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Back Pain (Backache)

Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.

Also Known As:

Backache; Backaches; Pain, Back; Back Ache; Back Pain with Radiation; Back Pain without Radiation; Vertebrogenic Pain Syndrome; Ache, Back; Aches, Back; Back Aches; Back Pains; Pain Syndrome, Vertebrogenic; Pain Syndromes, Vertebrogenic; Pains, Back; Syndrome, Vertebrogenic Pain; Syndromes, Vertebrogenic Pain; Vertebrogenic Pain Syndromes

Networked: 1638 relevant articles (158 outcomes, 210 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoporosis
3.	Compression Fractures (Compression Fracture)
4.	Headache (Headaches)
5.	Low Back Pain (Lumbago)

Experts

1.	Sieper, J: 9 articles (07/2009 - 01/2000)
2.	Ernst, E: 8 articles (05/2007 - 06/2000)
3.	van der Heijde, D: 7 articles (12/2009 - 05/2004)
4.	Braun, J: 7 articles (07/2009 - 01/2000)
5.	Deyo, Richard A: 7 articles (01/2009 - 06/2003)
6.	Ringe, J D: 7 articles (12/2007 - 09/2002)
7.	Takeda, Tsuyoshi: 7 articles (12/2005 - 01/2003)
8.	Iwamoto, Jun: 7 articles (12/2005 - 01/2003)
9.	van der Linden, S: 6 articles (12/2009 - 01/2001)
10.	Uzawa, Mitsuyoshi: 6 articles (12/2005 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Back Pain:

