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ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)

An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
Also Known As:
Citrate Synthase, ATP; ATP Citrate Lyase; ATP Citrate Synthase; ATP Citrate (pro-3S)-Lyase; ATP-Dependent Citrate Lyase; ATP Dependent Citrate Lyase; Citrate Lyase, ATP; Citrate Lyase, ATP-Dependent; Cleavage Enzyme, Citrate; Lyase, ATP Citrate; Lyase, ATP-Dependent Citrate; Synthase, ATP Citrate; Citrate Cleavage Enzyme; ATP:citrate oxaloacetate-lyase ((pro-S)-CH2COO(-)--acetyl-CoA) (ATP-dephosphorylating)
Networked: 219 relevant articles (6 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wellen, Kathryn E: 7 articles (12/2020 - 08/2014)
2. Pinkosky, Stephen L: 4 articles (01/2022 - 11/2016)
3. Carrer, Alessandro: 4 articles (01/2019 - 08/2014)
4. Zhao, Steven: 4 articles (01/2019 - 07/2017)
5. Migita, Toshiro: 4 articles (03/2016 - 10/2008)
6. Jiang, Lei: 3 articles (01/2022 - 04/2009)
7. Steinberg, Gregory R: 3 articles (01/2022 - 11/2016)
8. Van den Bossche, Jan: 3 articles (12/2021 - 12/2020)
9. Verberk, Sanne G S: 3 articles (12/2021 - 12/2020)
10. Lalwani, Narendra D: 3 articles (07/2021 - 11/2016)

Related Diseases

1. Inflammation (Inflammations)
2. Hypercholesterolemia
3. Hyperlipidemias (Hyperlipidemia)
4. Obesity
5. Fatty Liver

Related Drugs and Biologics

1. 8- hydroxy- 2,2,14,14- tetramethylpentadecanedioic acid
2. Lipids
3. Coenzyme A (CoA)
4. AMP-Activated Protein Kinases
5. Cholesterol
6. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7. Fructose
8. Leptin Receptors
9. Ellagic Acid
10. Lycopene

Related Therapies and Procedures

1. Therapeutics
2. Radiotherapy
3. Castration