Biliary Atresia

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990 relevant articles (40 outcomes, 94 trials/studies) found for this Disease

Description: Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.

Also Known As:

Atresia, Biliary

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 29

Biliary Tract Diseases: 303

Bile Duct Diseases: 39

Biliary Atresia: 990

Digestive System Abnormalities

Biliary Atresia: 990

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Congenital Abnormalities: 9308

Digestive System Abnormalities

Biliary Atresia: 990

Related Diseases

1.	Liver Diseases (Liver Disease)
2.	Jaundice
3.	Hepatitis
4.	Cholangitis
5.	Fibrosis (Cirrhosis)
163 Diseases and 484 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Poovorawan, Yong: 15 articles (10/2008 - 01/2002)
2.	Chongsrisawat, Voranush: 12 articles (10/2008 - 01/2002)
3.	Chen, Chao-Long: 11 articles (07/2008 - 05/2004)
4.	Vejchapipat, Paisarn: 10 articles (10/2008 - 07/2004)
5.	Chuang, Jiin-Haur: 8 articles (07/2008 - 05/2004)
6.	Huang, Chao-Cheng: 7 articles (07/2008 - 05/2004)
7.	Chittmittrapap, Soottiporn: 6 articles (10/2008 - 07/2004)
8.	Miyano, Takeshi: 6 articles (12/2006 - 07/2002)
9.	Lane, Geoffrey J: 6 articles (12/2006 - 07/2002)
10.	Yamataka, Atsuyuki: 6 articles (12/2006 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Biliary Atresia:

