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Behcet Syndrome (Behcet's Syndrome)

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Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.

Also Known As:

Behcet's Syndrome; Behcet Disease; Behcets Syndrome; Triple Symptom Complex; Triple-Symptom Complex

Networked: 109 relevant articles (9 outcomes, 8 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Erythema Nodosum
2.	HIV Infections (HIV Infection)
3.	Vasculitis (Vasculitides)
4.	Wegener Granulomatosis (Wegener's Granulomatosis)
5.	Arthritis (Polyarthritis)

Experts

1.	Yazici, H: 2 articles (07/2007 - 12/2004)
2.	Wernick, Richard: 1 article (06/2010)
3.	Geissal, Erik D: 1 article (06/2010)
4.	Reidy, John: 1 article (04/2010)
5.	Lang-Lazdunski, Loïc: 1 article (04/2010)
6.	D'Cruz, David: 1 article (04/2010)
7.	Attia, Rizwan: 1 article (04/2010)
8.	Yamada, Yukiko: 1 article (03/2010)
9.	Tanaka, Hiroyuki: 1 article (03/2010)
10.	Sugita, Sunao: 1 article (03/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Behcet Syndrome:

1.	Thalidomide (Thalomid)FDA Link 06/01/1985 - "A 14-year-old girl with Behcet's syndrome showed a consistent decrease in Ia+ cells throughout her three-month course of thalidomide therapy. " 03/27/1982 - "[Treatment of Behcet's syndrome with thalidomide]" 11/01/1984 - "[Speculative ameloriation of arthritis in Behcet disease with thalidomide. " 05/01/2000 - "In controlled clinical trials, thalidomide has proven effective in the treatment of erythema nodosum leprosum, oral and oesophageal aphthous ulceration associated with advanced HIV infection and oral ulceration associated with Behcet's syndrome. " 11/01/2003 - "Thalidomide is an effective treatment for several inflammatory and autoimmune disorders including erythema nodosum leprosum, Behcet's syndrome, discoid lupus erythematosus, and Crohn's disease. " Order ALL the reference details at left...
2.	Colchicine FDA LinkGeneric 11/01/1979 - "Colchicine may be effective in controlling cutaneous necrotizing vasculitis and Behcet's syndrome through its effect on polymorphnuclear leukocyte function." 11/01/1998 - "Colchicine is an alkaloid drug commonly used in familial Mediterranean fever (FMF), gout, Behcet's syndrome, psoriasis and Sweet's syndrome. " 10/01/1998 - "Colchicine is used in the treatment of gouty arthritis, familial Mediterranean fever, amyloidosis, Behcet disease and dermatoses. " 11/01/1979 - "Four patients with cutaneous vasculitis and normal levels of serum complement and one patient with vasculitis associated with Behcet's syndrome demonstrated clinical improvement while receiving colchicine. " 06/01/1981 - "Drugs like colchicine known to enhance TxA2 formation and the biological actions of PGE1 were found to be of benefit in Behcet's syndrome, vasculitis, amyloidosis, scleroderma and in controlling the auto-immune disease in adjuvant arthritis in rats, the renal disease in NZB/W mice and passively transferred vasculitis. " Order ALL the reference details at left...
3.	AntigensIBA 07/01/2008 - "One patient with Behcet disease and positive for human leukocyte antigen (HLA)-B51 has not improved after HSCT. " 12/01/2006 - "These results indicate the feasibility of using peptide screening for antigen discovery in central nervous system inflammatory diseases of unknown etiology, such as multiple sclerosis, neurosarcoidosis, or Behcet's syndrome." 06/01/1979 - "Lymphoproliferative responses induced by streptococcal antigens in recurrent aphthous stomatitis and Behcet's syndrome." 05/01/2005 - "Conclusion: (1) The hearing and vestibular disturbances in Behcet's syndrome is more prevalent than previously recognized; (2) Hearing loss in high frequencies in Behcet's patients is an indicator of cochlear involvement in this disease; (3) There is a higher prevalence of central vestibular syndrome in Behcet's patients than it was thought before; (4) HLA-B51 antigen may be able to be a prognostic factor for sensorineural hearing loss in Behcet's patients." 03/01/1993 - "22 patients suffering from Birdshot retinochoroidopathy (10), idiopathic vasculitis (6) and Behcet disease (6) and treated by cyclosporine were tested at regular intervals during 11 to 38 months by the lymphocyte stimulation test (LST) and basophil degranulation test (HBDT) with S retinal antigen. " Order ALL the reference details at left...
