|1.||Kilberg, Michael S: 6 articles (11/2015 - 10/2006)|
|2.||Weinstein, John N: 5 articles (06/2014 - 04/2006)|
|3.||Lorenzi, Philip L: 5 articles (06/2014 - 11/2006)|
|4.||Richards, Nigel G J: 4 articles (10/2012 - 08/2005)|
|5.||Kitoh, Toshiyuki: 3 articles (10/2012 - 05/2003)|
|6.||den Boer, Monique L: 3 articles (07/2009 - 06/2005)|
|7.||Reinhold, William C: 3 articles (10/2008 - 04/2006)|
|8.||Pan, Yuan-Xiang: 3 articles (04/2008 - 12/2006)|
|9.||Godfrin, Yann: 2 articles (10/2015 - 08/2012)|
|10.||Gay, Fabien: 2 articles (10/2015 - 08/2012)|
|1.||Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
07/01/2008 - "[Study of the correlation between the expression level of asparagine synthetase and the outcome of children with acute lymphocytic leukemia]."
08/01/2006 - "To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia (ALL). "
02/01/2014 - "Asparagine synthetase (ASNS) gene polymorphism is associated with the outcome of childhood acute lymphoblastic leukemia by affecting early response to treatment."
10/01/2012 - "ASNase sensitivity has been shown to correlate with the asparagine synthetase (ASNS) protein content in acute lymphoblastic leukemia cell lines. "
07/01/2008 - "To determine whether the high level of asparagine synthetase (AS) expression in childhood acute lymphocytic leukemia (ALL) is associated with an inferior prognosis. "
03/01/2013 - "These results suggest that the asparagine synthetase gene can be a good marker for sugar starvation and that CsSEF1 might be involved in the signal transduction pathway from photoassimilate limitation to growth cessation in cucumber fruit."
12/01/1991 - "Regulation of asparagine synthetase gene expression by amino acid starvation."
10/01/1990 - "The decline of asparagine synthetase activity closely paralleled the expression of various maturation markers, but could also be induced by serum starvation. "
08/01/2012 - "In this study, our aim was to test whether asparagine synthetase (ASNS) deficiency in pancreatic malignant cells can lead to sensitivity to asparagine starvation. "
10/01/2011 - "Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C products) family transcriptional regulators, widespread among bacteria and archaea, is also known as feast/famine regulatory protein (FFRPs). "
04/01/2011 - "This study investigated the intracellular localization of asparagine synthetase (ASNS) in the relation with chemoresistance in leukemia. "
12/01/2006 - "Drug resistance in lymphoblastic and myeloblastic leukemia cells is poorly understood, with several lines of evidence suggesting that resistance can be correlated with upregulation of human asparagine synthetase (hASNS) expression, although this hypothesis is controversial. "
10/01/1990 - "Decrease in asparagine synthetase activity during cell differentiation of mouse and human leukemia cell lines."
06/01/1987 - "In contrast, in the relapsed patient with recurrent leukemia, the gene for asparagine synthetase may be derepressed and the leukemia would be ASNase-insensitive. "
06/01/1987 - "It is speculated that in the initial leukemia cell population (as encountered in refractory AML), the gene for asparagine synthetase is repressed and hence, the leukemia is sensitive to ASNase. "
06/05/2014 - "Unlike wild-type L-ASP, Q59L is inactive against cancer cells that express measurable asparagine synthetase (ASNS). "
04/15/2013 - "Asparagine synthetase: regulation by cell stress and involvement in tumor biology."
08/01/2014 - "Previous studies demonstrated that the elevated expression of asparagine synthetase (ASNS) is correlated with the resistance to L-Asp or PEG-Asp and may also affect the prognosis in some types of tumors, but the expression level and clinical significance of ASNS in NK/T cell lymphoma remain unknown. "
10/01/2015 - "Asparagine synthetase expression was evaluated using immunohistochemistry in resected PAC (471 patients) and in pairs of primary tumor and metastases (55 patients). "
11/01/2014 - "Asparagine synthetase (ASNS) is deemed to be a promising therapeutic target for the treatment of several cancers, but its functional role in human breast cancer is still unknown. "
|5.||Ovarian Neoplasms (Ovarian Cancer)
01/01/2009 - "Asparagine synthetase: a new potential biomarker in ovarian cancer."
01/01/2001 - "Microarray transcript expression studies of the 60 cell lines reveal, for example, a gene-drug correlation with potential clinical implications--that between the asparagine synthetase gene and the enzyme-drug L-asparaginase in ovarian cancer cells."
10/01/2008 - "Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines."
11/01/2006 - "Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells."
04/01/2006 - "When we examined the correlation between DNA copy number for all 353 unique loci on the bacterial artificial chromosome microarray and drug sensitivity for 118 drugs with putatively known mechanisms of action, we found a striking negative correlation (-0.983; 95% bootstrap confidence interval, -0.999 to -0.899) between activity of the enzyme drug L-asparaginase and DNA copy number of genes near asparagine synthetase in the ovarian cancer cells. "
|7.||Messenger RNA (mRNA)
|8.||DNA (Deoxyribonucleic Acid)
|9.||Leucine-Responsive Regulatory Protein
|10.||Transcription Factors (Transcription Factor)
|1.||Drug Therapy (Chemotherapy)