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Azaperone

A butyrophenone used in the treatment of PSYCHOSES.
Also Known As:
Janssen Brand of Azaperone; R-1929; Stresnil; Azaperone Janssen Brand; R1929; 1-Butanone, 1-(4-fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-
Networked: 24 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fuller, Andrea: 1 article (01/2014)
2. Miller, Michele: 1 article (01/2014)
3. Haw, Anna: 1 article (01/2014)
4. Buss, Peter: 1 article (01/2014)
5. Meyer, Leith: 1 article (01/2014)
6. Fleming, Gregory: 1 article (01/2014)
7. Hofmeyr, Markus: 1 article (01/2014)
8. Ruediger, K: 1 article (07/2012)
9. Schulze, M: 1 article (07/2012)
10. Duke-Novakovski, Tanya: 1 article (01/2012)

Related Diseases

1. Hypercapnia
07/01/1994 - "In 48-h-old pigs anesthetized with azaperone-ketamine, neither mild nor severe hypoxia altered Zo, Zm, or pulmonary vascular resistance (PVR), whereas hypercapnia increased Zo by 22% (P < 0.001), which persisted despite a return to normocapnia. "
07/01/1994 - "The purpose of this study was to determine the cumulative effects of brief intervals of hypoxia and hypercapnia on the pulsatile characteristics of the pulmonary arterial circulation of 48-h-old compared with 2-wk-old open-chest Yorkshire pigs while using two different anesthetic regimens: 1) azaperone and ketamine (4 and 12 mg/kg im, respectively) and 2) thiopental sodium (25 mg/kg i.v.). "
06/01/2004 - "White rhinoceros anaesthetised with etorphine and azaperone combination develop adverse physiological changes including hypoxia, hypercapnia, acidosis, tachycardia and hypertension. "
01/01/2014 - "Chemical immobilization with etorphine, azaperone and hyaluronidase, as per standard procedure for the white rhinoceros, caused severe respiratory depression with hypoxaemia (PaO2 = 27 ± 7 mmHg [mean ± SD]), hypercapnia (PaCO2 = 82 ± 6 mmHg) and acidosis (pH =7.26 ± 0.02) in the control trial at 5 min. Compared to pre-intervention values, butorphanol administration (without oxygen) improved the PaO2 (60 ± 3 mmHg, F (3,21) =151.9, p < 0.001), PaCO2 (67 ± 4 mmHg, F (3,21) =22.57, p < 0.001) and pH (7.31 ± 0.06, F (3,21) = 27.60, p < 0.001), while oxygen insufflation alone exacerbated the hypercapnia (123 ± 20 mmHg, F (3,21) = 50.13, p < 0.001) and acidosis (7.12 ± 0.07, F (3,21) = 110.6, p < 0.001). "
2. Acidosis
3. Respiratory Insufficiency (Respiratory Failure)
4. Wounds and Injuries (Trauma)
5. Anoxia (Hypoxia)

Related Drugs and Biologics

1. Etorphine (M99)
2. Butorphanol (BC 2627)
3. Oxygen
4. Hyaluronoglucosaminidase (Hyaluronidase)
5. clopenthixol acetate ester
6. Thiopental (Pentothal)
7. Ketamine
8. metomidate
9. Atropine (Hyoscyamine)
10. Medetomidine

Related Therapies and Procedures

1. Anesthesia
2. Premedication
3. Intramuscular Injections
4. Hemodilution
5. Analgesia