Autistic Disorder (Autism)

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1849 relevant articles (121 outcomes, 411 trials/studies) found for this Disease

Description: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-IV)

Also Known As:

Autism; Disorders, Autistic; Autism, Early Infantile; Autisms; Disorder, Autistic; Early Infantile Autism; Infantile Autism; Infantile Autism, Early; Kanner Syndrome; Kanners Syndrome; Syndrome, Kanner's; Autism, Infantile; Kanner's Syndrome

Relationship Network

Disease Context: Research Results

Mental Disorders: 1707

Mental Disorders Diagnosed in Childhood

Pervasive Child Development Disorders: 3

Autistic Disorder: 1849

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Mental Retardation (Idiocy)
3.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
4.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
5.	Alzheimer Disease (Alzheimer's Disease)
237 Diseases and 585 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	McDougle, Christopher J: 18 articles (08/2008 - 07/2002)
2.	Posey, David J: 15 articles (06/2008 - 07/2002)
3.	Tierney, Elaine: 12 articles (06/2008 - 08/2002)
4.	Scahill, Lawrence: 11 articles (06/2008 - 08/2002)
5.	Hollander, Eric: 11 articles (04/2008 - 07/2003)
6.	Arnold, L Eugene: 10 articles (06/2008 - 08/2002)
7.	Vitiello, Benedetto: 10 articles (06/2008 - 08/2002)
8.	McCracken, James T: 9 articles (06/2008 - 08/2002)
9.	Aman, Michael G: 9 articles (06/2008 - 08/2002)
10.	Niederhofer, Helmut: 8 articles (01/2008 - 12/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autistic Disorder:

