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Aspartate Carbamoyltransferase

An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
Also Known As:
Co(II)-Aspartate Transcarbamoylase; Ni(II)-Aspartate Transcarbamoylase; Carbamoyltransferase, Aspartate; Transcarbamylase, Aspartate; Aspartate Transcarbamylase; Carbamoyl-phosphate:L-aspartate carbamoyltransferase
Networked: 29 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Agron, Shani: 1 article (11/2015)
2. Dimmock, David: 1 article (11/2015)
3. Yizhak, Keren: 1 article (11/2015)
4. Brandis, Alexander: 1 article (11/2015)
5. Adler, Lital: 1 article (11/2015)
6. Korman, Stanley: 1 article (11/2015)
7. Itzkovitz, Shalev: 1 article (11/2015)
8. Silberman, Alon: 1 article (11/2015)
9. Erez, Ayelet: 1 article (11/2015)
10. Nagamani, Sandesh C S: 1 article (11/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Starvation
07/01/1988 - "To learn more about the relationship of this pathway to cellular proliferation, we have studied changes in levels of CAD RNA, rates of CAD protein synthesis, and levels of aspartate transcarbamylase activity in Syrian hamster ts13 cells in response to serum starvation and serum stimulation. "
08/01/1970 - "The synthesis of CPS(pyr) and aspartate transcarbamylase (ATC), the initial enzymatic steps of the pyrimidine pathway, are co-derepressed by pyrimidine starvation. "
06/01/1993 - "This conclusion was based on the findings that (i) the strains grew 10 to 15% more slowly in pyrimidine-free medium than in medium containing uracil; (ii) their levels of aspartate transcarbamylase were highly derepressed, as is characteristic for pyrimidine starvation conditions; and (iii) their levels of orotate phosphoribosyltransferase were low. "
02/01/1985 - "The mutant exhibited many of the predicted consequences of a decreased PRPP pool and a defective PRPP synthetase enzyme, including: poor growth on purine bases; decreased accumulation of 5-aminoimidazole ribonucleotide (the substrate of the blocked purE reaction) under conditions of purine starvation; excretion of anthranilic acid when grown in medium lacking tryptophan; increased resistance to inhibition by 5-fluorouracil; derepressed levels of aspartate transcarbamylase and orotate phosphoribosyltransferase, enzymes involved in the pyrimidine de novo biosynthetic pathway; growth stimulation by PRPP-sparing compounds (e.g. "
3. Hepatocellular Carcinoma (Hepatoma)
4. Melanoma (Melanoma, Malignant)
5. Ascites

Related Drugs and Biologics

1. pyrimidine
2. Carbamyl Phosphate (Carbamoyl Phosphate)
3. NSC 224131 (PALA)
4. Ligases
5. Dihydroorotase
6. Uridine Triphosphate (UTP)
7. Uridine Kinase
8. Orotate Phosphoribosyltransferase
9. DNA (Deoxyribonucleic Acid)
10. Aspartic Acid (Aspartate)