|1.||Leggio, Lorenzo: 11 articles (05/2015 - 09/2003)|
|2.||Addolorato, Giovanni: 11 articles (04/2013 - 09/2003)|
|3.||Yablon, Stuart A: 9 articles (02/2015 - 10/2004)|
|4.||Stokic, Dobrivoje S: 9 articles (02/2015 - 10/2004)|
|5.||Rolland, Benjamin: 9 articles (01/2015 - 11/2010)|
|6.||Cottencin, Olivier: 9 articles (01/2015 - 11/2010)|
|7.||Kofler, Markus: 9 articles (02/2013 - 01/2009)|
|8.||Deheul, Sylvie: 8 articles (01/2015 - 11/2010)|
|9.||Bordet, Régis: 8 articles (01/2015 - 11/2010)|
|10.||Krach, Linda E: 7 articles (05/2014 - 03/2004)|
04/01/2009 - "Baclofen was effective in 21 of 25 patients and significantly reduced Numeric Rating Scale (pain score, 0-10; P < .0001). "
10/01/2006 - "The good clinical response to treatment of spasticity and rigidity, improved quality of life, pain reduction and patient satisfaction with short length of admission demonstrate the efficacy of intrathecal baclofen therapy. "
09/01/2003 - "Baclofen, a presynaptic muscle relaxant is also beneficial in trigeminal pain. "
01/01/2010 - "The present study indicates that the combined treatment of acupuncture and baclofen is more effective than baclofen treatment alone to reduce pain in patients with non-specific chronic LBP. "
04/01/2011 - "Baclofen is effective in attenuating pain associated responses in an experimental model of FD and appears to act by central mechanisms. "
|2.||Dystonia (Limb Dystonia)
04/21/2003 - "Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved. "
01/01/2015 - "Treatment of severe spasticity and dystonia with intrathecal baclofen (ITB) in children has been shown to be effective and has therefore been employed in the Region of Southern Denmark. "
02/01/1999 - "Chronic intrathecal baclofen therapy via pump has been effective in this case and should be considered as a treatment modality in carefully selected patients with dystonia."
01/01/1992 - "Baclofen can be an effective treatment for childhood dystonia."
01/01/1998 - "Intrathecal baclofen infusion is a promising treatment option for generalized dystonia associated with CP. "
08/01/1992 - "Baclofen dramatically reduced spasms, resulting in more stable ventilation, improved ease of care, reduced distress and better integration into the community. "
07/01/2004 - "The Ashworth scale, the Spasms Frequency Scale, and the FIM motor score showed a significant improvement in all patients after the onset of therapy with baclofen. "
09/01/1997 - "In every case intrathecal baclofen therapy resulted in a statistically significant reduction in upper- and lower-extremity tone, spasm frequency, and reflexes, contributing to improved functional abilities. "
05/01/2003 - "This literature review shows evidence that intrathecally administered baclofen is effective in reducing the positive signs of spasticity (tone, spasms, reflex activity). "
01/01/1990 - "Lioresal is effective in reducing spasms. "
|4.||Cerebral Palsy (Spastic Diplegia)
09/01/2007 - "Intrathecal baclofen (ITB) therapy can be very effective in the treatment of intractable spasticity, but its effectiveness and safety have not yet been thoroughly studied in children with cerebral palsy (CP). "
05/01/2009 - "The results of this randomised controlled trial establish continuous infusion of intrathecal baclofen to be effective in carefully selected children with problems caused by intractable spastic cerebral palsy."
01/01/2015 - "To determine whether intrathecal baclofen is an effective treatment for spasticity in children with cerebral palsy. "
02/01/2010 - "Intrathecal baclofen is an effective treatment for spasticity in patients with cerebral palsy. "
09/01/2008 - "Intrathecal baclofen (ITB) is an effective treatment of spasticity in patients with cerebral palsy. "
|5.||Spinal Cord Injuries (Spinal Cord Injury)
10/01/1987 - "Oral baclofen may be effective in patients with spasticity due to spinal cord injury or disease."
08/01/2002 - "This study demonstrates that chronic intrathecal baclofen infusion is a safe and effective form of treatment of intractable spasticity in patients with spinal cord injury. "
06/01/1993 - "Thus far, intrathecal baclofen administration shows promise in the treatment of spasticity resulting from spinal cord trauma. "
06/01/1993 - "Studies were selected for review if they evaluated intrathecal baclofen in patients with spinal cord injury. "
06/01/2015 - "Baclofen or nNOS inhibitor affect molecular and behavioral alterations evoked by traumatic spinal cord injury in rat spinal cord."
|1.||gamma-Aminobutyric Acid (GABA)
|2.||GABA-B Receptor Agonists
|3.||GABA Agonists (GABA Receptor Agonists)
|7.||Morphine (MS Contin)
|8.||Clonidine (ST 155)
|3.||Transcutaneous Electric Nerve Stimulation (TENS)
|4.||Drug Therapy (Chemotherapy)