tumor (Wilm's Tumor)
|1.||Okusaka, Takuji: 22 articles (09/2015 - 12/2002)|
|2.||Rashid, Asif: 19 articles (01/2012 - 10/2002)|
|3.||Hsing, Ann W: 19 articles (01/2012 - 10/2002)|
|4.||Furuse, Junji: 17 articles (02/2015 - 09/2006)|
|5.||Gao, Yu-Tang: 17 articles (01/2012 - 10/2002)|
|6.||Shen, Ming-Chang: 15 articles (01/2012 - 10/2002)|
|7.||Sasaki, Takashi: 12 articles (12/2014 - 01/2009)|
|8.||Isayama, Hiroyuki: 12 articles (12/2014 - 01/2009)|
|9.||Nakai, Yousuke: 12 articles (12/2014 - 01/2009)|
|10.||Zhang, Bai-He: 12 articles (01/2012 - 05/2005)|
12/01/2002 - "In conclusion, while the best available chemotherapeutic treatment for advanced biliary tract cancer remains to be determined, accumulating data from recent phase II trials suggest that single-agent gemcitabine represents an active and very well-tolerated treatment option. "
04/01/2015 - "S-1 and gemcitabine (GS) combination therapy is a promising treatment for advanced biliary tract cancer (BTC). "
01/01/2010 - "Gemcitabine monotherapy showed modest efficacy with manageable toxicity in patients with biliary tract cancer. "
01/01/2010 - "Fixed-dose-rate gemcitabine: a viable first-line treatment option for advanced pancreatic and biliary tract cancer."
05/01/2006 - "In single-agent therapy, gemcitabine demonstrated moderate efficacy with manageable toxicity in patients with advanced or metastatic biliary tract cancer. "
|2.||Cisplatin (Platino)FDA LinkGeneric
01/01/2008 - "A phase II trial of S-1 and cisplatin in patients with metastatic or relapsed biliary tract cancer."
11/01/2015 - "Feasibility and efficacy of gemcitabine plus cisplatin combination therapy after curative resection for biliary tract cancer."
09/01/2010 - "Many clinical trials show that gemcitabine, which is used as a single agent or combined with other agents (for example, cisplatin), demonstrated high efficacy with manageable toxicity in patients with advanced or metastatic biliary tract cancer. "
08/10/2010 - "A British randomised study of gemcitabine plus cisplatin (GC) combination showed promising results in biliary tract cancer (BTC) patients. "
11/01/2015 - "The aim of this multi-institutional study was to assess the feasibility and the efficacy of gemcitabine plus cisplatin (CDDP) combination therapy (GC therapy) for biliary tract cancer (BTC) in the adjuvant setting. "
|3.||oxaliplatin (Eloxatin)FDA LinkGeneric
02/15/2011 - "Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity."
01/01/2008 - "Phase II trial of S-1 in combination with oxaliplatin in previously untreated patients with recurrent or inoperable biliary tract cancer."
01/01/2015 - "The aim of this study was to determine the therapeutic efficacy and safety of transarterial chemoembolization (TACE) with gemcitabine and oxaliplatin in patients with advanced biliary tract cancer (BTC). "
01/01/2010 - "A multicenter phase II trial with irinotecan plus oxaliplatin as first-line treatment for inoperable/metastatic cancer of the biliary tract."
01/01/2010 - "To evaluate the efficacy and tolerability of oxaliplatin (L-OHP) in combination with irinotecan (CPT-11) as first-line treatment of advanced biliary tract cancer. "
|4.||capecitabine (Xeloda)FDA Link
10/01/2012 - "This multisite study sought to optimize the dosing, schedule, and administration of fixed-dose rate (FDR) gemcitabine plus capecitabine for advanced pancreatic and biliary tract cancers using an alternating-week dose schedule of both agents. "
01/01/2012 - "This phase II trial was conducted to determine the activity and safety of the combination of fixed-dose rate (FDR) gemcitabine and capecitabine in metastatic biliary tract cancer (BTC) patients. "
01/01/2012 - "A phase II trial of fixed-dose rate gemcitabine plus capecitabine in metastatic/advanced biliary tract cancer patients."
