|1.||Hadjivassiliou, Marios: 21 articles (01/2015 - 03/2003)|
|2.||Hagerman, Paul J: 19 articles (11/2014 - 05/2003)|
|3.||Hagerman, Randi J: 17 articles (11/2014 - 11/2005)|
|4.||Tassone, Flora: 16 articles (05/2014 - 05/2003)|
|5.||Koenig, Michel: 14 articles (01/2015 - 09/2003)|
|6.||Pandolfo, Massimo: 13 articles (11/2015 - 03/2004)|
|7.||Klockgether, Thomas: 12 articles (11/2015 - 05/2004)|
|8.||Dar, M Saeed: 12 articles (08/2014 - 09/2002)|
|9.||Klockgether, T: 12 articles (04/2014 - 07/2000)|
|10.||Schöls, L: 12 articles (06/2013 - 08/2000)|
|1.||Acetazolamide (Diamox)FDA LinkGeneric
01/01/2012 - "Acetazolamide can be dramatic in controlling episodes of ataxia with EA2 but is typically less beneficial with EA1."
01/01/1998 - "Treatment is effective for many of these, and the treatment of the episodic ataxias with acetazolamide can sometimes have a dramatic effect. "
11/01/2012 - "Some patients with episodic ataxia type 1 (EA1) will also describe improvement with acetazolamide. "
01/01/1996 - "EEG studies were performed in six family members affected by acetazolamide-responsive paroxysmal ataxia. "
05/01/1988 - "A magnetic resonance imaging study was performed in three symptomatic members of two families with a diagnosis of acetazolamide-responsive familial paroxysmal ataxia. "
|2.||gabapentin (Neurontin)FDA LinkGeneric
03/15/2009 - "The total period of gabapentin treatment was 4 weeks, and outcome measures were determined with the International Cooperative Ataxia Rating Scales (ICARS) and postural sway studies. "
12/08/2009 - "Gabapentin treatment improves motor coordination in a mice model of progressive ataxia."
03/01/2007 - "Gabapentin, renally excreted, with a half-life of 6.5-10.5 h, may cause ataxia. "
10/01/2005 - "Side effects observed initially on addition of gabapentin included sedation and hind limb ataxia. "
08/01/2002 - "Previous reports of gabapentin overdose have described mild symptoms of somnolence, ataxia and slurred speech. "
|3.||Thiamine (Aneurin)FDA Link
05/01/2012 - "She was treated with parenteral thiamine and her visual loss reversed and her ataxia improved dramatically. "
03/01/1994 - "Thiamine produced a clinically impressive and statistically significant improvement in clinical severity grading in patients with the seasonal ataxia compared with placebo (MANOVA, df = 1, F = 35.087, p < 0.0001), with a significant time-treatment interaction (MANOVA, df = 3, F = 32.36, p < 0.0001). "
03/01/1994 - "A double-blind, placebo-controlled study of the efficacy of thiamine hydrochloride in a seasonal ataxia in Nigerians."
01/01/2011 - "However, thiamine potentiated both stretching and ataxia-induced behaviours. "
04/01/2007 - "Nutritional stabilization and parenteral thiamine replacement resulted in rapid improvement of her ataxia and nystagmus and contributed to her recovery. "
06/01/2005 - "Although mild cerebellar-like ataxia appeared on day 5, intravenous immunoglobulin (0.4 g/kg/day for four days) rapidly improved his neurological abnormalities. "
08/01/2006 - "Intravenous immunoglobulin treatment in painful sensory neuropathy without sensory ataxia associated with Sjögren's syndrome."
07/01/2005 - "Treatment with diazepam led to resolution of spasticity, whereas repeated courses of intravenous immunoglobulin improved cerebellar function, including appendicular ataxia and downbeating nystagmus. "
02/14/2006 - "The authors evaluated jejunal biopsy samples from nine patients with gluten ataxia and seven patients with other causes of ataxia for the presence of TG2-related immunoglobulin deposits using double-color immunofluorescence. "
05/01/2011 - "Ataxia worsened within a few days after onset and was not cured by steroids or intravenous immunoglobulin, delaying a definite diagnosis until a tumor was detected. "
|5.||Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
01/01/2008 - "To investigate safety and efficacy of botulinum A toxin external urethral sphincter injection in the treatment of patients with detrusor external sphincter dyssynergia (DSD) and neurogenic low detrusor contractility (DC). "
03/01/2014 - "[Botulinum A toxin and detrusor sphincter dyssynergia: retrospective study of 47 patients]."