1.	Bile Acids and Salts (Bile Acids)IBA 08/01/1998 - "Hepatic and serum bile acids in five patients with biliary atresia were preoperatively determined by microanalysis using gas chromatography-mass spectrometry with negative ion chemical ionization detection" 03/28/1997 - "The present method was applied clinically to analyze bile acids on a dried blood disc from neonatal patients with congenital biliary atresia and hyper-bile-acidemia." 01/01/1986 - "To elucidate urinary bile acid patterns in patients with biliary atresia (BA), 15 sulfated and nonsulfated bile acids in urine were separately measured by high-performance liquid chromatography" 01/01/1986 - "Sulfated and nonsulfated bile acids in urine of patients with biliary atresia: analysis of bile acids by high-performance liquid chromatography." 06/01/1983 - "Duodenal bile acids in diagnosis of congenital biliary atresia." Get all the results and reference details, order at left...
2.	Cholestyramine (Questran)FDA LinkGeneric 12/01/1978 - "The differentiation of biliary atresia from other diseases is readily achieved, as the administration of cholestyramine for 2-3 weeks causes a marked decrease of serum LP-X in patients with patent extrahepatic bile ducts" 08/01/1987 - "Cholestyramine treatment of 3-7 days did not allow to diagnose all children with extrahepatic biliary atresia" 01/01/1987 - "The effect of cholestyramine on 99mTc-hepatolite cholescintigraphy in diagnosing biliary atresia--a preliminary report]" 12/01/1978 - "In twenty-seven infants with biliary atresia, serum LP-X prior to cholestyramine ranged from 0.87 to 11.42 g/l (mean: 3.43 g/l; the average concentration was significantly lower (P less than 0.001) in males" 07/01/1973 - "Extrahepatic biliary atresia: diagnosis by serum bile acid patterns and response to cholestyramine." Get all the results and reference details, order at left...
3.	Octreotide (Sandostatin)FDA LinkGeneric 04/01/2008 - "CONCLUSION: These results (1) indicate that primary prevention of GI bleeding by sclerotherapy of esophageal varices is technically feasible and fairly effective in infants with biliary atresia and large varices, even in those with end-stage liver disease, (2) suggest that decreasing the risk of bleeding may allow liver transplantation under better conditions, and (3) further suggest that octreotide associated with sclerotherapy lowers the rate of complications." 12/01/2004 - "Herein, the authors report a case of refractory chylous ascites after Kasai operation for biliary atresia, which was treated successfully with subcutaneous octreotide, a synthetic somatostatin analogue" Get all the results and reference details, order at left...
4.	Rifampin (Rifampicin)FDA LinkGeneric 07/01/1993 - "To determine the efficacy of rifampicin as a treatment for refractory pruritus, the medical records of 33 children (median age 25 months, range 4-135; 19 boys) with chronic cholestasis liver disease (21 with Alagille's syndrome, eight with progressive intrahepatic cholestasis, one with extrahepatic biliary atresia, one with an inborn error of bile acid metabolism, and one with cryptogenic cirrhosis) were reviewed retrospectively" 05/01/2008 - "We present a case of a 17-month-old child with congenital biliary atresia with generalized pruritus refractory to treatment with oral antihistamines, topical steroids, cholestyramine, and rifampin but improved remarkably with the addition of naltrexone" Get all the results and reference details, order at left...
5.	BilirubinIBA 05/01/1985 - "Studies on the changes of serum bilirubin level after surgery in biliary atresia." 10/01/2007 - "CONCLUSION: Early predictors of success of the Kasai operation in children with biliary atresia are free tracer excretion as shown by HBSS and a serum bilirubin concentration < 57 micromol/l six weeks after the operation" 01/01/2004 - "CONCLUSIONS: The postoperative serum bilirubin level is the most important predictor of long-term survival in patients with portoenterostomy for biliary atresia" 12/01/2003 - "The serum VIP levels of biliary atresia (BA) patients with favourable outcomes (serum bilirubin < or = 34 micromol/L) were not significantly different from those with unfavourable outcomes (serum bilirubin > 34 micromol/L) (42.95 +/- 14.53 pg/ml vs 66.07 +/- 32.17 pg/ml, p = 0.5)" 08/01/2001 - "CONCLUSIONS: Children with biliary atresia and first EVH episode have a variable prognosis related to total serum bilirubin concentration at the time of the episode." Get all the results and reference details, order at left...
6.	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 07/01/2008 - "CONCLUSION: In this cohort of infants with extrahepatic biliary atresia, ursodeoxycholic acid was not shown to be effective, and its use was associated with a plethora of hepatic and extrahepatic complications." 07/01/2008 - "PURPOSE: The objective of this study is to review ursodeoxycholic acid in infants and children with extrahepatic biliary atresia" 07/01/2008 - "RESULTS: Of 141 infants with extrahepatic biliary atresia, 108 received ursodeoxycholic acid for mean duration +/- SD of 252.6 +/- 544.9 days in a dosage of 20 mg/kg per day" 07/01/2008 - "Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia." 04/01/2006 - "Ursodeoxycholic acid as a supplementary treatment in corrected biliary atresia." Get all the results and reference details, order at left...
7.	Phenobarbital (Luminal)FDA Link 03/01/1996 - "Biliary atresia (BA) is characterized by luminal obstruction of the extrahepatic bile duct with fibrous remnants" 05/01/1992 - "Although biliary atresia is characterized by luminal obstruction of the extrahepatic bile ducts, the etiology and the pathophysiology of the liver are still controversial" 12/01/1989 - "Our results point to hepatobiliary scintigraphy after phenobarbital as the best noninvasive procedure for both diagnosis and postoperative follow-up of biliary atresia" 08/29/1970 - "Phenobarbitone in intrahepatic biliary atresia." 04/01/1994 - "Administration of phenobarbital for 5 days before serial US examination is very useful in the diagnosis of neonatal hepatitis when differentiation between neonatal hepatitis and biliary atresia is impossible because of inability to identify the gallbladder by US alone." Get all the results and reference details, order at left...
8.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 01/01/1996 - "Pharmacokinetics for combination trimethoprim/ sulfamethoxazole (TMP/SMX) was studied in only four patients with biliary atresia (BA): three girls, 6.2,8.0 and 8.2 years of age and one boy 8.4 years of age, as this is an uncommon obstructive anomaly of the extrahepatic biliary system and has been described as having a poor prognosis" 01/01/1996 - "Kinetic effects of trimethoprim-sulfamethoxazole in children with biliary atresia: a new dosing regimen." 03/01/1994 - "Trimethoprim/sulfamethoxazole kinetics in children with biliary atresia." 10/01/1981 - "Trimethoprim-sulfamethoxazole for cholangitis following hepatic portoenterostomy for biliary atresia." 04/01/2003 - "PURPOSE: The aim of this study was to evaluate the efficacy of trimethoprim-sulfamethoxazole (TMP/SMZ) and neomycin as the prophylactic agents against the recurrence of cholangitis in children with biliary atresia (BA) after a Kasai portoenterostomy" Get all the results and reference details, order at left...