1.	Antidepressive Agents (Antidepressants)IBA 04/01/2007 - "Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial." 11/15/2003 - "OBJECTIVES: To systematically review the efficacy of antidepressants for the treatment of patients with back pain and to determine whether there is evidence that outcomes vary between classes of antidepressants. " 11/15/2003 - "BACKGROUND: Three previous reviews have reached conflicting conclusions regarding the efficacy of antidepressants for patients with back pain. " 01/14/2002 - "OBJECTIVE: To assess the efficacy of antidepressants in treating back pain in adults. " 11/15/2003 - "MATERIALS AND METHODS: Best evidence synthesis of randomized, placebo-controlled trials of oral antidepressive agents in patients with back pain. " Order ALL the reference details at left...
2.	Analgesics (Analgesic Drugs)IBA 07/01/1989 - "In 36% (CL = 22-51%) of patients back pain diminished to the point when only milder analgesics were necessary (partial remission). " 12/01/2009 - "The primary outcome was the incidence of back pain requiring analgesics. " 08/01/2009 - "Analgesics were required for back pain in 67 patients (21.1%). " 05/01/2008 - "With regard to tolerability, 7 patients complained of mild to moderate back pain, controlled with oral analgesics. " 02/01/2007 - "The extent of back pain was evaluated using a visual analog scale, and the consumption of analgesics was also assessed. " Order ALL the reference details at left...
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/01/2002 - "Outcome was good with steroid therapy but back pain was only improved by NSAIDs. " 10/15/2000 - "Efficacy of NSAIDs have been demonstrated in acute back pain with randomised clinical trials. " 04/01/2006 - "omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group." 12/01/2004 - "SUMMARY OF BACKGROUND DATA: There is a lack of information on national prescription patterns of NSAIDs and muscle relaxants among individuals with back pain in the United States. " 12/01/2004 - "OBJECTIVE.: To examine national prescription patterns of nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants among individuals with back pain in the United States. " Order ALL the reference details at left...
4.	Narcotics (Narcotic Analgesics)IBA 01/01/1983 - "Severe, persistent abdominal and back pain requiring narcotics is significantly relieved in approximately 80 percent of patients receiving a pancreatic drainage operation. " 05/01/2001 - "Back pain developed 3 years after the original bypass and was not relieved with narcotics and muscle relaxants. " 05/01/2009 - "Be wary of narcotics to treat back pain." 01/01/2009 - "His only complaint was back pain requiring narcotic analgesics. " 01/01/1999 - "Six weeks after surgery 5 (19.2%) patients who received only narcotics were troubled by persistent back pain. " Order ALL the reference details at left...
5.	duloxetine (Cymbalta)FDA Link 01/01/2007 - "[Treatment of chronic back pain with antidepressant cymbalta: an experimental study]" 06/01/2007 - "Duloxetine significantly improved Visual Analogue Scale scores for back pain and time in pain while awake versus placebo. " 03/01/2005 - "Reductions in overall pain, back pain, and pain while awake were also significantly greater for duloxetine than placebo. " 04/01/2009 - "Overall pain and back pain also improved in patients receiving duloxetine. " 01/01/2005 - "Compared to placebo-treated patients, duloxetine-treated patients experienced greater improvement (P<.05) in the HAMD17 total score at Week 2. The individual symptoms showing the most rapid improvements (Week 1) were depressed mood, guilt, suicidal ideation, work/activities, and psychic anxiety as well as VAS back pain and shoulder pain. " Order ALL the reference details at left...
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/01/2005 - "In this case irradiation and corticosteroids relieved her leg and back pain. " 07/20/2002 - "Marked differences in the reasons for the request were seen in loss of body height, back pain and requests from the patient (indications for general practitioners) and in osteoporotic fractures and the use of corticosteroids (indications for specialists). " 09/01/1994 - "Stepwise logistic analysis revealed that women with vertebral fractures at 85 years of age had more significant back pain, shorter stature, and more often a history of another fracture and/or chronic treatment with corticosteroids. " 11/01/1986 - "[Role of epidural corticoids in the diagnosis and treatment of backache]" 09/01/1985 - "The contraindication of the use of corticosteroids is emphasised when dealing with back pain of unknown aetiology." Order ALL the reference details at left...
7.	Teriparatide (Parathar)FDA Link 01/01/2006 - "INTRODUCTION: Teriparatide [rhPTH (1-34)] reduces fracture risk, and in a published meta-analysis of clinical trials, teriparatide-treated patients had reduced incidence of back pain relative to placebo or to antiresorptive drugs. " 01/01/2006 - "CONCLUSIONS: Teriparatide-treated patients had a reduced incidence of back pain versus those receiving a comparator during an observation encompassing clinical trials plus 30 months of posttreatment observation." 12/01/2009 - "Reduction in fracture rate and back pain and increased quality of life in postmenopausal women treated with teriparatide: 18-month data from the European Forsteo Observational Study (EFOS)." 02/01/2006 - "The rates of back pain, moderate or severe back pain, and severe back pain per 100 patient-years were numerically lower in the teriparatide versus comparator groups in each study. " 01/01/2006 - "RESULTS: Patients in the pooled teriparatide group had reduced risk for any back pain [relative risk, 0.73 (95% CI, 0.61-0.87)], moderate or severe back pain [0.72 (0.58-0.89)], and severe back pain [0.39 (0.25-0.61)] compared with pooled controls, from initiation of the study drug through the end of follow-up. " Order ALL the reference details at left...
8.	C-Reactive ProteinIBA 11/01/2009 - "Immediately after the operation, we calculated a significant reduction of the back pain on the VAS to 1.7, of leukocyte counts and C-reactive protein levels. " 10/01/2002 - "The lumbar back pain improved and there was a decrease in C-reactive protein to the normal range 3 weeks after onset. " 08/01/2009 - "On presentation, 27/38 patients with back pain were afebrile and 2/37 patients had a normal C-reactive protein (CRP) level in the first 24 hours. " 01/01/2009 - "Regression analysis resulted in an index with five variables (total back pain, patient global assessment, duration of morning stiffness, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)). " 10/01/2008 - "Diagnosis was based on a history of back pain, raised C-reactive protein, positive blood cultures, and characteristic magnetic resonance findings. " Order ALL the reference details at left...
9.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 03/01/2006 - "Intranasal calcitonin has no effect on chronic back pain intensity and functional capacity of osteoporotic women regardless of the presence of fractures, degenerative disorders or chronic back pain of non-specific etiology." 03/01/2005 - "These facts suggest that improvement of back pain using calcitonin correlates directly with recovery in functional status, indirectly with recovery in general well being." 01/01/2005 - "Calcitonin is a good option in subjects with back pain because of its analgesic effect. " 09/01/2001 - "Because of the analgesic effect, calcitonin is frequently used in osteoporotic patients with back pain." 03/28/1998 - "Chronic back pain was associated with non-justifiable prescription of calcitonin (odds ratio: 5.2; 95% CI: 1.3-33.4). " Order ALL the reference details at left...
10.	Alendronate (Alendronate Sodium)FDA LinkGeneric 07/01/2001 - "Treatment with alendronate 10 mg/day improved bone density and back pain. " 04/01/2005 - "CONCLUSIONS: The results of this study suggest that whole-body vibration exercise using a Galileo machine appears to be useful in reducing chronic back pain, probably by relaxing the back muscles in post-menopausal osteoporotic women treated with alendronate." 04/01/2005 - "Effect of whole-body vibration exercise on lumbar bone mineral density, bone turnover, and chronic back pain in post-menopausal osteoporotic women treated with alendronate." 12/01/2004 - "This report provides evidence indicating that treatment with oral alendronate may have the potential to decrease bone turnover, improve the lumbar BMD, reduce back pain, and prevent new fragile fractures in premenopausal women with OI type I." 01/10/2000 - "CONCLUSION: In postmenopausal women with preexisting vertebral fracture, alendronate therapy for 3 years reduced the number of days of bed disability and days of limited activity caused by back pain." Order ALL the reference details at left...

