|1.||Walsh, Thomas J: 40 articles (05/2015 - 01/2002)|
|2.||Kontoyiannis, Dimitrios P: 40 articles (03/2015 - 07/2003)|
|3.||Verweij, Paul E: 35 articles (07/2015 - 01/2003)|
|4.||Herbrecht, Raoul: 33 articles (03/2015 - 03/2002)|
|5.||Marr, Kieren A: 31 articles (01/2015 - 04/2002)|
|6.||Maertens, Johan: 30 articles (10/2015 - 11/2002)|
|7.||Denning, David W: 29 articles (12/2015 - 03/2002)|
|8.||Patterson, Thomas F: 25 articles (10/2015 - 02/2002)|
|9.||Cornely, Oliver A: 22 articles (07/2015 - 04/2004)|
|10.||Stevens, David A: 22 articles (12/2014 - 07/2002)|
|1.||Amphotericin B (Amphotericin)FDA LinkGeneric
11/01/1996 - "Surgical intervention and concomitant use of amphotericin-B for a month resulted in complete remission of the aspergillosis. "
03/16/1985 - "In conjunction with high dose amphotericin-B therapy complete resolution of aspergillosis was achieved in two cases, paralleled by slow recovery of bone marrow function, whereas in the third case only a partial remission was possible together with transient amelioration of granulopoiesis. "
07/01/2015 - "Although amphotericin B-azole combination therapy has traditionally been questioned due to potential antagonistic interactions, it is often used successfully to treat refractory invasive aspergillosis. "
05/01/2005 - "In clinical trials it demonstrated superior efficacy in addition to a survival benefit when compared with the then current treatment standard, amphotericin B, for primary treatment of invasive aspergillosis. "
11/15/2005 - "This study highlights the limited efficacy of salvage antifungal therapy, including therapy with lipid formulations of amphotericin B, and demonstrates the importance of effective initial therapy in invasive aspergillosis."
|2.||voriconazole (Vfend)FDA LinkGeneric
03/01/2010 - "The patient showed remarkable improvement with voriconazole suggesting aspergillosis. "
02/01/2004 - "Voriconazole currently offers the best prospect for success and tolerance as a first-line treatment for aspergillosis. "
06/01/2005 - "According to a randomised trial, voriconazole has added a significantly improved therapeutic option for primary therapy of invasive aspergillosis. "
09/01/2008 - "Clinical application of voriconazole for the treatment of aspergillosis in birds appears to be promising, because this drug has a high effectiveness and wide tissue distribution, and long-term treatment did not cause clinical signs of adverse effects or organ damage in chickens."
10/01/2007 - "Invasive tracheal aspergillosis treated successfully with voriconazole: clinical report and review of the literature."
|3.||caspofungin (Cancidas)FDA Link
01/01/2007 - "We analyzed retrospectively the safety and efficacy of caspofungin-based combination therapy in 40 children and adolescents, most of them were being treated for a malignant disease, who developed invasive aspergillosis (IA) between November 2002 and November 2005. "
01/01/2007 - "Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients."
11/01/2005 - "Caspofungin, a new antifungal agent with proven efficacy against invasive aspergillosis, has ideal potential for aerosolization. "
08/01/2001 - "Caspofungin was effective in patients with invasive aspergillosis intolerant or refractory to standard therapies. "
01/01/2013 - "Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats."
|4.||Itraconazole (Sporanox)FDA LinkGeneric
06/01/2006 - "Because detection rate of the fungus is very low, itraconazole in combination with surgical excision of focus is the best treatment of lung and brain invasive aspergillosis."
03/01/1994 - "The data indicate that itraconazole is highly effective in preventing true invasive aspergillosis. "
10/01/1999 - "The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults)."
12/01/1995 - "Serum concentrations of the drug ranged from 2 micrograms/mL to 30 micrograms/mL. Review of 20 cases of cerebral aspergillosis that were treated with itraconazole revealed that three of the four patients who received high doses (800 mg/d in the adults) of the drug responded favorably, while only two of the 16 patients who received a dose of 400 mg/d were cured. "
10/15/2001 - "Overall iv/oral itraconazole was safe and effective in invasive aspergillosis."
|5.||liposomal amphotericin BFDA Link
07/01/2005 - "Abelcet proved to be efficacious, but not curative, in the treatment of CNS aspergillosis and was equivalent overall to conventional AmB. "
12/01/2007 - "Standard dosing regimen of liposomal amphotericin B is as effective as a high-loading dose for patients with invasive aspergillosis: AmBiLoad trial."