4.	SteroidsIBA 01/01/2000 - "The main results were the lack of efficacy of some of the classic treatments for Behcet's syndrome, including colchicine, cyclophosphamide and steroids for eye involvement, azapropazone and colchicine for arthritis and acyclovir, colchicine and topical interpheron for aphthas. " Order ALL the reference details at left...
5.	Prednisone (Sone)FDA LinkGeneric 09/01/1990 - "After the surgical excision of the mediastinal mass (January, 1989) until now, Behcet's syndrome is in complete remission with a low dosage of prednisone." Order ALL the reference details at left...
6.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 07/01/1992 - "Of the 8 patients showing Raynaud's syndrome, 4 patients of scleroderma and 1 patient of multiple myeloma showed no improvement of finger blood flow in the cold exposed hand after 2 weeks of pharmacological therapy, but 1 patient of mixed connective tissue disease, 1 patient of Behcet's syndrome and 1 patient of SLE showed much improved finger blood flow after combined administration of vasodilator, calcium channel blockers and antiplatelet drugs. " Order ALL the reference details at left...
7.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2000 - "The main results were the lack of efficacy of some of the classic treatments for Behcet's syndrome, including colchicine, cyclophosphamide and steroids for eye involvement, azapropazone and colchicine for arthritis and acyclovir, colchicine and topical interpheron for aphthas. " Order ALL the reference details at left...
8.	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 07/01/1992 - "Of the 8 patients showing Raynaud's syndrome, 4 patients of scleroderma and 1 patient of multiple myeloma showed no improvement of finger blood flow in the cold exposed hand after 2 weeks of pharmacological therapy, but 1 patient of mixed connective tissue disease, 1 patient of Behcet's syndrome and 1 patient of SLE showed much improved finger blood flow after combined administration of vasodilator, calcium channel blockers and antiplatelet drugs. " Order ALL the reference details at left...
9.	Ascorbic Acid (Vitamin C)FDA Link 02/01/2001 - "CONCLUSIONS: Vascular endothelial function is impaired in Behcet's syndrome and can be rapidly improved by vitamin C treatment. " Order ALL the reference details at left...
10.	Apazone (Azapropazone)IBA 01/01/2000 - "The main results were the lack of efficacy of some of the classic treatments for Behcet's syndrome, including colchicine, cyclophosphamide and steroids for eye involvement, azapropazone and colchicine for arthritis and acyclovir, colchicine and topical interpheron for aphthas. " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 07/01/2008 - "Three patients (one with Behcet disease, one with Sjögren syndrome, and one with Wegener granulomatosis) entered a sustained remission at 6, 6 and 24 months, respectively, after transplant. " 06/02/2009 - "IMAGE CARDIO MED: Oppression of left main trunk due to pseudoaneurysm with graft detachment in patients with Behcet disease previously treated by the Bentall procedure." Order ALL the reference details at left...
2.	Autologous Transplantation (Autograft) 01/01/2007 - "Prolonged remission of neuro-Behcet disease following autologous transplantation." Order ALL the reference details at left...
3.	Plasma Exchange 09/01/1983 - "Seven patients with Behcet's syndrome were given plasma exchanges (PE). " 05/15/1982 - "[Value of plasma exchange in the treatment of Behcet's syndrome and its eye manifestations]" Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 01/01/2000 - "Pharmacotherapy for Behcet's syndrome." 07/01/2008 - "METHODS: Four patients with refractory SV (two with neurovascular Behcet disease, one with neurovascular Sjögren syndrome, and one with Wegener granulomatosis) were involved in an Institutional Review Board (IRB) and US Food and Drug Administration (FDA) approved phase I clinical trial of high dose chemotherapy and autologous HSCT. " Order ALL the reference details at left...
5.	Immunomodulation 07/01/2007 - "Adamantiades-Behcet disease with retinal involvement is now considered an absolute indication for systemic immunomodulatory therapy. " Order ALL the reference details at left...

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