Therapies and Procedures

1.	Traction 10/01/2003 - "The efficacy of traction for back pain: a systematic review of randomized controlled trials." 12/16/1995 - "Previous trials to assess the efficacy of lumbar traction for back pain have been methodologically flawed. " 02/01/1995 - "The purpose of this study was to conduct a systematic analysis of the literature to assess the efficacy of traction for patients with neck or back pain. " 06/01/1996 - "Seven of 11 patients treated with intermittent traction 1-2 times weekly improved walking tolerance and reported less back pain. " 03/01/1995 - "The efficacy of traction for lumbar back pain: design of a randomized clinical trial." Order ALL the reference details at left...
2.	Vertebroplasty 01/01/2005 - "In well-selected patients, vertebroplasty offers rapid relief of axial back pain and the potential for improved function." 06/01/2005 - "CONCLUSION: Percutaneous vertebroplasty is a safe and effective procedure in relieving debilitating backache and can be used to treat vertebral lesions in selected cases." 04/01/2005 - "CONCLUSIONS: Vertebroplasty and kyphoplasty appear to be safe and effective in the setting of severe back pain caused by VB fracture that is unresponsive to other therapies, even in the presence of relative contraindications to the procedures." 03/01/2005 - "PURPOSE: The aim of this study is to show the utility of vertebroplasty in the treatment of some types of back pain. " 02/01/2010 - "In the last 10 years the minimal invasive treatment options vertebroplasty (VP) and balloon kyphoplasty (BK) have spread quickly because these procedures appeared to be promising treatments to stop the fracture and vertebral lesion associated back pain and to internally stabilize a fractured vertebral body. " Order ALL the reference details at left...
3.	Laminectomy 04/01/2007 - "A clinical feasibility study showed that patients with severe back pain and lower extremity weakness treated with the peridural formulation, applied over their nerve roots following laminectomy or laminotomy, experienced significantly reduced symptoms when compared with surgery-only controls. " 03/01/1988 - "This study compared the abilities of the MMPI and Millon Clinical Multiaxial Inventory (MCMI), using discriminant analyses, to predict outcome after lumbar laminectomy for chronic back pain. " 06/01/2004 - "Back pain and disability after lumbar laminectomy: is there a relationship to muscle retraction?" 08/01/1992 - "Pseudomeningocele is a rare complication of laminectomy, which can cause recurrent back pain with or without radicular signs. " 05/01/1989 - "Thirteen patients had discogenic back pain, eight with prior failed laminectomy procedures, and five undergoing initial spinal surgery. " Order ALL the reference details at left...
4.	Spinal Manipulation 03/15/1989 - "With the recent increase in scientific research and improved studies in the future, spinal manipulation should be better understood by the medical profession as another option for the treatment of back pain." 05/01/2008 - "With the possible exception of back pain, chiropractic spinal manipulation has not been shown to be effective for any medical condition. " 05/01/2005 - "They were also required to present the evidence from at least two referenced clinical trials of spinal manipulation for back pain and to reach a conclusion about the effectiveness of the intervention. " 01/01/2005 - "METHOD: The UK BEAM trial, a national cluster randomized 3 x 2 x 2 factorial trial, was designed to evaluate three treatments for back pain in primary care: "active management"; randomized by practice; and spinal manipulation and exercise classes, both randomized by individual. " 09/15/1997 - "SUMMARY OF BACKGROUND DATA: Earlier studies on the treatment of back pain by spinal manipulation have shown inconsistent results. " Order ALL the reference details at left...
5.	Massage (Reflexology) 12/01/2008 - "Number of days with back pain in the past four weeks were lower after lessons (compared with control median 21 days: 24 lessons -18, six lessons -10, massage -7) and quality of life improved significantly. " 01/01/2008 - "Number of days with back pain in the past four weeks was lower after lessons (compared with control median 21 days: 24 lessons -18, six lessons -10, massage -7) and quality of life improved significantly. " 03/01/1999 - "Only the massage therapy group, however, reported reduced anxiety, improved mood, better sleep and less back pain by the last day of the study. " 06/03/2003 - "CONCLUSIONS: Initial studies have found massage to be effective for persistent back pain. " 06/03/2003 - "The three RCTs that evaluated massage reported that this therapy is effective for subacute and chronic back pain. " Order ALL the reference details at left...

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