1.	Risperidone (Risperdal Consta)FDA Link 08/01/2002 - "The efficacy of risperidone in the treatment of very young children with autistic disorder reported here is consistent with findings in the limited number of cases previously reported in the literature" 02/01/2007 - "Risperidone treatment was well tolerated and significantly improved behavioral problems associated with autism." 01/01/2007 - "AUTHORS' CONCLUSIONS: Risperidone can be beneficial in some features of autism" 06/01/2006 - "Risperidone improved global functioning and social responsiveness while reducing hyperactivity and aggression in children with autism and was well tolerated." 06/01/2006 - "In the risperidone group, 12 of 19 children showed improvement in the total Childhood Autism Rating Scale score and 17 of 19 children in the Children's Global Assessment Scale score compared with 0 of 20 children for the Childhood Autism Rating Scale score and 2 of 20 children for the Children's Global Assessment Scale score in the placebo group (P < .001 and P = .035, respectively)" Get all the results and reference details, order at left...
2.	Secretin FDA Link 12/09/1999 - "After recent publicity about a child with autism whose condition markedly improved after a single dose of secretin, thousands of children with autistic disorders may have received secretin injections" 01/01/2005 - "Is secretin effective in treatment for autism spectrum disorders (ASD)?" 12/09/1999 - "CONCLUSIONS: A single dose of synthetic human secretin is not an effective treatment for autism or pervasive developmental disorder." 07/01/2002 - "A number of controlled clinical trials did not show improvement in autistic symptoms with secretin compared with placebo, possibly indicating no role for the drug in autistic disorder." 06/01/2002 - "To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin" Get all the results and reference details, order at left...
3.	Serotonin (5 Hydroxytryptamine)IBA 05/01/1997 - "Recent studies suggest that serotonin re-uptake inhibitors are helpful in at least some symptoms of autism" 09/01/2006 - "In this study, plasma serotonin levels in autism mothers and control mothers of typically developing children were compared, and plasma serotonin levels in children with autism (n = 17) and their family members were measured" 03/25/2005 - "Some studies have suggested that disorders in the peripheral and central metabolism of serotonin (5-HT) may play a role in the pathophysiology of autistic disorder" 09/01/2004 - "This study provides further evidence for altered 5-HT sensitivity in individuals with autism spectrum disorders, as well as a possible relationship between repetitive behaviours in autism spectrum disorders and abnormalities in the 5-HT system." 01/01/2004 - "The aim of this study was to determine 5-HT levels in platelet-poor plasma (PPP) in a group of adult patients with autism" Get all the results and reference details, order at left...
4.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2004 - "CA may be recommended for combined therapy with neuroleptics as an effective and safe medicine for the treatment of cognitive and behavioral disorders in patients with children's autism." 12/04/2000 - "While recruiting patients with COS refractory to conventional treatments for a trial of atypical antipsychotic drugs, we discovered a unique case who has a familial t(1;7)(p22;q21) reciprocal translocation and onset of psychosis at age 9. The patient also has symptoms of autistic disorder, which are usually transient before the first psychotic episode among 40-50% of the childhood schizophrenics but has persisted in him even after the remission of psychosis" 08/01/2007 - "Earlier studies investigating basal ganglia in autism have included subjects on neuroleptics known to affect basal ganglia volumes" 04/01/2007 - "STUDY SELECTION AND DATA EXTRACTION: Relevant data were extracted from studies of selected atypical antipsychotics in the treatment of autistic disorder in children, adolescents, and adults" 01/01/2008 - "Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism" Get all the results and reference details, order at left...
5.	Fluvoxamine (Luvox)FDA LinkGeneric 11/01/1996 - "CONCLUSIONS: Fluvoxamine is more effective than placebo in the short-term treatment of the symptoms of autistic disorder in adults" 10/01/2000 - "One controlled study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive phenomena and aggression in adults with autistic disorder" 11/01/1996 - "A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder." 06/01/2005 - "Eighteen children with autistic disorder completed a 12-week double-blind, placebo-controlled, randomized crossover study of fluvoxamine" 05/01/2003 - "Twenty-eight subjects, consisting of 23 boys and 5 girls, aged from 3 to 18 years old diagnosed as having autistic disorder were analyzed during fluvoxamine administration" Get all the results and reference details, order at left...
6.	Clomipramine (Anafranil)FDA LinkGeneric 07/01/1992 - "Four of five outpatients with autistic disorder showed significant improvement in social relatedness, obsessive compulsive symptoms, and aggressive and impulsive behavior with clomipramine treatment" 07/01/1992 - "This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder" 04/01/1996 - "OBJECTIVE: To assess the short-term efficacy and safety of clomipramine in hospitalized young children with autism" 07/01/1992 - "Clomipramine in autism: preliminary evidence of efficacy." 07/01/1994 - "Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation." Get all the results and reference details, order at left...
7.	Vitamin B 6IBA 03/01/2006 - "Previous studies reported positive results with the use of Mg-vitamin B6 in autism" 01/01/2006 - "This may explain the many published studies of benefits of high-dose vitamin B6 supplementation in some children and adults with autism." 01/01/2006 - "This includes the data from 24 children with autism from our previous study.) METHODOLOGY: A microbiologic assay was used to measure the level of total vitamin B6 (including phosphorylated and unphosphorylated forms), in a blinded fashion" 01/01/2006 - "OBJECTIVE: The aim of this study was to investigate the biochemical basis for vitamin B6 therapy by measuring the level of total vitamin B6 in the plasma of unsupplemented children with autism spectrum disorder compared to unsupplemented control subjects" 01/01/2006 - "BACKGROUND: There have been many studies of the effect of high-dose supplementation of vitamin B6 on children and adults with autism, with all but one reporting benefits" Get all the results and reference details, order at left...
8.	MagnesiumIBA 02/01/2006 - "Magnesium profile in autism." 02/01/2006 - "Genotyping data obtained from the 2 mM magnesium protocol increased the significance of linkage and gave suggestive (P=0.06) association with autism spectrum disorder, whereas the corrected genotypes of 5-HTTLPR provide no linkage information beyond the results we have previously published and no evidence of association with autism spectrum disorder" 08/01/1997 - "Several reports have described salutary effects such as decreased physical aggression and improved social responsiveness being associated with the administration of high doses of pyridoxine and magnesium (HDPM) in open-labeled and controlled studies of patients with autism" 01/01/2005 - "OBJECTIVES: To determine the efficacy of vitamin B6 and magnesium (B6-Mg) for treating social, communication, and behavioural responses of children and adults with autism" 01/01/2002 - "OBJECTIVES: To determine the efficacy of vitamin B6 and magnesium (B6-Mg) for treating social, communication and behavioural responses of children and adults with autism" Get all the results and reference details, order at left...
