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ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)

An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
Also Known As:
Citrate Synthase, ATP; ATP Citrate Lyase; ATP Citrate Synthase; ATP Citrate (pro-3S)-Lyase; ATP-Dependent Citrate Lyase; ATP Dependent Citrate Lyase; Citrate Lyase, ATP; Citrate Lyase, ATP-Dependent; Cleavage Enzyme, Citrate; Lyase, ATP Citrate; Lyase, ATP-Dependent Citrate; Synthase, ATP Citrate; Citrate Cleavage Enzyme; ATP:citrate oxaloacetate-lyase ((pro-S)-CH2COO(-)--acetyl-CoA) (ATP-dephosphorylating)
Networked: 83 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Islam, Mohammad Shyful: 3 articles (10/2015 - 06/2014)
2. Xiao, Dong: 3 articles (10/2015 - 06/2014)
3. Gao, Yajuan: 3 articles (10/2015 - 06/2014)
4. Seimiya, Hiroyuki: 3 articles (07/2014 - 10/2008)
5. Migita, Toshiro: 3 articles (07/2014 - 10/2008)
6. Schwartz, Laurent: 3 articles (02/2012 - 05/2010)
7. Jiang, Guoqin: 2 articles (10/2015 - 06/2014)
8. Zeng, Yan: 2 articles (10/2015 - 06/2014)
9. Tian, Jian: 2 articles (10/2015 - 06/2014)
10. Okabe, Sachiko: 2 articles (07/2014 - 05/2013)

Related Diseases

1. Fatty Liver
2. Hyperglycemia
3. Neoplasms (Cancer)
4. Prostatic Neoplasms (Prostate Cancer)
5. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)

Related Drugs and Biologics

1. Leptin Receptors
2. Citric Acid (Citrate)
3. Facilitative Glucose Transport Proteins (Glucose Transporter)
4. Fatty Acid Synthetase Complex (Fatty Acid Synthase)
5. Enzymes
6. Acetyl-CoA Carboxylase
7. Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)
8. hydroxycitric acid
9. Thyroxine (Levothyroxine)
10. Oxidoreductases