09/01/2011 - "Botulinum toxin type A is used in treatment of bladder hyperactivity and sphincter dyssynergia and was reported to alleviate lower urinary tract symptoms in patients with BPH. "
08/01/2011 - "The first application of botulinum toxin type A (BoNT-A) in urology was its injection into the urinary sphincter to treat neurogenic detrusor-sphincter dyssynergia (DSD) in quadriplegic men. "
03/01/2008 - "Editorial comment on: Intraprostatic and bladder-neck injection of botulinum A toxin in treatment of males with bladder-neck dyssynergia: a pilot study."
|6.||Diazepam (Valium)FDA LinkGeneric
04/01/1997 - "Naive rats given diazepam (0.5, 3.0, 6.0 mg/kg, IP) displayed dose-related maze acquisition impairments and sensorimotor disturbances (swimming in the periphery of the pool, deflecting off or swimming over the hidden platform, jumping off the platform when placed there after a trial, ataxia on a narrow wooden beam). "
11/01/2013 - "When combined with diazepam, WYS8 caused a reduction in sedation, muscle relaxation, and anticonvulsant activity, as compared with this BZ alone, whereas ataxia was preserved, and the anxiolytic effect of 2 mg/kg diazepam was unmasked. "
01/15/2010 - "The significant potentiation of diazepam-induced ataxia and decreased motor activity by compounds 8a and 8c in the Hippocratic screen may be associated with alpha1 selectivity."
01/15/2010 - "However, they elicited significant effects in combination with diazepam on diazepam-induced activities such as decreased motor activity, ataxia and loss of righting reflex. "
11/01/2002 - "Motor coordination was not affected by BF per se, but diazepam-induced motor incoordination was potentiated. "
|7.||coenzyme Q10 (CoQ10)IBA
07/15/2010 - "However, the remarkable clinical response in 1 case without CoQ(10) deficiency highlights the importance of treatment trials for identification of patients with CoQ(10)-responsive ataxia."
01/01/2014 - "Coenzyme Q10 supplementation was initiated, improving ataxia and nystagmus. "
02/01/2012 - "The authors performed sequencing of known Coenzyme Q10 (CoQ10) deficiency genes in 22 patients with unexplained recessive or sporadic ataxia. "
07/15/2010 - "We performed an open-label prospective study: patients were evaluated clinically (international cooperative ataxia rating scale [ICARS] scale, MRI, and videotape registration) at baseline and every 6 months during a period of 2 years after CoQ(10) treatment (30 mg/kg/day). "
03/01/2008 - "Five additional mutations in ADCK3 were found in three patients with sporadic ataxia, including one known to have CoQ(10) deficiency in muscle. "
|8.||Vitamin EFDA LinkGeneric
08/01/1982 - "Treatment with vitamin E over a 2 1/2 year period appeared to arrest the progression of the neurological deficit and subsequent increase in dosage produced some improvement in her ataxia."
01/01/2015 - "We emphasize that all patients who develop ataxia in childhood should be routinely tested for AVED to make an early diagnosis for initiating treatment with high dose vitamin E to avoid severe neurological deficits."
07/01/2014 - "α-Tocopherol (αT) is the predominant form of vitamin E in tissues and its deficiency leads to ataxia in humans. "
01/01/2013 - "Few of these disorders are amenable to effective treatment, the most important of these being vitamin E-responsive ataxia. "
02/01/2009 - "Effect of vitamin E treatment on progressive cognitive impairment in a patient with adult-onset ataxia: a case report."
|9.||Amiodarone (Amiodarona)FDA LinkGeneric
03/15/2009 - "The ataxia lessened over the first two weeks after the amiodarone was discontinued and resolved completely within five months after drug discontinuation."
01/01/2013 - "In view of comprehensive routine negative work-up for ataxia, recent use of amiodarone and worsening of symptomatology with increase in its dosing, drug-induced neurotoxicity from amiodarone was suspected. "
03/15/2009 - "A 76-year-old man developed ataxia after taking amiodarone hydrochloride 400 mg orally three times daily for more than two months; the regimen was the intended loading dosage. "
05/01/2008 - "Ataxia caused by amiodarone in older people."
05/15/2006 - "Severe ataxia caused by amiodarone."
|10.||Prednisolone (Predate)FDA LinkGeneric
07/15/2007 - "However, emotional and behavioral disturbances relapsed and remitted associated with exacerbation of truncal ataxia and ocular flutter, which responded favorably to prednisolone. "
06/01/2004 - "All patients received prednisolone for the total duration of symptoms and there was complete resolution of ataxia in them all. "
05/15/2002 - "Neuronal degeneration and Lafora inclusion bodies predate the onset of impaired behavioral responses, ataxia, spontaneous myoclonic seizures and EEG epileptiform activity. "
07/01/1993 - "Two months later right hemiparesis and ataxia appeared that were alleviated by prednisolone. "
08/01/1998 - "Prednisolone improved her ataxia and was associated with cessation of both seizures and exercise induced dystonia. "
|1.||Psychology Biofeedback (Biofeedback)
04/01/2007 - "This investigation provides definitive support for the efficacy of biofeedback for pelvic floor dyssynergia and shows that instrumented biofeedback is essential to successful treatment."