9.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/01/2001 - "Recent reports suggest that selective serotonin reuptake inhibitors (SSRIs) are useful in the treatment of individuals with autism and other pervasive developmental disorders" 01/01/1997 - "Recent studies suggest that serotonin reuptake inhibitors are helpful in at least some symptoms of autism" 07/15/2006 - "Hyperserotonemia has been consistently found in a proportion of autistic patients, and the use of selective serotonin reuptake inhibitors (SSRIs) can have a positive effect in treating some symptoms of autism" 03/01/2006 - "Selective serotonin reuptake inhibitors in autism: a review of efficacy and tolerability." 02/01/2006 - "This paper reviews the published literature on the use of selective serotonin reuptake inhibitors (SSRIs) for the treatment of symptoms associated with autistic disorder and other pervasive developmental disorders (PDDs) in both children and adults" Get all the results and reference details, order at left...
10.	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/01/2002 - "The serotonin transporter gene (SLC6A4, MIM 182138) is a candidate gene in autistic disorder based on neurochemical, neuroendocrine studies and the efficacy of potent serotonin transporter inhibitors in reducing ritualistic behaviors and related aggression" 05/01/1997 - "The serotonin transporter gene (HTT) is a primary candidate in autistic disorder based on efficacy of potent serotonin transporter inhibitors in reducing rituals and routines" 05/01/2006 - "The results of previous reports about family-based association studies between the serotonin transporter (5-HTT) gene promoter polymorphism and autism are controversial" 05/01/2006 - "Serotonin transporter gene promoter polymorphism and autism: a family-based genetic association study in Japanese population." 01/01/2002 - "This could lead to inconsistent genetic association results, such as those of prior studies on serotonin transporter (5-HTT) gene promoter variants and autistic disorder" Get all the results and reference details, order at left...
684 Drugs and Important Bio-Agents and 1740 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Massage (Reflexology) 12/01/2005 - "In conclusion, giving massage to children with autism may help to enhance the emotional bond between parent and child." 12/01/2005 - "This exploratory study aimed to address two questions: (1) What does touch mean between parents and their children with autism on completion of a massage intervention" 12/01/2005 - "Exploring a massage intervention for parents and their children with autism: the implications for bonding and attachment." 10/01/2001 - "Twenty children with autism, ages 3 to 6 years, were randomly assigned to massage therapy and reading attention control groups" 10/01/2001 - "Brief report: improvements in the behavior of children with autism following massage therapy." Get all the results and reference details, order at left...
2.	Breathing Exercises (Qigong) 01/01/2005 - "A medical qigong methodology for early intervention in autism spectrum disorder: a case series." 09/01/2008 - "In 2005, a qigong massage intervention based on Chinese medicine and delivered by a doctor of Chinese medicine was shown to improve sensory impairment and adaptive behavior in a small controlled study of young children with autism" 01/01/2007 - "Improvement in sensory impairment and social interaction in young children with autism following treatment with an original Qigong massage methodology." 01/01/2007 - "The effectiveness of the Cignolini methodology, an original Qigong massage methodology, in treating sensory impairment in young children with autism was evaluated in a small, controlled study" 09/01/2008 - "Outcomes of a pilot training program in a qigong massage intervention for young children with autism." Get all the results and reference details, order at left...
3.	Drug Therapy (Chemotherapy) 09/01/1994 - "Antiserotonergic pharmacotherapy has been partially effective in treating a subgroup of children with autistic disorder" 05/01/1996 - "Results of recent studies in pharmacotherapy in autism are presented" 08/01/2007 - "The status of pharmacotherapy for autism spectrum disorders." 07/01/2007 - "The variable expression of autism over the lifespan is likely to lead to different symptoms and support requirements, and to distinct responses to pharmacotherapy treatment, in older patients compared to children" 08/01/2005 - "Autism spectrum disorders: emerging pharmacotherapy." Get all the results and reference details, order at left...
4.	Music Therapy 10/01/2008 - "It was a randomized controlled study employing a single subject comparison design in two different conditions, improvisational music therapy and play sessions with toys, and using standardized tools and DVD analysis of sessions to evaluate behavioral changes in children with autism" 10/01/2008 - "The purpose of this study was to investigate the effects of improvisational music therapy on joint attention behaviors in pre-school children with autism" 09/01/2007 - "OBJECTIVE: The aim of this study was to investigate whether a musical training program based on interactive music therapy sessions could enhance the behavioral profile and the musical skills of young adults affected by severe autism" 09/01/2007 - "CONCLUSIONS: Our pilot data seem to suggest that active music therapy sessions could be of aid in improving autistic symptoms, as well as personal musical skills in young adults with severe autism." 09/01/2007 - "METHODOLOGY: Young adults (N = 8) with severe (Childhood Autism Rating Scale >30) autism took part in a total of 52 weekly active music therapy sessions lasting 60 minutes" Get all the results and reference details, order at left...
5.	Aftercare (After-Treatment) 06/01/2001 - "After treatment, the patients showed significant improvement on the scores of the Yale--Brown Obsessive--Compulsive Scale -- Obsessions subscale and the Hamilton Anxiety Scale; Clinical Global Impressions -- Autism scores showed 3 of the patients much improved and 3 unchanged" 05/01/2006 - "METHODS: Patients were treated by "Jin's three-needling" as the main measure with the assistance of behavior intervention, and the changes were compared among the three groups (29 cases in combination group, 15 cases in acupuncture group and 10 cases in intervention group) before and after treatment of various factors and scores estimated by the autism behavior checklist (ABC) and autism development checklist (ADC)" 12/09/1999 - "We used standardized behavioral measures of the primary and secondary features of autism, including the Autism Behavior Checklist, to assess the degree of impairment at base line and over the course of a four-week period after treatment" 01/01/1997 - "After treatment, children with autism engaged in increased levels of social behavior." 09/01/1991 - "Both measures showed that although the children with autism functioned at a lower level than their normally developing peers, the children with autism had narrowed this gap after treatment, making a nearly 19-point increase in IQ and an 8-point gain in language quotient" Get all the results and reference details, order at left...
47 Therapies and Procedures and 144 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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