Astatine

Astatine. A radioactive halogen with the atomic symbol At, and atomic number 85. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism because it emits ALPHA PARTICLES.

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lindegren, Sture: 4 articles (03/2016 - 09/2003)
2.	Bäck, Tom: 3 articles (03/2016 - 12/2009)
3.	Jensen, Holger: 3 articles (03/2016 - 12/2009)
4.	Albertsson, Per: 2 articles (03/2016 - 07/2015)
5.	Aneheim, Emma: 2 articles (03/2016 - 07/2015)
6.	Palm, Stig: 2 articles (03/2016 - 07/2015)
7.	Barbet, Jacques: 2 articles (10/2014 - 01/2006)
8.	Faivre-Chauvet, Alain: 2 articles (10/2014 - 01/2006)
9.	Knapp, W H: 2 articles (12/2013 - 07/2002)
10.	Boyd, Marie: 2 articles (09/2011 - 08/2008)

Related Diseases

1.	Neoplasms (Cancer) 07/14/2015 - "Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. " 09/01/2011 - "Increased radiotoxicity to targeted tumors might also be achieved by the use of the α-particle emitter [(211)At]astatine rather than (131)I as radiolabel. " 12/01/2009 - "A dose-dependent effect on GFR was found and at the time interval 8-30 weeks after the first administration of astatine, the absorbed doses causing a 50% decrease in GFR were 16.4 +/- 3.3 and 14.0 +/- 4.1 Gy (mean +/- SEM), tumor- and non-tumor-bearing animals, respectively. " 08/01/2008 - "Radiation damage to targeted tumors may also be enhanced by the use of the alpha-particle emitter [(211)At]astatine rather than (131)I as radiolabel. " 07/01/2023 - "[211At]astatine-based anti-CD22 radioimmunotherapy for B-cell malignancies."
2.	Glioma (Gliomas) 04/14/2020 - "Targeted alpha therapy using astatine (211At)-labeled phenylalanine: A preclinical study in glioma bearing mice."
3.	Thyroid Neoplasms (Thyroid Cancer) 12/01/2022 - "In 2022, memorial 80 years later, alpha emitter astatine (211At), an analogue for iodine, was successfully administered to a patient with refractory thyroid cancer in Japan as a phase-1 clinical trial (first-in-human). " 08/21/2022 - "Astatine (211At) is an alpha-emitter with a better treatment efficacy against differentiated thyroid cancer compared with iodine (131I), a conventional beta-emitter. "
4.	Cysts 02/01/1954 - "Alpha irradiation; effect of astatine on the anterior segment and on an epithelial cyst." 01/01/1952 - "Alpha irradiation; effect of astatine on the anterior segment and on an epithelial cyst."
5.	Neoplasm Micrometastasis 09/01/2003 - "Poly-L- and poly-D-lysine were evaluated as carriers of astatine and biotin for prospective use as effector molecules in pretargeted radioimmunotherapy of micrometastases. "

Related Drugs and Biologics

1.	Phenylalanine (L-Phenylalanine)
2.	Iodine
3.	Bismuth
4.	Monoclonal Antibodies
5.	sodium-iodide symporter (sodium iodide symporter)
6.	Immunoconjugates (Immunoconjugate)
7.	Tin
8.	Thorium
9.	Radium
10.	Radioisotopes (Radionuclides)

Related Therapies and Procedures

1.	Therapeutics
2.	Radioimmunotherapy