12/01/2003 - "Efficacy of high doses of liposomal amphotericin B in the treatment of experimental aspergillosis."
12/01/1989 - "Liposomal amphotericin-B in the control of experimental aspergillosis in mice: Part I--Relative therapeutic efficacy of free and liposomal amphotericin-B."
08/01/2006 - "Efficacy of Abelcet alone, or in combination therapy, against experimental central nervous system aspergillosis."
12/01/2013 - "Screening with serum galactomannan might be associated with better outcome than symptom-triggered galactomannan testing in allogeneic HSCT recipients with invasive aspergillosis."
01/01/2015 - "The Platelia Aspergillus Ag assay (Bio-Rad) is designed for detecting Aspergillus galactomannan (GM) and is widely used for diagnosing invasive aspergillosis but is hampered by variable occurrences of unreproducible positive results. "
02/01/2014 - "Nowadays, the galactomannan (GM) assay has been widely used as an indication of invasive aspergillosis, even though the test is known to generate false-positive results. "
09/01/2003 - "Once accepted galactomannan test as a diagnostic criterium for invasive aspergillosis knowing potential causes of false positive results is of paramount importance."
07/01/2013 - "Diagnostic efficacy of Galactomannan (GM) assay for invasive aspergillosis (IA) is variably reported. "
06/01/2015 - "Novel methodologies, such as volatile organic compound detection and lateral flow devices, have recently been developed and promise noninvasive and rapid diagnosis of aspergillosis, while diagnostic algorithms that incorporate both GM and PCR have proven to be effective in early randomized trials as screening methods and can reduce the use of antifungal agents. "
09/01/2005 - "Several important obstacles underlie the correlation of in vitro susceptibility testing with in vivo efficacy of individual antifungal agents in the treatment of invasive aspergillosis. "
05/01/2013 - "This immune-competent patient showed multiple enhancing CNS aspergillosis in the cerebral hemisphere, which had a good outcome with antifungal agents. "
02/01/2012 - "Over the last decade, advances in diagnostic systems and the introduction of new antifungal agents have significantly improved outcomes in immunocompromised patients who develop invasive aspergillosis. "
12/01/2001 - "Because of its much larger dynamic range, the qPCR assay is superior to traditional CFU determination for monitoring the progression of disseminated aspergillosis and evaluating the activity of antifungal antibiotics against A. "
|8.||Fluconazole (Zonal)FDA LinkGeneric
06/01/1997 - "Treatment with fluconazole was effective in this case of semi-invasive aspergillosis."
09/01/1991 - "The efficacy of fluconazole against Aspergillus fumigatus was assessed in an immunosuppressed temporarily leukopenic rabbit model of invasive aspergillosis. "
03/01/1990 - "The efficacy of fluconazole against Aspergillus fumigatus was evaluated in an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. "
03/01/1990 - "Efficacy of fluconazole in experimental invasive aspergillosis."
01/01/2011 - "Despite her compliance with fluconazole fungal prophylaxis, computed tomography imaging revealed disseminated aspergillosis involving her lungs, liver, and kidneys. "
08/01/2005 - "The Aspergillus antigens reported here may have value both in diagnostic tests for different forms of aspergillosis and as vaccine candidates for protection against invasive disease."
02/01/1997 - "To compare the efficacy of active epidemiologic surveillance for invasive aspergillosis using Aspergillus cultures with the efficacy of surveillance using Aspergillus antigen detection. "
01/01/1992 - "It also showed that care should be taken in interpreting positive precipitin results from concentrated serum and that using several rather than one A fumigatus antigen extract is helpful for identifying allergic aspergillosis."
01/01/2013 - "Several studies in mouse model of invasive aspergillosis (IA) and in healthy donors have shown that different Aspergillus antigens may stimulate different adaptive immune responses. "
04/01/2012 - "The aim of this study was to develop and characterize antigens for the diagnosis of aspergillosis. "
|10.||micafungin (FK463)FDA Link
11/01/2006 - "This study evaluated the safety and efficacy of micafungin in patients with proven or probable invasive aspergillosis (IA). "
04/01/2003 - "We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. "
04/01/2003 - "Efficacy of micafungin alone or in combination against systemic murine aspergillosis."
