beta-Lactamases (beta-Lactamase)

Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.

Also Known As:

Networked: 2628 relevant articles (159 outcomes, 239 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brook, Itzhak: 15 articles (08/2018 - 05/2002)
2.	Ko, Wen-Chien: 14 articles (06/2022 - 01/2004)
3.	Paterson, David L: 12 articles (04/2021 - 01/2004)
4.	Jones, Ronald N: 12 articles (04/2014 - 11/2002)
5.	Hsueh, Po-Ren: 11 articles (06/2022 - 09/2003)
6.	Rodríguez-Baño, Jesús: 11 articles (10/2021 - 03/2004)
7.	Park, Wan Beom: 10 articles (09/2020 - 01/2004)
8.	Pitout, Johann D D: 10 articles (07/2011 - 06/2004)
9.	Pascual, Alvaro: 10 articles (05/2010 - 03/2004)
10.	Bonomo, Robert A: 9 articles (01/2021 - 12/2002)

Related Diseases

1.	Infections 09/01/1984 - "Both drugs were very effective in the eradication of uncomplicated gonococcal infections caused by both non-beta-lactamase producing and beta-lactamase producing gonococci. " 03/01/1989 - "Clinical efficacies were judged to be good in 33 cases (97.1%) out of 34 which included 13 cases of 14 with infections caused by beta-lactamase-producing strains of organisms, and successfully cured by this drug. " 01/01/2016 - "The future development of novel agents effective against beta-lactamases producers and their applicability in children is urgently needed to address the challenge of multi-resistant Gram negative infections." 01/01/1987 - "Especially SPCM was effective for infections by PPNG, since it was not resolved by beta-lactamase of N. " 01/01/2016 - "However, this type of spacer may also be useful in the treatment of infections caused by monomicrobial extended spectrum beta-lactamases producing gram-negative bacilli. "
2.	Urinary Tract Infections (Urinary Tract Infection) 03/01/1989 - "In particular, 2 urinary tract infections caused by highly beta-lactamase producing Escherichia coli were improved by the treatment with SBT/ABPC. " 10/01/1984 - "In particular, 7 of 8 urinary tract infections caused by beta-lactamase producing organisms were improved after administration of SBT/CPZ. " 01/01/2023 - "This study aimed to evaluate the demographics, clinical characteristics, risk factors, and antibiotic resistance of pediatric community-acquired urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing uropathogens. " 01/01/2023 - "A previous study has shown that two-thirds of patients with urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae experience recurrence with the same bacteria on subsequent UTI episodes. " 01/01/2022 - "This study aimed to investigate the risk factors for community-acquired urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-positive bacteria in infants. "
3.	Endocarditis 10/01/2022 - "Endocarditis due to extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae is a rare but challenging condition. " 09/01/2021 - "Extended spectrum beta lactamase producing Escherichia coli eustachian valve infective endocarditis." 01/01/2021 - "Infective Endocarditis Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli: A Case Report." 01/01/2020 - "He was diagnosed with a tricuspid valve endocarditis caused by an extended spectrum beta lactamase producing Escherichia coli following positive blood cultures and echocardiography. " 01/01/2020 - "Extended spectrum beta lactamase producing Escherichia coli tricuspid valve endocarditis."
4.	Bacteremia 01/01/2020 - "Bacteremia Caused by Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Vientiane, Lao PDR: A 5-Year Study." 11/21/2019 - "We describe two patients in whom extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. " 07/01/2009 - "A study was designed to characterize extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli isolates causing bacteremia over an 8-year period (2000 to 2007) in a large well-defined geographical region. " 11/01/2008 - "To study the prevalence, risk factors, outcome, and molecular epidemiology in patients with bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae (Kp) (cases), in comparison with patients with bacteremia caused by a susceptible Kp (controls). " 10/01/2007 - "The aim of this study was to determine the prevalence of extended-spectrum beta-lactamases (ESBLs) in nosocomial bacteremia isolates of Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca at Hacettepe University Adult Hospital in Ankara, Turkey. "
5.	Cross Infection (Nosocomial Infection) 06/01/2008 - "It has good efficacy against beta-lactamase and ESBL (extended spectrum beta-lacatamase)-secreting pathogens, and it has shown great promise in management of children with severe and nosocomial infections. " 01/01/2020 - "Metallo-beta-lactamase-producing Acinetobacter spp. is a major challenge for therapeutic treatment of nosocomial infections. " 05/01/2010 - "The present PCR assay was thus easily and quickly performed, and accurately detected Pseudomonas aeruginosa and metallo-beta-lactamase, and it should be helpful in the diagnosis and control of nosocomial infection. " 10/01/2020 - "This study aimed to determine the in vitro activity of CID against two different sets of GNB: i) a random sample of 213 clinical isolates, including 17 extended-spectrum beta-lactamase (ESBL) producers, obtained from intensive care unit patients with nosocomial infections collected during a multicentre surveillance study (set I); and ii) a group of 59 challenge GNB producing various types of carbapenemases (CP; set II). " 11/01/2009 - "The aim of this study was to ascertain the incidence and clinical significance of metallo-beta-lactamases among Enterobacter strains isolated from patients with nosocomial infections. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Ampicillin (Omnipen)
3.	Sulbactam
4.	Carbapenems (Carbapenem Antibiotics)
5.	Clavulanic Acid (Potassium Clavulanate)
6.	Amoxicillin (Wymox)
7.	Cephalosporins (Cephalosporin Antibiotics)
8.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)
9.	Penicillins (Penicillin)
10.	beta-Lactams

Related Therapies and Procedures

1.	Therapeutics
2.	Antibiotic Prophylaxis
3.	Tonsillectomy
4.	Peritoneal Dialysis
5.	Critical Care (Surgical Intensive Care)