GTP Pyrophosphokinase (Stringent Factor)

An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5.

Also Known As:

Stringent Factor; ATP Guanosine Phosphate Pyrophosphotransferase; Factor, Stringent; Pyrophosphokinase, GTP; Pyrophosphotransferase, ATP-Guanosine Phosphate; ATP-Guanosine Phosphate Pyrophosphotransferase; ATP:GTP 3'-pyrophosphotransferase

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Diphosphotransferases
        GTP Pyrophosphokinase: 8
        E coli relA protein

Experts

1.	Hauryliuk, Vasili: 2 articles (01/2019 - 01/2016)
2.	Ferrazzoli, Alexander E: 1 article (01/2022)
3.	Lovett, Susan T: 1 article (01/2022)
4.	Sass, Thalia H: 1 article (01/2022)
5.	Dzhygyr, Ievgen: 1 article (01/2019)
6.	Lindemose, Søren: 1 article (01/2019)
7.	Roghanian, Mohammad: 1 article (01/2019)
8.	Turnbull, Kathryn Jane: 1 article (01/2019)
9.	Abdelshahid, Maha: 1 article (01/2016)
10.	Arenz, Stefan: 1 article (01/2016)

Related Diseases

1.	Starvation 12/01/1988 - "Here we show that a mutation in relA, the structural gene for stringent factor, blocks intracellular proteolysis that is normally triggered by amino acid starvation. " 01/01/2007 - "Regulation of production of the translational apparatus via the stringent factor ppGpp in response to amino acid starvation is conserved in many bacteria. " 01/01/2019 - "Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp. " 09/01/2013 - "This process is initiated by the stringent factor RelA, which senses the presence of deacylated tRNA in the ribosome as a symptom of amino-acid starvation to synthesize the alarmone (p)ppGpp. " 01/01/2022 - "We also demonstrate that the RNA-polymerase associated factor, stringent starvation protein A, induced by the accumulation of ppGpp, also affects iraD expression, with a positive effect on constitutive expression and a negative effect on azidothymidine-induced expression."
2.	Polyploidy 06/01/1977 - "The relA gene product, ATP: GTP 3'-pyrophosphotransferase (stringent factor) has been isolated in homogeneous form from an Escherichia coli strain polyploid for this gene at a yield of 1 mg/100 g cells and at a specific activity in a ribosome-activated assay at 37 degrees C of 120 mumol guanosine pentaphosphate formed min-1 mg protein-1. "
3.	Infections 08/01/1976 - "Stringent factor is present among the gene products synthesized by lambdadpyrG relA after infection of ultraviolet-killed cells, as analyzed by polyacrylamide gel electrophoresis. "

Related Drugs and Biologics

1.	Guanosine Pentaphosphate
2.	Amino Acids
3.	Guanosine Tetraphosphate
4.	GTP Pyrophosphokinase (Stringent Factor)
5.	Zidovudine (Retrovir)
6.	Staphylococcal Protein A (Protein A)
7.	Transfer RNA (tRNA)
8.	DNA-Directed RNA Polymerases (RNA Polymerase)
9.	Nucleotides
10.	Guanosine Triphosphate (GTP)