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Avian Sarcoma

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Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.

Also Known As:

Sarcoma, Avian; Avian Sarcomas; Sarcomas, Avian; Rous Sarcoma; Sarcoma, Rous

Networked: 299 relevant articles (0 outcomes, 12 trials/studies) for this Disease, Comments

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Leukemia
3.	Human Influenza (Influenza)
4.	Sarcoma (Soft Tissue Sarcoma)
5.	Infection

Experts

1.	Young, John A T: 10 articles (01/2007 - 01/2002)
2.	Federspiel, Mark J: 6 articles (09/2009 - 08/2004)
3.	Melder, Deborah C: 5 articles (09/2009 - 08/2004)
4.	Delos, Sue E: 5 articles (09/2009 - 03/2002)
5.	White, Judith M: 5 articles (03/2008 - 03/2002)
6.	Barnard, Richard J O: 3 articles (06/2005 - 02/2003)
7.	Narayan, Shakti: 3 articles (10/2004 - 02/2003)
8.	Yang, Xinzhen: 2 articles (08/2007 - 10/2005)
9.	Sodroski, Joseph: 2 articles (08/2007 - 10/2005)
10.	Rong, Lijun: 2 articles (12/2005 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Avian Sarcoma:

1.	AntigensIBA 02/01/1966 - "Immunofluorescent studies of group-specific antigen of the avian sarcoma-leukosis viruses." 06/01/1989 - "NSI stimulated the cell mediated immune response to specific as well as to nonspecific Rous sarcoma antigen. " 05/01/1989 - "Serological examination of serum and feather pulp for presence of avian sarcoma-leucosis gs antigen was simultaneously performed, using the ELISA test. " 01/01/1984 - "An ELISA procedure for the detection of avian sarcoma-leukosis gs antigen in feather pulp of adult birds is described. " 11/15/1977 - "A rat Rous sarcoma line which is intermediate in morphological transformation binds an intermediate amount of this antigen. " Order ALL the reference details at left...
2.	Proteins (Proteins, Gene)IBA 10/01/2007 - "In contrast, fusion induced by the class I fusion proteins of human immunodeficiency virus, avian sarcoma leukosis virus, and influenza virus was independent of the voltage polarity across the target cell. " 01/05/2002 - "Previously we have shown that it is possible to target retroviral vectors to cells using avian sarcoma and leukosis virus (ASLV) receptor-ligand and receptor-single-chain antibody bridge proteins (now designated as GATEs for guided adaptors for targeted entry). " 08/01/1995 - "Furthermore, NIH 3T3 cell lines expressing these chimeric proteins were efficiently infected by subgroup A avian sarcoma and leukosis virus vectors. " 08/01/1995 - "Analysis of these proteins demonstrates that any chimera containing the Tva LDLR repeat motif can specifically bind the envelope protein of subgroup A avian sarcoma and leukosis viruses. " 01/01/1988 - "Avian sarcoma-leukosis virus pol-endo proteins expressed independently in mammalian cells accumulate in the nucleus but can be directed to other cellular compartments." Order ALL the reference details at left...
3.	DNA (Deoxyribonucleic Acid)IBA 09/01/2005 - "We have analyzed the placement of sites of integration of avian sarcoma-leukosis virus (ASLV) and human immunodeficiency virus (HIV) DNA in the draft chicken genome sequence, with the goals of assessing species-specific effects on integration and allowing comparison to the distribution of chicken endogenous retroviruses (ERVs). " 04/26/2005 - "Offset symmetry reflecting the topology of the integration reaction was found for HIV-1 and avian sarcoma/leukosis virus but not murine leukemia virus, suggesting fundamental differences in the way different retroviral integration complexes interact with host-cell DNA." 12/01/1992 - "On the structure, genesis and significance of DNA duplications at the Rous sarcoma proviral insertion sites in Rat-1 cells." 08/01/1992 - "The v-src gene was detected in every DNA from tissues of RSV-inoculated embryos but not in DNAs from tissues of RSV-inoculated chicken except for the DNA from Rous sarcoma. " 09/01/1991 - "Early embryos of the silkworm, Bombyx mori, were injected with plasmid p1,5LTR, harboring DNA copies of the Rous sarcoma long terminal repeats (LTR). " Order ALL the reference details at left...
4.	Glycoproteins (Glycoprotein)IBA 08/01/2004 - "In this study we analyzed conformational states of the transmembrane subunit (TM), the fusion subunit, of the Env glycoprotein of the subtype A avian sarcoma and leukosis virus (ASLV-A). " 09/01/2009 - "The entry process of the avian sarcoma and leukosis virus (ASLV) family of retroviruses requires first a specific interaction between the viral surface (SU) glycoproteins and a receptor on the cell surface at a neutral pH, triggering conformational changes in the viral SU and transmembrane (TM) glycoproteins, followed by exposure to low pH to complete fusion. " 03/01/2008 - "Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency." 10/01/2005 - "To our surprise, we found that a single Env trimer is capable of supporting HIV-1 entry; i.e., T = 1. A similar approach was applied to investigate the entry stoichiometry of envelope glycoproteins from amphotropic murine leukemia virus (A-MLV), avian sarcoma/leukosis virus type A (ASLV-A), and influenza A virus. " 06/14/2005 - "To elucidate the mechanism of virus entry, we have imaged fusion between single virions bearing avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) and the cell membrane. " Order ALL the reference details at left...
