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Neurogenic Arthropathy

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Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)

Also Known As:

Arthropathy, Neurogenic; Arthropathies, Neurogenic; Charcot Joint; Charcots Joint; Joint, Charcot's; Neurogenic Arthropathies; Charcot's Joint

Networked: 30 relevant articles (3 outcomes, 1 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 89
- Joint Diseases: 1553
  - Neurogenic Arthropathy: 30

Related Diseases

1.	Congenital Abnormalities (Deformity)
2.	Pain (Aches)
3.	Hereditary Sensory and Autonomic Neuropathies (HSAN)
4.	Ataxia (Dyssynergia)
5.	Infection

Experts

1.	Yoon, Kyoung Ho: 1 article (12/2009)
2.	Song, Sang Jun: 1 article (12/2009)
3.	Noh, Jung Ho: 1 article (12/2009)
4.	Bae, Dae Kyung: 1 article (12/2009)
5.	Mostafa, K M: 1 article (10/2009)
6.	El-Gafary, K A M: 1 article (10/2009)
7.	Al-Adly, W Y: 1 article (10/2009)
8.	Judge, Molly S: 1 article (01/2008)
9.	Uccioli, Luigi: 1 article (09/2006)
10.	Giurato, Laura: 1 article (09/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurogenic Arthropathy:

1.	CMF regimenIBA 11/01/1998 - "Thus the results of this expanded pilot study demonstrate the efficacy of CMF in accelerating the consolidation process of acute, phase 1, Charcot joint, and decreasing the amount of residual deformity." Order ALL the reference details at left...
2.	pamidronate (APD)FDA LinkGeneric 08/01/1999 - "Healing of Charcot's joint by pamidronate infusion." 08/01/1999 - "We describe the efficacy of pamidronate in treating a patient with Charcot's joint, due to hereditary sensory neuropathy, that caused loss of pain sensation. " Order ALL the reference details at left...
3.	C-Reactive ProteinIBA 01/01/2008 - "METHODS: In this study, C-reactive protein concentration was measured in seven patients with clinical features suggestive of an active Charcot joint. " Order ALL the reference details at left...
4.	Penicillins (Penicillin)FDA Link 11/01/1948 - "Charcot's joint with secondary purulent arthritis treated with intra-arterial penicillin." 11/01/1948 - "CHARCOT'S JOINT WITH SECONDARY PURULENT ARTHRITIS TREATED WITH INTRA-ARTERIAL PENICILLIN." Order ALL the reference details at left...
5.	Vincristine (Oncovin)FDA LinkGeneric 10/01/2000 - "Vincristine-induced neuroarthropathy (Charcot's joint)" Order ALL the reference details at left...
6.	SulfurIBA 02/01/1998 - "Marrow versus infection in the Charcot joint: indium-111 leukocyte and technetium-99m sulfur colloid scintigraphy." Order ALL the reference details at left...
7.	Hydrocortisone (Cortisol)FDA LinkGeneric 04/01/1963 - "[The pathogenesis of pseudo-Charcot joint after intra-articular instillation of hydrocortisone in rheumatoid arthritis.]" Order ALL the reference details at left...
8.	GalliumIBA 11/01/1981 - "Marked gallium accumulation in neurogenic arthropathy." Order ALL the reference details at left...
9.	Colloids (Colloid)IBA 02/01/1998 - "Marrow versus infection in the Charcot joint: indium-111 leukocyte and technetium-99m sulfur colloid scintigraphy." Order ALL the reference details at left...
10.	CoalIBA 01/01/1994 - "A Charcot joint developed following a spinal cord injury in a patient who had sustained a fracture-dislocation of the 12th thoracic vertebra and a spinal cord injury in a cave-in accident in a coal mine 40 years previously, and had since been assisted in walking with the aid of a short leg brace and a cane. " Order ALL the reference details at left...

Therapies and Procedures

1.	Arthroplasty 12/01/2009 - "The clinical results of total knee arthroplasty were satisfactory in most cases of Charcot joint. " 11/01/2003 - "The clinical and radiographic results of 40 modern design condylar total knee arthroplasties (TKAs) in 29 patients with a confirmed diagnosis of Charcot joint were reviewed. " 03/01/1998 - "Charcot's joint following Keller arthroplasty. " 08/01/1995 - "A painless and progressively growing mass consisting of fibronecrotic quadriceps femoris muscles with a giant multilobular cystic cavity formed 15 years after total knee arthroplasty for Charcot joint. " 08/01/1995 - "A giant thigh mass in a patient with total knee arthroplasty for Charcot joint." Order ALL the reference details at left...
2.	Transplants (Transplant) 06/01/1993 - "Total knee arthroplasty appears to be useful for the treatment of Charcot's joint with no ataxia at Eichenholtz' stage of coalescence and reconstruction if (1) proper surgical techniques to establish good ligamentous balancing and bony alignment by releasing ligaments are employed; (2) an adequate amount of bone is resected and remaining bony defects are reinforced with bone graft; (3) long-stem components are used on both the femoral and tibial sides." Order ALL the reference details at left...
3.	Arthrodesis 10/01/2009 - "The management of Charcot joint disease affecting the ankle and foot by arthrodesis controlled by an Ilizarov frame: early results." 03/01/1980 - "Technical difficulties achieving arthrodesis in a Charcot joint suggest that repeated needle aspirations are the preferred method of initial joint drainage. " 07/01/1950 - "Arthrodesis of the adult knee: with special reference to Charcot's joint." 03/01/1998 - "The indication for the arthrodesis was an infection in thirty-one knees and a Charcot joint in two. " 12/01/1989 - "The main clinical and typical X-ray findings as well as the radiologic features of different joints were described: (1) In Charcot joint of the shoulder, the entire scapula bone may be disintegrated; (2) After cleaning and arthrodesis, fragmentation of bone may reappear at both ends of the affected long bone and even the lateral surface of diaphysis; (3) Fragmentation of articular surface and subchondral bone may be seen in non-weight bearing surface; (4) 32 cases in our series had spontaneous fractures without history of trauma or undue strain; (5) Follow-up observation in short period (two to six weeks) showed rapid progressive destruction. " Order ALL the reference details at left...
4.	Amputation 09/01/2006 - "Both osteomyelitis and Charcot joint are conditions with an increased risk of lower limb amputation, both may have a successful outcome when recognized and treated in the early stages. " 01/01/2002 - "Diabetic foot disease in the form of ulceration, charcot joint fracture, and amputation affects 20% of patients with diabetes. " 01/01/1994 - "Below-knee amputation for Charcot joint developing 40 years after spinal cord injury. " 09/01/1986 - "A case of a variant of congenital indifference to pain, in which the patient initially developed lower extremity neurogenic arthropathy ultimately requiring bilateral above-the-knee amputations, is presented. " 10/01/1991 - "We report the case of a pseudoaneurysm of the dorsalis pedis artery after a Lisfranc amputation in an individual with diabetes mellitus, Charcot joint changes in the left forefoot, and atherosclerosis of the distal vessels." Order ALL the reference details at left...
5.	Prostheses and Implants (Prosthesis) 12/01/2009 - "Rotating hinge prostheses are strongly recommended for use in Charcot joint. " Order ALL the reference details at left...

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