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Asthma (Bronchial Asthma)

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Also Known As:
Bronchial Asthma; Asthmas; Asthma, Bronchial
Networked: 48265 relevant articles (3775 outcomes, 8195 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1. Rhinitis
2. Inflammation
3. Chronic Obstructive Pulmonary Disease (COPD)
4. Hypersensitivity (Allergy)
5. Asthma (Bronchial Asthma)

Experts

1. Barnes, Peter J: 126 articles (03/2014 - 01/2002)
2. Park, Choon-Sik: 121 articles (09/2014 - 06/2003)
3. Weiss, Scott T: 110 articles (10/2014 - 03/2002)
4. Szefler, Stanley J: 103 articles (09/2014 - 01/2002)
5. Busse, William W: 90 articles (09/2014 - 04/2002)
6. Postma, Dirkje S: 89 articles (07/2014 - 01/2002)
7. Park, Hae-Sim: 85 articles (09/2014 - 05/2002)
8. Holgate, Stephen T: 79 articles (07/2014 - 01/2002)
9. Boulet, Louis-Philippe: 79 articles (07/2014 - 08/2002)
10. Holgate, S T: 78 articles (09/2014 - 02/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asthma:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
08/01/2003 - "The significant findings of 17 selected, controlled clinical trials of oral corticosteroids (OCSs) for acute exacerbations of asthma in children, compared with placebo or with other formulations of corticosteroids, can be summarized as follows: 1) OCSs are effective for the outpatient treatment of acute asthma, 2) pulmonary function tests may not be the best means of assessing the efficacy of OCSs for acute asthma, 3) early administration of OCSs for acute asthma reduces hospitalizations, 4) the critical factor for a positive outcome is early administration of the corticosteroid, and 5) OCSs are preferred for the outpatient treatment of acute asthma. "
10/01/1998 - "This study aimed to determine whether the changes in practice in the management of asthma since the early 1980s have improved standards (as assessed by higher actual/best function) and reduced the need for oral corticosteroids. "
11/01/2014 - "Although inhaled corticosteroids and leukotriene modifiers are most effective in asthma they are still not always capable of appropriately controlling the disease. "
01/01/2014 - "Strategies with combined inhaled corticosteroids and long acting β agonists are most effective and safe in preventing severe exacerbations of asthma, although some heterogeneity was observed in this network meta-analysis of full text reports."
01/01/2014 - "Anti-inflammatory treatments are effective for most of asthma patients, but there are subjects whose disease is incompletely controlled by inhaled or systemic corticosteroids and these patients account for about 50% of the healthcare costs of asthma. "
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2. Budesonide (Pulmicort)FDA LinkGeneric
3. Albuterol (Salbutamol)FDA LinkGeneric
4. omalizumab (Xolair)FDA Link
5. montelukast (Singulair)FDA Link
6. fluticasone (Cutivate)FDA LinkGeneric
7. salmeterol (Serevent)FDA Link
8. formoterol (Oxis)FDA Link
9. Immunoglobulin E (IgE)IBA
03/01/1999 - "This study suggests that (1) the percentage of CD4+, CD8+, or IL-2R+ lymphocytes in peripheral blood was significantly elevated during acute attacks and returned to normal ranges after complete remission was achieved; (2) plasma soluble IL-2R is a sensitive marker for asthma activity; and (3) atopic asthmatic children seem to have a hereditary predisposition of having higher levels of soluble IL-2R in asthma attacks, coinherited with the trait of IgE."
01/01/2012 - "Blood immunoglobulin E levels were significantly increased in the asthma group, and blood eosinophils were significantly elevated in the complete asthma remission, symptomatic remission and asthma groups compared with controls. "
12/01/2006 - "Skin tests are considered the gold standard for detecting allergen-specific immunoglobulin E (IgE) in the clinical setting and are an important tool for diagnosing and managing allergic asthma. "
07/01/2000 - "I have three objectives: (1) review T cell differentiation leading to the Th1/Th2 paradigm; (2) evaluate the increased prevalence of atopy, including asthma, as a consequence of a Th2-dominated immune system; (3) relate the high prevalence of asthma in inner city United States black children to the relatively recent migration of their ancestors from tropical regions of Africa, where genetically biased Th2-dependent IgE responses may be important in protection against high burdens of parasitic worms."
09/01/2012 - "Wheezy infants with positive family history of asthma and those who had not been breast fed showed significant reduction in the mean values of tPTEF/tE and increased both eosinophilic percentage and total serum IgE. "
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10. Theophylline (Theon)FDA LinkGeneric

Therapies and Procedures

1. Immunotherapy
2. Nebulizers and Vaporizers (Inhaler)
3. Metered Dose Inhalers (Metered Dose Inhaler)
4. Drug Therapy (Chemotherapy)
5. Aftercare (After-Treatment)

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