Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)

Rheumatoid arthritis of children occurring in three major subtypes defined by the symptoms present during the first six months following onset: systemic-onset (Still's Disease, Juvenile-Onset), polyarticular-onset, and pauciarticular-onset. Adult-onset cases of Still's disease (STILL'S DISEASE, ADULT-ONSET) are also known. Only one subtype of juvenile rheumatoid arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
Also Known As:
Juvenile Idiopathic Arthritis; Juvenile Chronic Arthritis; Arthritis, Juvenile Rheumatoid; Juvenile-Onset Still Disease; Juvenile-Onset Stills Disease; Still Disease, Juvenile-Onset; Arthritides, Juvenile Idiopathic; Chronic Arthritis, Juvenile; Idiopathic Arthritides, Juvenile; Idiopathic Arthritis, Juvenile; Juvenile Idiopathic Arthritides; Juvenile Onset Still Disease; Juvenile Onset Stills Disease; Juvenile-Onset Still's Disease; Rheumatoid Arthritis, Juvenile; Still Disease, Juvenile Onset; Still's Disease, Juvenile Onset; Stills Disease, Juvenile-Onset; Arthritis, Juvenile Chronic; Arthritis, Juvenile Idiopathic; Still's Disease, Juvenile-Onset
Networked: 2763 relevant articles (238 outcomes, 344 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Rheumatoid Arthritis
2. Uveitis
3. Arthritis (Polyarthritis)
4. Giant Lymph Node Hyperplasia (Castleman's Disease)
5. Systemic Lupus Erythematosus (Libman-Sacks Disease)


1. Martini, Alberto: 47 articles (01/2016 - 10/2002)
2. Ruperto, N: 37 articles (01/2010 - 07/2001)
3. Yokota, Shumpei: 34 articles (04/2015 - 09/2003)
4. Paediatric Rheumatology International Trials Organisation: 32 articles (09/2007 - 07/2001)
5. Wulffraat, Nico M: 29 articles (12/2015 - 02/2003)
6. Ruperto, Nicolino: 26 articles (01/2016 - 07/2004)
7. Mori, Masaaki: 26 articles (01/2015 - 01/2004)
8. Horneff, Gerd: 25 articles (12/2015 - 04/2004)
9. Imagawa, Tomoyuki: 25 articles (06/2014 - 01/2004)
10. Wedderburn, Lucy R: 24 articles (12/2015 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Juvenile Rheumatoid Arthritis:
1. TNFR-Fc fusion protein (etanercept)FDA Link
2. Methotrexate (Mexate)FDA LinkGeneric
01/01/2015 - "Children and young people (CYP) with juvenile idiopathic arthritis (JIA) are known to have impaired health-related quality of life (HRQoL), which is improved significantly for many by treatment with methotrexate (MTX). "
04/01/2009 - "An improved high-performance liquid chromatography method for quantification of methotrexate polyglutamates in red blood cells of children with juvenile idiopathic arthritis."
07/01/2000 - "The results demonstrated the following: (1) radiographic evidence of condylar degeneration was apparent in 63% of all patients with juvenile rheumatoid arthritis with pauciarticular patients showing less temporomandibular involvement than polyarticular patients; (2) polyarticular juvenile rheumatoid arthritis patients receiving methotrexate showed less severe temporomandibular joint involvement than the polyarticular patients not receiving methotrexate; (3) the craniofacial structure was affected to a greater extent in the polyarticular form of the disease; (4) the craniomandibular index scores were significantly greater in the polyarticular group; (5) vertical height asymmetry and chin deviation were noted in more than 50% of the patients; and (6) there was a correlation between the severity of condylar lesions and cephalometric findings (ie, mandibular retroposition, posterior rotation, smaller ramus and mandibular dimensions) and the onset and duration of the disease. "
07/01/2004 - "To compare the safety and efficacy of parenteral methotrexate (MTX) at an intermediate dosage (15 mg/m(2)/week) versus a higher dosage (30 mg/m(2)/week) in patients with polyarticular-course juvenile idiopathic arthritis (JIA) who failed to improve while receiving standard dosages of MTX (8-12.5 mg/m(2)/week). "
07/01/2000 - "In conclusion, under the conditions of this study, methotrexate therapy was effective in minimizing temporomandibular joint destruction and craniofacial dysmorphology in juvenile rheumatoid arthritis patients with the polyarticular form of the disease."
3. tocilizumabFDA Link
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
5. Interleukin-6 (Interleukin 6)IBA
6. Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
7. adalimumab (Humira)FDA Link
8. infliximab (Remicade)FDA Link
9. Interleukin-1 (Interleukin 1)IBA
10. Amyopathic dermatomyositisIBA

Therapies and Procedures

1. Injections
2. Arthroplasty
3. Biological Therapy
4. Drug Therapy (Chemotherapy)
5. Stem Cell Transplantation