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Asialoglycoproteins

Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Also Known As:
Desialylated Glycoproteins; Glycoproteins, Desialylated
Networked: 27 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Schwientek, Tilo: 1 article (02/2009)
2. Teitz, Sebastian: 1 article (02/2009)
3. Müller, Stefan: 1 article (02/2009)
4. Hanisch, Franz-Georg: 1 article (02/2009)
5. Chung, Tai Wha: 1 article (01/2006)
6. Kang, Ji Hyun: 1 article (01/2006)
7. Kim, Jae Wha: 1 article (01/2006)
8. Yoon, Do Young: 1 article (01/2006)
9. Song, Eun Young: 1 article (01/2006)
10. Lee, Hee Gu: 1 article (01/2006)

Related Diseases

1. Hepatocellular Carcinoma (Hepatoma)
2. Liver Diseases (Liver Disease)
3. Fibrosis (Cirrhosis)
4. Neoplasms (Cancer)
5. Liver Cirrhosis (Hepatic Cirrhosis)

Related Drugs and Biologics

1. polymeric IgA
2. Asialoglycoprotein Receptor
3. Glycoproteins (Glycoprotein)
4. Corrinoids
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Trypsin
7. Transcobalamins (Transcobalamin II)
8. Orosomucoid (Seromucoid)
9. Oligosaccharides
10. Mercaptoethanol (2 Mercaptoethanol)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)