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Arthus Reaction

A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.
Also Known As:
Phenomenon, Arthus; Reaction, Arthus; Arthus Phenomenon
Networked: 424 relevant articles (7 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation (Inflammations)
2. Edema (Dropsy)
3. Vasculitis (Vasculitides)
4. Arthus Reaction
5. Delayed Hypersensitivity (Hypersensitivity, Type IV)

Experts

1. Sato, Shinichi: 11 articles (02/2021 - 03/2002)
2. Yanaba, Koichi: 10 articles (02/2021 - 03/2002)
3. Takehara, Kazuhiko: 7 articles (09/2012 - 03/2002)
4. Hasegawa, Minoru: 5 articles (09/2012 - 03/2002)
5. Ogawa, Fumihide: 4 articles (04/2013 - 05/2007)
6. Fujimoto, Manabu: 4 articles (09/2012 - 05/2007)
7. Schmidt, Reinhold E: 3 articles (02/2018 - 03/2005)
8. Singh, Ram Sarup: 3 articles (08/2017 - 09/2011)
9. Shimizu, Kazuhiro: 3 articles (04/2013 - 06/2009)
10. Matsushita, Takashi: 3 articles (09/2012 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arthus Reaction:
1. Antigen-Antibody Complex (Immune Complex)IBA
2. zileuton (Zyflo)FDA Link
3. A 78773IBA
4. Arachidonic Acid (Vitamin F)IBA
5. EndotoxinsIBA
6. SaltsIBA
7. InterleukinsIBA
8. Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
9. Ophthalmic Solutions (Eye Drops)IBA
10. MagnesiumIBA

Therapies and Procedures

1. Intravitreal Injections
2. Intravenous Administration
08/01/1969 - "This conclusion was supported by the more recent detection of a split product of C'4. Intravenous administration of the C'4 inactivator could prevent lethal Forssman shock and suppress the Arthus reaction in guinea pigs; it prolonged significantly the rejection time of renal xenografts but had no detectable effect on passive cutaneous anaphylaxis. "
12/01/1992 - "In the present study we examined the effects of NPC 15669 in the reversed passive Arthus reaction, an inflammatory reaction occurring in the skin of rats in response to intracutaneous injection of antigen followed by intravenous administration of antibody. "
09/01/2012 - "IgE-mediated cutaneous reverse passive Arthus reaction was induced in wild-type C57BL/6 or WBB6F1-+/+ mice and mast-cell-deficient WBB6F1-W/W(v) mice by intradermal injection of IgE anti-trinitrophenyl antibodies followed immediately by intravenous administration of trinitrophenyl bovine serum albumin. "
01/01/2002 - "Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration."
06/01/2009 - "In the current study, we established a mouse model of cutaneous eosinophilic vasculitis by the cutaneous reverse passive Arthus reaction using IgE injection instead of IgG. Wild-type C57BL/6 mice were injected with IgE anti-trinitrophenyl antibodies, followed immediately by intravenous administration of trinitrophenyl bovine serum albumin. "
3. Intravenous Injections
4. Oral Administration
5. Aftercare (After-Treatment)