Benzomorphans

Morphine derivatives of the methanobenzazocine family that act as potent analgesics.

Also Known As:

Benzomorphan

Networked: 27 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Opiate Alkaloids: 5944
    - Morphinans: 33
      - Benzomorphans: 27
        Pentazocine: 615
        bremazocine: 34
        MR 2266: 18
        Mr 1452: 7
        Phenazocine: 5
        MR 2034: 4
        BIII 890 CL: 3
        BIII 277 CL: 2
        5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride: 1
        ID 1229: 1
        Mr 1268: 1
        2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan
        2'-hydroxy-5,9-dimethyl-8,2-epoxyethano-6,7-benzomorphan
        2,5-dimethyl-9 alpha-ethyl-2'-hydroxy-6,7-benzomorphan
        2,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphan
        2-(2-(4-bromoacetamidophenyl)ethyl)-5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphan
        2-benzyl-9-methyl-6,7-benzomorphan
        3-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl)-N-phenylpropanamide
        3-chlorallyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan
        5,9 alpha-diethyl-2'-hydroxybenzomorphan
        7,8-dihydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-1-ol
        8-amino-3-((tetrahydro-2-furanyl)methyl) benzomorphan
        cogazocine lactate
        etazocine
        fluorophen
        GPA 1657
        MR 1353
        MRZ 2549
        N-(2,4,5-trihydroxyphenethyl)normetazocine
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Morphinans: 33
      - Benzomorphans: 27
        Pentazocine: 615
        bremazocine: 34
        MR 2266: 18
        Mr 1452: 7
        Phenazocine: 5
        MR 2034: 4
        BIII 890 CL: 3
        BIII 277 CL: 2
        5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride: 1
        ID 1229: 1
        Mr 1268: 1
        2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan
        2'-hydroxy-5,9-dimethyl-8,2-epoxyethano-6,7-benzomorphan
        2,5-dimethyl-9 alpha-ethyl-2'-hydroxy-6,7-benzomorphan
        2,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphan
        2-(2-(4-bromoacetamidophenyl)ethyl)-5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphan
        2-benzyl-9-methyl-6,7-benzomorphan
        3-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl)-N-phenylpropanamide
        3-chlorallyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan
        5,9 alpha-diethyl-2'-hydroxybenzomorphan
        7,8-dihydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-1-ol
        8-amino-3-((tetrahydro-2-furanyl)methyl) benzomorphan
        cogazocine lactate
        etazocine
        fluorophen
        GPA 1657
        MR 1353
        MRZ 2549
        N-(2,4,5-trihydroxyphenethyl)normetazocine

Experts

1.	Parenti, Carmela: 2 articles (11/2019 - 01/2012)
2.	Pasquinucci, Lorella: 2 articles (11/2019 - 01/2012)
3.	Turnaturi, Rita: 2 articles (11/2019 - 01/2012)
4.	Bidlack, J M: 2 articles (01/2000 - 01/2000)
5.	Avola, Roberto: 1 article (11/2019)
6.	Caraci, Filippo: 1 article (11/2019)
7.	Chiechio, Santina: 1 article (11/2019)
8.	Gulino, Rosario: 1 article (11/2019)
9.	Parenti, Rosalba: 1 article (11/2019)
10.	Spitale, Federica M: 1 article (11/2019)

Related Diseases

1.	Intracranial Vasospasm 02/01/1983 - "This study provides direct evidence for a distinct PCP receptor on cerebral blood vessels and suggests that certain benzomorphans may produce cerebral vasospasm via PCP-receptor interactions."
2.	Neuralgia (Stump Neuralgia) 11/01/2019 - "Herein, we aimed to study the effects of the benzomorphan ligand LP2, a multitarget MOR/DOR agonist, in an experimental model of neuropathic pain induced by the unilateral sciatic nerve chronic constriction injury (CCI) on male Sprague-Dawley rats. "
3.	Shock 06/01/1989 - "A related benzomorphan-derived opioid antagonist, MR1452, also reduced freezing when given ip prior to shock. " 03/01/1989 - "The behavioral effects of U50,488 [( trans]-3,4-dichloro-N-methyl-N[2-(1- pyrrolidinyl)cyclohexyl]benzeneacetamide), bremazocine, Mr2266 [(-)-5,9-diethyl-2-(3-furylmethyl)-2'-hydroxy-6,7-benzomorphan] and morphine were compared in squirrel monkeys responding under multiple fixed-ratio fixed-interval (FR FI) schedules of food presentation or stimulus-shock termination. " 02/01/1980 - "The hypothesis that the antinociceptive effects of pentazocine, a mixed agonist-antagonist opiate of the benzomorphan class, are mediated by a dual opiate-dopaminergic mechanism was tested using a two-choice procedure in which rats were required to discriminate the presence or absence of shock. "
4.	Cocaine-Related Disorders (Cocaine Addiction) 07/01/2002 - "To obtain benzomorphans with a longer duration of action that may be potential therapeutics for treating cocaine abuse, 8-carboxamidocyclazocine was synthesized. " 01/13/2000 - "Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence." 01/13/2000 - "This report concerns the synthesis and preliminary pharmacological evaluation of a novel series of kappa agonists related to the morphinan (-)-cyclorphan (3a) and the benzomorphan (-)-cyclazocine (2) as potential agents for the pharmacotherapy of cocaine abuse. "
5.	Pheochromocytoma 09/17/1990 - "A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain." 01/01/1984 - "Human pheochromocytoma membranes contained (a) mu binding sites (15 fmoles/mg of protein, KD [3H]etorphine 1.0 nM, [3H]EKC 5.4 nM, [3H]DADLE 5.6 nM); (b) kappa sites (41 fmoles/mg of protein, KD [3H]EKC 1.0 nM); (c) benzomorphan sites (115 fmoles/mg of protein, KD [3H]etorphine and [3H]EKC 1.0 nM). "

Related Drugs and Biologics

1.	Ligands
2.	Phencyclidine Receptors
3.	sigma Receptors (sigma Receptor)
4.	SK&F 10047
5.	Opioid Receptors (Opioid Receptor)
6.	Pentazocine (Talwin)
7.	Narcotic Antagonists (Opioid Antagonists)
8.	Opiate Alkaloids
9.	mu Opioid Receptors (mu Opioid Receptor)
10.	Ethylketocyclazocine

Related Therapies and Procedures

1.	Therapeutics
2.	Intra-Arterial Injections
3.	Drug Therapy (Chemotherapy)
4.	Analgesia