07/01/2004 - "Good results-a response rate of up to 90%-demonstrates that biofeedback training is successful in the treatment of detrusor-sphincter dyscoordination. "
10/01/2001 - "The modified biofeedback program including appropriate explanations and psychological approaches appeared effective for treating 92% of children with detrusor-sphincter dyssynergia. "
06/01/2015 - "Efficacy of biofeedback plus transanal stimulation in the management of pelvic floor dyssynergia: a randomized trial."
05/01/2014 - "Biofeedback was found to be helpful for two children with detrusor-sphincter dyssynergia. "
07/01/2010 - "All patients showed significant improvement in bladder capacity (P <.01), maximal detrusor pressure (P <.01), and detrusor-sphincter dyssynergia (P <.01) after 3 and 6 months of receiving injections. "
06/01/2006 - "Sphincter injections are effective in the short-term treatment of neurogenic detrusor-sphincter dyssynergia (level 1c). "
07/01/2003 - "Both transurethral and transperineal injections monitored by EMG are equally effective in improving detrusor-sphincter dyssynergia. "
09/01/2010 - "Women with detrusor-sphincter dyssynergia received transperineal injections of lantox in the region of external urethral sphincter. "
11/01/2008 - "A total of 50 patients with spinal cord lesion and detrusor sphincter dyssynergia were treated with BoNT-A injections (200 U) into the urinary bladder detrusor muscle. "
06/01/1999 - "The UroLume stent is as effective as conventional external sphincterotomy for treating external detrusor-sphincter dyssynergia. "
05/01/1999 - "The UroLume stent demonstrates long-term safety and efficacy for the treatment of external detrusor-sphincter dyssynergia. "
11/01/1996 - "To evaluate the long-term efficacy of a permanently implanted urethral stent in the treatment of spinally injured patients with detrusor-sphincter dyssynergia. "
06/01/1996 - "Four spinal cord injured men with voiding symptoms of detrusor external sphincter dyssynergia as noted by complete urological evaluation, including a video urodynamic study, were treated with the self-expanding sphincter stent. "
04/01/2009 - "External urethral sphincter stent for dyssynergia."
06/01/2001 - "Analgesia of the tail, perineum, hind limbs, flank and thorax was mild to moderate in group I, but complete analgesia of tail, perineum and hind limbs was recorded in group II. Motor incoordination was mild in group I and severe in group II. Significant reduction in heart rate (more pronounced in group I) and respiratory rate (more pronounced in group II), and a significant increase in central venous pressure were recorded in both groups. "
07/01/2014 - "SPA produced pronounced analgesia, mild sedation and minimal ataxia. "
07/01/2014 - "In groups 1 and 3 analgesia, sedation and ataxia scores, cardiopulmonary and blood gas variables were recorded at different intervals before and after PSA. "
01/01/2014 - "Onset time and duration of caudal analgesia, sedation level and ataxia were recorded after drug administration. "
09/01/2012 - "Heart rate, blood pressure, respiratory rate, rectal temperature, intestinal motility, analgesia, behavior, and ataxia were determined before treatment (time 0; baseline); at 5, 10, 15, 30, 45, 60, 75, and 90 minutes; and every 30 minutes thereafter until the cessation of analgesia. "
07/01/1991 - "[Experimental and clinical studies of urethral anesthesia on etiology and treatment of detrusor-sphincter dyssynergia]."
01/01/2012 - "Horses with intracranial lesions and severe ataxia are not good anesthesia candidates; however, only one method to obtain cerebrospinal fluid (CSF) from the cervical region in a standing horse has been reported. "
07/01/1991 - "In clinical cases with detrusor-sphincter dyssynergia, urethral anesthesia produced detrusor-sphincter synergia or a decrease in the external urethral sphincter activities during micturition, and a decrease in the maximum urethral closure pressure and the residual volume. "
07/01/1991 - "In thoracic spinal cats with detrusor-sphincter dyssynergia, urethral anesthesia produced detrusor-sphincter synergia, an increase in the maximum bladder pressure and a decrease in the residual volume. "
01/01/1988 - "With higher exposures the toxic effects are more pronounced and can include intoxication, incoordination, exhilaration, sleepiness, stupor, and the beginning stages of anesthesia. "