5.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 05/01/1988 - "Reverse transcriptase of the avian sarcoma and leukosis retroviruses is a heterodimer composed of a 63-kDa alpha and a 95-kDa beta polypeptide chain, both of which are encoded in the pol gene and are produced by proteolytic processing of a larger precursor. " 01/01/1982 - "Reverse transcriptase associated with avian sarcoma-leukosis viruses. " 01/01/1982 - "Reverse transcriptase associated with avian sarcoma-leukosis viruses. " 01/01/1982 - "Reverse transcriptase associated with avian sarcoma-leukosis viruses. " 02/01/1988 - "Recent studies have predicted that the avian sarcoma-leukosis virus pol precursor protein undergoes a previously undetected processing event resulting in the formation of common C termini for the endonuclease (pp32) and the beta subunit of reverse transcriptase (F. " Order ALL the reference details at left...
6.	Mitochondrial DNA (mtDNA)IBA 04/01/1992 - "Oncogenic transformation of CEF by Rous sarcoma viruses results in a threefold elevated level of aMDP1, directly correlating with a similarly increased level of mtDNA replication in vivo. " 10/01/1983 - "The effect of transformation by oncogenic Rous sarcoma viruses on the replication of mitochondrial DNA (mtDNA) in chick embryo fibroblasts (CEF) was investigated, extending our previous report of a three- to five-fold increase in the rate of mtDNA replication, which is strictly linked to the expression of the transformed state, is mitochondria-specific, and is not attributable to virus production per se or different growth rates between normal and transformed CEF. " 12/01/1976 - "Specific changes in the synthesis of mitochondrial DNA in chick embryo fibroblasts transformed by Rous sarcoma viruses." 02/04/1977 - "Studies on the synthesis and structure of mitochondrial DNA in cells infected by Rous sarcoma viruses and on the occurrence of intramitochondrial virus-like particles in certain RSV-induced tumor cells." Order ALL the reference details at left...
7.	Glucose (Dextrose)FDA LinkGeneric 10/15/1960 - "Effect of glucose concentration on respiration of Rous sarcoma and of chorioallantoic membrane." 01/01/1959 - "Decrease of respiration by glucose (crabtree effect) in Rous sarcoma of chorioallantoic membrane." 01/01/1986 - "Our results suggest that at least Rous sarcoma tumor effectively converts [18F]FDG to [18F]FDG-6-P and thus PET studies with [18F]FDG can be applied to tumor diagnosis and to quantitative measurement of glucose utilization in tumor tissue according to the model of Sokoloff." Order ALL the reference details at left...
8.	DNA Restriction Enzymes (Restriction Endonuclease)IBA 01/01/1988 - "Southern blot study of genomic DNAs digested with several restriction endonucleases showed that the banding patterns of the HLA genes were not altered in the cells harboring the Rous sarcoma provirus. " 01/01/1987 - "Restriction endonuclease cleavage analysis and blotting hybridization of nuclear DNA and RNA to cloned avian sarcoma and murine leukemia virus genes (pol, scr and abl) demonstrated the presence and expression in baker's yeast cells of retrovirus-specific sequences. " Order ALL the reference details at left...
9.	phosphoprotein 32IBA 02/01/1988 - "Recent studies have predicted that the avian sarcoma-leukosis virus pol precursor protein undergoes a previously undetected processing event resulting in the formation of common C termini for the endonuclease (pp32) and the beta subunit of reverse transcriptase (F. " 07/01/1988 - "The gag-pol precursor protein of the avian sarcoma-leukosis virus is processed into three known pol-encoded mature polypeptides; the 95- and 63-kilodalton (kDa) beta and alpha subunits, respectively, of reverse transcriptase and the 32-kDa pp32 protein. " 07/01/1988 - "Both possess DNA endonuclease activity and, like the pp32 protein isolated from virions, can cleave near the junction of two tandem avian sarcoma-leukosis virus long terminal repeats in double-stranded supercoiled DNA substrates. " Order ALL the reference details at left...
10.	vif Gene ProductsIBA 09/01/2002 - "This study demonstrates that (i) purified recombinant Vif protein and HIV-1 but not avian sarcoma leukaemia virus protease specifically bind each other and (ii) the interaction between these two proteins takes place at the N terminus of the protease (aa 1-9) and the central part of Vif (aa 78-98). " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 08/01/1965 - "The induction of the Rous sarcoma in heterologous transplants of virus-infected adult chicken tissue." 08/01/1986 - "Immunologic studies failed to detect group-specific (gs) antigen of the avian sarcoma-leukemia complex in either RSV-M-induced, transformed cells or tumor transplants. " Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 07/01/1956 - "[Results of heterogenic transplantation of Rous sarcoma in decerebrated and normal pigeons.]" 11/01/1969 - "Induction of transplantation resistance to Rous sarcoma isograft by avian leukosis virus." 10/01/1953 - "Transplantation of the Shope papilloma and the Rous sarcoma during early developmental stages." 03/01/1967 - "Detection of avian leukosis viremia in chicks by transplantation of Bryan strain Rous sarcoma hamster tumors." 03/01/1979 - "Immunization of mice with MC-29 hepatoma antigen and immunization with chicken Rous sarcoma gave similar results; both elicited much less transplantation resistance than immunization with irradiated RSV(SR) mouse tumor cells. " Order ALL the reference details at left...
3.	Thymectomy 01/01/1984 - "The results show that thymectomy has considerable effect on growth of RSV-induced tumours in the CB line genetically resistant to progressive Rous sarcoma growth and little effect in (CB X IC)F1 (also genetically resistant) and (CC X IC)F1 (intermediate responders to RSV) hybrid chickens. " 01/01/1967 - "[The effect of thymectomy on the growth of Rous sarcoma in chicks]" Order ALL the reference details at left...
4.	Isogeneic Transplantation 11/01/1969 - "Induction of transplantation resistance to Rous sarcoma isograft by avian leukosis virus." Order ALL the reference details at left...

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