01/01/2015 - "The objective of this study was to evaluate the efficacy and safety of micafungin as salvage monotherapy in patients with invasive aspergillosis. "
01/01/2015 - "Randomised, multicentre trial of micafungin vs. an institutional standard regimen for salvage treatment of invasive aspergillosis."
11/01/2006 - "These studies provide an important precursor to studies of the efficacy of inhaled ABLC as a prophylaxis of invasive aspergillosis after lung transplant."
10/23/2008 - "This study suggests an association between the donor TLR4 haplotype S4 and the risk of invasive aspergillosis among recipients of hematopoietic-cell transplants from unrelated donors."
10/23/2008 - "In the validation study, donor haplotype S4 also increased the risk of invasive aspergillosis (adjusted odds ratio, 2.49; 95% CI, 1.15 to 5.41; P=0.02); the association was present in unrelated recipients of hematopoietic-cell transplants (odds ratio, 5.00; 95% CI, 1.04 to 24.01; P=0.04) but not in related recipients (odds ratio, 2.29; 95% CI, 0.93 to 5.68; P=0.07). "
07/01/2005 - "To facilitate the design of strategies for prevention of invasive aspergillosis in solid-organ transplant recipients, this study investigates whether the development of early-onset and late-onset aspergillosis are related to different risk factors, thereby distinguishing 2 risk populations for this serious complication. "
12/15/2015 - "PTX3-Based Genetic Testing for Risk of Aspergillosis After Lung Transplant."
|2.||Transplantation (Transplant Recipients)
08/01/2002 - "Aspergillosis in liver transplant recipients: successful treatment and improved survival using a multistep approach."
10/01/2005 - "Our work confirms previous reports suggesting that non-myeloablative HSCT is effective in patients not eligible for conventional transplantation because of invasive aspergillosis."
04/01/2014 - "We analyzed invasive aspergillosis cases in a cohort of kidney transplant recipients and suggest that prognosis is improved with early diagnosis and treatment. "
07/01/2013 - "The study population consisted of 64 consecutive lung transplant recipients with proven or probable invasive aspergillosis. "
09/01/2010 - "This study found the incidence rate of invasive aspergillosis as an uncommon complication of liver transplant recipient cases but associated with poor outcomes. "
|3.||Drug Therapy (Chemotherapy)
05/01/2008 - "Extradural aspergillosis does not need chemotherapy preloading, whereas intradural variant may have improved survival chances after preloading. "
01/01/1999 - "Though clinical and radiological findings indicated that the patient's symptoms had gone into remission, aspergillosis recurred 4 months after the cessation of antifungal chemotherapy, requiring that the patient undergo an operation. "
04/01/2014 - "In 7 (78%) of these 9 patients, invasive aspergillosis occurred during the first course of chemotherapy. "
04/01/2014 - "In 9 of the patients (8.9%; 95% confidence interval 4.2%-16.2%), invasive aspergillosis was diagnosed (3 proven and 6 probable cases) a median of 19 (range 11-34) days after initiation of chemotherapy. "
01/01/2014 - "The case demonstrates that it is possible to successfully control advanced intracranial aspergillosis with tissue-sparing surgery and adjuvant antifungal chemotherapy in immunocompetent individuals."
01/01/2015 - "Invasive aspergillosis remains associated with significant morbidity and mortality, necessitating new options for salvage therapy. "
03/01/2009 - "Capsofungin has already established itself as a valuable therapy for candidaemia and salvage therapy of invasive aspergillosis. "
01/01/2008 - "Salvage therapy for invasive aspergillosis."
10/01/2007 - "We discuss primary and salvage therapy of invasive aspergillosis with focus on cerebral involvement. "
06/01/2006 - "Combined treatment can be used in refractory aspergillosis as a salvage therapy. "
12/01/2003 - "Strategies such as combination antifungal therapy and immunotherapy often are used as first-line treatment approaches in patients with documented invasive aspergillosis despite a paucity of clinical trial data. "
02/01/2012 - "Immunotherapy of aspergillosis."
10/01/2013 - "Robust T cell responses to aspergillosis in chronic granulomatous disease: implications for immunotherapy."
01/01/2013 - "Immunotherapy in invasive fungal infection--focus on invasive aspergillosis."
10/01/2013 - "Chronic granulomatous disease (CGD) patients are highly susceptible to invasive aspergillosis and might benefit from aspergillus-specific T cell immunotherapy, which has shown promise in treating those with known T cell defects such as haematopoietic stem cell transplant (HSCT) recipients. "