08/01/2007 - "Phase II study of capecitabine and cisplatin in previously untreated advanced biliary tract cancer."
02/01/2014 - "Capecitabine and Gemcitabine (CapGem, CG, GemCap) for Advanced Pancreatic and Biliary Tract Cancer."
|5.||cetuximab (Erbitux)FDA Link
01/01/2010 - "Cetuximab-containing therapy might be an effective treatment for advanced biliary tract cancer."
01/01/2010 - "We retrospectively analyzed the outcomes of 5 biliary tract cancer patients receiving cetuximab-containing therapy. "
01/01/2010 - "The aim of this report was to describe our experience of using cetuximab with chemotherapeutics agents to treat advanced-stage biliary tract cancer. "
01/01/2010 - "Preliminary experience of cetuximab in the treatment of advanced-stage biliary tract cancer."
01/01/2006 - "Therefore cetuximab, as a component of palliative chemotherapy in biliary tract cancer, needs further evaluation in prospective randomized trials."
07/29/2014 - "Current data suggest that platinum-based combination therapy is the standard first-line treatment for biliary tract cancer. "
07/01/2014 - "Is there a role for second-line platinum re-challenge in advanced biliary tract cancers?"
02/01/2013 - "Gallbladder cancer (GBC) is highly malignant with a low response rate after chemotherapy and platinum drugs are currently prominent in the treatment of biliary tract cancers. "
09/01/2013 - "Efficacy of gemcitabine plus platinum agents for biliary tract cancers: a meta-analysis."
01/01/2015 - "After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). "
|7.||Fluorouracil (Carac)FDA LinkGeneric
05/01/2004 - "This study shows that GEM/CVI 5-FU is active and well tolerated in advanced and metastatic biliary tract cancers."
05/01/2000 - "The present study was carried out to evaluate the effects of concomitant treatment with 5-FU on radiation-induced cell killing in two established human biliary tract cancer cell lines (Mz-ChA-2 and SK-ChA-1 cells). "
08/01/2006 - "Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment."
05/01/2000 - "These findings suggest that therapy with radiation and 5-FU may be of value as components of multidisciplinary treatment for biliary tract cancer. "
05/01/2000 - "Enhanced radiation killing by 5-fluorouracil of biliary tract cancer cell lines."
|8.||S 1 (combination)IBA
04/01/2013 - "A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer."
01/01/2013 - "The JCOG 0805 study was a randomized Phase II study comparing S-1 monotherapy with gemcitabine plus S-1 combination therapy for unresectable biliary tract cancer. "
12/01/2010 - "A randomized Phase II selection design trial comparing gemcitabine plus S-1 combination therapy with S-1 monotherapy for chemo-naïve unresectable or recurrent biliary tract cancer patients was started in Japan. "
12/01/2010 - "Randomized phase II study of gemcitabine plus S-1 combination therapy vs. S-1 in advanced biliary tract cancer: Japan Clinical Oncology Group Study (JCOG0805)."
12/01/2010 - "Patients with unresectable or recurrent biliary tract cancer are randomized to either gemcitabine plus S-1 combination therapy arm or S-1 monotherapy arm. "
|9.||Leucovorin (Folinic Acid)FDA Link
08/01/2013 - "Hepatic arterial infusion with oxaliplatin and 5-FU/folinic acid for advanced biliary tract cancer: a phase II study."
08/01/2000 - "In relation, we performed a phase II study of 5-FU, modulated with leucovorin, in patients affected by advanced pancreatic or biliary tract cancer. "
04/01/2001 - "We have reported a 33% partial response rate with acceptable toxicity using weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and leucovorin (LV) in patients with far advanced biliary tract cancers (BTC). "
08/01/2000 - "Although the response rate for patients with pancreatic adenocarcinoma is not better than that achieved using 5-FU monochemotherapy, the 32.1% overall response rate achieved in patients with biliary tract cancer suggests that 5-FU modulation with leucovorin is active in biliary tract cancer."
