Benzopyrene Hydroxylase

A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.

Also Known As:

Networked: 38 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Khushbaktova, Z A: 1 article (12/2021)
2.	Klinnikova, M G: 1 article (12/2021)
3.	Syrov, V N: 1 article (12/2021)
4.	Tornuev, Yu V: 1 article (12/2021)
5.	Tursunova, N V: 1 article (12/2021)
6.	Endo, Kaori: 1 article (05/2009)
7.	Ishida, Yuji: 1 article (05/2009)
8.	Makishima, Makoto: 1 article (05/2009)
9.	Nebert, Daniel W: 1 article (05/2009)
10.	Tateno, Chise: 1 article (05/2009)

Related Diseases

1.	Neoplasms (Cancer) 03/01/1971 - " distribution of benzopyrene hydroxylase in normal, lactating and tumor-bearing Wistar rats has been studied.With" 01/01/1989 - "Benzo(a)pyrene-hydroxylase and amidopyrine-N-demethylase activity varied with tumor pattern. " 01/01/1987 - "The study was concerned with comparison of inducibility index (ii) for benzopyrene-hydroxylase in mitogen-activated lymphocytes in patients with primary cancer of the lung, other cancers (breast, stomach, lower lip, rectum, skin and thyroid gland) and in lymphocytes of blood donors. " 07/01/1983 - "In microsomal fraction of the tumor, one could detect cytochrome P-450 and benzo(a)pyrene hydroxylase (BP hydroxylase) activity. " 06/01/1986 - "The activities of benzo(a)pyrene monooxygenase (EC 1.14.14.1), aminopyrene demethylase, cytochrome P-450 reductase, epoxide hydrolase (EC 3.3.2.3), and UDPglucuronosyl transferase (EC 2.4.1.17) in microsomes from spontaneous tumors relative to those from normal liver were 0.25, 0.43, 1.27, 0.90, and 0.51, respectively. "
2.	Lung Neoplasms (Lung Cancer) 01/01/1987 - "[Determination of benzopyrene-hydroxylase (cytochrome P-450) activity in patients with lung cancer]." 01/01/1987 - "The study was concerned with comparison of inducibility index (ii) for benzopyrene-hydroxylase in mitogen-activated lymphocytes in patients with primary cancer of the lung, other cancers (breast, stomach, lower lip, rectum, skin and thyroid gland) and in lymphocytes of blood donors. " 01/01/1988 - "A human primary lung carcinoma cell line (HPL-R1) established from the tumor biopsy of a lung cancer patient, lacking in cytochrome P1-450 [aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH)], was cloned and used to obtain variants deficient in the expression of thymidine-kinase via treatment with 5-bromo-2'-deoxyuridine, and selection for drug resistance phenotype. "
3.	Carcinogenesis 06/01/1986 - "Due to the low, and apparently non-inducible, levels of benzo[a]pyrene hydroxylase activity and of covalent binding in the colonic mucosa, the administration of benzo[a]pyrene to guinea-pigs fed high-fat or high-cholesterol diets appears unlikely to provide a novel animal model for studies on mechanisms of colon carcinogenesis."
4.	Experimental Liver Neoplasms 03/01/1971 - " the exception of NADPH oxidase, the activities of NADP-cytochrome c reductase, NADPH-ferricyanide reductase, benzopyrene hydroxylase and P-450 were markedly different in liver from Morris hepatoma 7777-bearing Buffalo rat when this was compared with homologous tissue obtained from normal Buffalo rat.Whole" 03/01/1971 - "In our studies, enzymes believed to be directly associated with the electron flow chain of NADPH, ferricyanide reduction, cytochrome c, cytochrome P-450 and substrate hydroxylation have been observed in livers obtained from normal, tumor-bearing and whole body irradiated rats as well as in Morris hepatoma 7777 and dimethyl-amino-biphenyl induced breast tumors.A significant difference appeared to exist in the activity of NADPH oxidase, NADP-ferricyanide reductase and benzopyrene hydroxylase when normal liver was compared with the liver obtained from a breast-tumor-bearing animal. "
5.	Breast Neoplasms (Breast Cancer) 03/01/1971 - "In our studies, enzymes believed to be directly associated with the electron flow chain of NADPH, ferricyanide reduction, cytochrome c, cytochrome P-450 and substrate hydroxylation have been observed in livers obtained from normal, tumor-bearing and whole body irradiated rats as well as in Morris hepatoma 7777 and dimethyl-amino-biphenyl induced breast tumors.A significant difference appeared to exist in the activity of NADPH oxidase, NADP-ferricyanide reductase and benzopyrene hydroxylase when normal liver was compared with the liver obtained from a breast-tumor-bearing animal. "

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	Enzymes
3.	Cytochromes c (Cytochrome c)
4.	NADP (NADPH)
5.	Benzo(a)pyrene
6.	NADPH Oxidases (NAD(P)H oxidase)
7.	Mitogens
8.	Cholesterol
9.	ferricyanide reductase
10.	diphenyl (biphenyl)