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/1997 - "Controversy exists regarding the efficacy of corticosteroids on bile flow after Kasai portoenterostomy in biliary atresia (BA)" 12/01/2007 - "The objective of this study was to evaluate adjuvant corticosteroids after Kasai portoenterostomy for biliary atresia" 12/01/2007 - "Randomized, double-blind, placebo-controlled trial of corticosteroids after Kasai portoenterostomy for biliary atresia." 12/01/2004 - "PURPOSE: Members of the Japanese Biliary Atresia Society were surveyed to determine their current practice regarding early use of corticosteroids after Kasai's operation" 08/01/2007 - "AIM: The role of adjuvant therapy with corticosteroids and choleretics after Kasai portoenterostomy for biliary atresia (BA) remains uncertain" Get all the results and reference details, order at left...
10.	Dinoprostone (PGE2)FDA Link 10/01/1989 - "In conclusion the PGE2 has choleretic action in biliary atresia and could be a coadjuvant treatment to improve the bile flow." 10/01/1989 - "In the last four years PGE2 was used in ten cases with extrahepatic biliary atresia" 10/01/1989 - "We studied the choleretic effect of Prostaglandin E2 (PGE2) in patients with biliary atresia" 10/01/1989 - "Effect of prostaglandin (PGE2) in biliary atresia]" 08/01/1993 - "There is no clinical study proving the efficacy of either bile acids or prostaglandin E2 in biliary atresia" Get all the results and reference details, order at left...
336 Drugs and Important Bio-Agents and 500 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Liver Transplantation 11/01/2000 - "Although the prognosis of biliary atresia has been dramatically improved in the era of liver transplantation, the Kasai operation is still the first line of surgical treatment" 10/21/1995 - "The need for paediatric liver transplantation, which in most paediatric series is the remedy for biliary atresia after Kasai's operation has failed, is not sufficiently covered by organ retrieval at the present time" 03/01/2008 - "BACKGROUND/PURPOSE: Although living-related liver transplantation (LRLT) is effective for patients with biliary atresia (BA) after a failed Kasai operation, the pretransplant factors affecting post-LRLT mortality and the optimal timing of the procedure remain unclear" 03/01/2007 - "BACKGROUND: In developed countries, the outlook for patients with biliary atresia has improved remarkably owing to early referral, good diagnostic facilities and the availability of liver transplantation" 01/01/1994 - "The survival of infants with biliary atresia has improved significantly during the past two decades as a result of modification of the Kasai hepatoportoenterostomy procedure complemented by advances in liver transplantation" Get all the results and reference details, order at left...
2.	Hepatic Portoenterostomy 05/01/1994 - "RESULTS: Hepatic portoenterostomy was successful in 28 (32%) of 87 patients with biliary atresia (all younger than 3 months), and 23 showed improvement following hepatic portoenterostomy; hepatic portoenterostomy failed in 36 patients" 03/01/2001 - "BACKGROUND: The outcome of the hepatic portoenterostomy (Kasai) procedure for biliary atresia is improved when it is performed before 90 days of age" 05/01/1992 - "The prognosis of biliary atresia has been improved after the introduction of Kasai's hepatic portoenterostomy, but there are still many problems to be solved in the treatment of this disease" 06/01/1982 - "Improved results with hepatic portoenterostomy: a reassessment of its value in the treatment of biliary atresia." 06/01/1980 - "Surgical intervention utilizing the Kasai hepatic portoenterostomy has improved the outcome of patients with biliary atresia and provided a population of patients with unique health problems" Get all the results and reference details, order at left...
3.	Laparotomy 07/01/2008 - "The gold standard for diagnosis of biliary atresia was the appearance of the extrahepatic biliary tree via laparotomy" 01/01/2005 - "PURPOSE: Exploratory laparotomy with cholecystocholangiography is often performed for the definitive diagnosis of biliary atresia (BA) when radiological and biochemical studies are inconclusive" 07/01/2008 - "If the triangular cord sign is negative, liver biopsy is indicated; if histopathology reveals signs of biliary atresia, explorative laparotomy is indicated" 09/01/2007 - "The other 26 infants with absent or decompressed gallbladder had laparotomy and OCG, which identified biliary atresia in 16 patients (61%)" 01/01/2005 - "Laparoscopic cholecystocholangiography as an effective alternative exploratory laparotomy for the differentiation of biliary atresia." Get all the results and reference details, order at left...
4.	Sclerotherapy 11/01/1999 - "BACKGROUND/AIMS: To determine the safety and effectiveness of endoscopic injection sclerotherapy (EIS) for children with biliary atresia" 04/01/2008 - "OBJECTIVE: We report the results of prophylactic sclerotherapy in 13 infants with biliary atresia and large varices" 04/01/2008 - "Prophylactic endoscopic sclerotherapy of large esophagogastric varices in infants with biliary atresia." 11/01/1999 - "Endoscopic injection sclerotherapy for esophagogastric variceal bleeding in children with biliary atresia." 05/01/1989 - "These results are better than those following surgical procedures for portal hypertension in biliary atresia, and therefore endoscopic sclerotherapy is recommended as the treatment of choice." Get all the results and reference details, order at left...
5.	Transplants (Transplant) 11/01/2008 - "The most common diagnosis leading to LTx was biliary atresia (56.2%), the median age was 14 months, and 33.5% of the patients received a living-related graft" 09/01/2008 - "Biliary atresia was the most frequent indication for transplant" 09/01/2008 - "METHODS AND RESULTS: Two infants with biliary atresia weighing 5 kg each and aged 6 and 5 months, received split adult liver left lateral segment transplants from deceased donors weighing 55 and 65 kg, respectively" 11/01/2007 - "Biliary atresia: a transplant perspective." 09/01/2007 - "Biliary atresia accounts for at least 50 percent of all liver transplants in children and is characterized by the failure of the bile ducts to develop normally and drain bile from the liver" Get all the results and reference details, order at left...
45 Therapies and Procedures and 570 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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