08/01/2000 - "5-Fluorouracil in modulation with intravenous leucovorin is well tolerated by patients with stage IV pancreatic adenocarcinoma or biliary tract cancer. "
|10.||Doxorubicin (Adriamycin)FDA LinkGeneric
12/01/2009 - "Combination chemotherapy of UFT and doxorubicin had minimum activity against advanced biliary tract cancer. "
09/01/2006 - "Combination chemotherapy of UFT and doxorubicin was well tolerated and showed preliminary moderate activity against advanced biliary tract cancer. "
12/01/2009 - "A phase II study of uracil-tegafur plus doxorubicin and prognostic factors in patients with unresectable biliary tract cancer."
09/01/2006 - "Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer."
11/01/1984 - "A phase II trial of the regimen 5-fluorouracil, doxorubicin, and mitomycin C (FAM) was conducted in 17 patients with advanced or recurrent biliary tract cancer. "
|1.||Drug Therapy (Chemotherapy)
10/01/2014 - "S-1 chemotherapy is effective against advanced biliary tract cancer. "
01/01/2013 - "First-line chemotherapy (CT1) is effective in advanced biliary tract cancer (ABTC). "
01/01/2013 - "The GEMFUFOL chemotherapy regimen was generally efficacious and tolerable as a first-line treatment of metastatic biliary tract cancer."
01/01/2014 - "The efficacy of second-line chemotherapy (CT2) after the failure of first-line chemotherapy (CT1) for advanced biliary tract cancer (BTC) has not been established. "
01/01/2015 - "Here, we evaluate clinical trials on chemotherapy for patients with pancreatic or biliary tract cancer after first-line treatment failure. "
|2.||Combination Drug Therapy (Combination Chemotherapy)
12/21/2014 - "Gem-based combination chemotherapy is a potential first-line treatment for advanced biliary tract cancer as a result of improved survival, though with additional toxicity."
09/01/2012 - "Combination chemotherapy has proven beneficial in biliary tract cancer and further improvements may be achieved by individualizing treatment based on biomarkers and by adding biological agents. "
12/21/2014 - "To investigate the efficacy and safety of gemcitabine (Gem)-based combination chemotherapies for the treatment of advanced biliary tract cancer. "
12/01/2009 - "Combination chemotherapy of UFT and doxorubicin had minimum activity against advanced biliary tract cancer. "
10/01/2008 - "[Two cases of advanced biliary tract cancer successfully treated with gemcitabine combination chemotherapy]."
07/01/2012 - "A few randomized controlled trials in patients with limited biliary tract cancer have been reported, but the efficacy of adjuvant chemotherapy could not be clarified. "
01/01/2015 - "Thus, evaluation of adjuvant chemotherapy in biliary tract cancer in a large randomized trial is warranted. "
12/01/2013 - "The aim of this study was to evaluate the outcomes of surgical management followed by adjuvant chemotherapy in patients with biliary tract cancer. "
12/01/2013 - "To date, no randomized controlled trials have assessed adjuvant chemotherapy in patients with biliary tract cancer. "
07/01/2012 - "Overall, the important aspects of adjuvant chemotherapy for biliary tract cancer are to establish well-organized and active clinical trial study groups, to conduct well-designed multicenter randomized controlled trials, and to continue such trials without interruption in the future."
11/01/2015 - "The aim of the present study was to assess clinical outcomes of postoperative radiotherapy for biliary tract cancer patients. "
01/01/2013 - "Patterns of radiotherapy practice for biliary tract cancer in Japan: results of the Japanese radiation oncology study group (JROSG) survey."
03/01/2014 - "To seek for the possible factors influencing overall survival (OS) with radiotherapy (RT) for biliary tract cancer. "
03/01/2014 - "Factors influencing survival outcome for radiotherapy for biliary tract cancer: a multicenter retrospective study."
01/01/2013 - "The patterns of radiotherapy (RT) practice for biliary tract cancer (BTC) in Japan are not clearly established. "
07/01/2012 - "This is the first randomized trial to evaluate the use of immunotherapy in patients with advanced biliary tract cancer."
07/01/2012 - "In biliary tract cancer, few clinical studies evaluating immunotherapy have been reported. "
05/01/2013 - "Current status of immunotherapy for the treatment of biliary tract cancer."
07/01/2012 - "Possibility of immunotherapy for biliary tract cancer: how do we prove efficacy? "
09/01/2013 - "Dendritic cell-based immunotherapy targeting synthesized peptides for advanced biliary tract cancer."