Infectious Arthritis (Septic Arthritis)

Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.

Also Known As:

Septic Arthritis; Suppurative Arthritis; Arthritis, Infectious; Arthritides, Bacterial; Arthritis, Suppurative; Bacterial Arthritides; Bacterial Arthritis; Viral Arthritis; Arthritis, Bacterial; Arthritis, Septic; Arthritis, Viral

Networked: 2095 relevant articles (110 outcomes, 176 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteomyelitis
2.	Infections
3.	Inflammation (Inflammations)
4.	Endocarditis
5.	Abscess

Experts

1.	Jin, Tao: 16 articles (01/2022 - 05/2010)
2.	Ali, Abukar: 13 articles (01/2022 - 01/2015)
3.	Bishayi, Biswadev: 12 articles (12/2021 - 08/2011)
4.	Josefsson, Elisabet: 12 articles (10/2015 - 02/2004)
5.	Mohammad, Majd: 11 articles (01/2022 - 01/2015)
6.	Pullerits, Rille: 9 articles (01/2022 - 08/2011)
7.	Na, Manli: 9 articles (11/2020 - 01/2015)
8.	Tarkowski, Andrej: 9 articles (05/2010 - 02/2004)
9.	Tarkowski, Andrzej: 9 articles (11/2007 - 03/2002)
10.	Jarneborn, Anders: 8 articles (01/2022 - 10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infectious Arthritis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 11/15/2023 - "Moreover, the excellent tissue penetration of ultrasound irradiation enables the local release of CO/H2 S in the joints of septic arthritis rats, exhibiting superior therapeutic efficacy without the need for any antibiotics." 02/01/2016 - "The overall survival is good with both surgical options, and even calves with liver involvement and septic arthritis associated can be successfully treated with a combination of long term antibiotics and umbilical vein marsupialization." 01/01/1983 - "In septic arthritis, systemic treatment with the appropriate antibiotic, following bacterial culture and sensitivity testing, can produce good results if prompt diagnosis is made." 11/18/2018 - "Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. " 12/01/2015 - "Arthroscopic drainage combined with antibiotic treatment is a simple and effective treatment for childhood septic arthritis of the knee and is for our reference attitude. "
2.	Vancomycin FDA LinkGeneric 06/01/2022 - "The results of the present study show that graft soaking in vancomycin (1 mg/ml) is effective for the prevention of septic arthritis after ACL reconstruction. " 06/01/2022 - "The aim of the present study was to evaluate if the vancomycin (1 mg/ml) is effective for the prevention of septic arthritis after ACL reconstruction. " 04/01/2020 - "Within the limitation confines of this study, intra-operative graft-soaking in vancomycin appears to be a safe and effective method to reduce the incidence of septic arthritis following ACLR. " 02/01/2022 - "Presoaking ACL Grafts in Vancomycin Decreases the Frequency of Postoperative Septic Arthritis: A Cohort Study of 29,659 Patients, Systematic Review, and Meta-analysis From the SANTI Study Group." 09/01/2019 - "Presoaking of hamstring autografts in vancomycin for primary ACL reconstruction prevented the occurrence of postoperative septic arthritis during the study period as compared with no soaking of the grafts."
3.	CytokinesIBA 01/01/2022 - "Systemic and Local Cytokines Profile Determine Severity and Prognosis in Human Septic Arthritis." 01/01/2021 - "Assessment of synovial fluid and serum cytokine levels in children with septic arthritis." 01/01/2018 - "aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease." 12/01/2017 - "Role of Th17 and Treg cells in septic arthritis and the impact of the Th17/Treg -derived cytokines in the pathogenesis of S. " 06/01/2017 - "aureus-Induced Septic Arthritis by Differential Alteration of Local and Systemic Proinflammatory Cytokines in Mice."
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1996 - "Further study is needed to prove safety and efficacy of corticosteroids before recommending their clinical use in the treatment of septic arthritis." 09/05/2015 - "This study therefore set out to review current literature with regards to a possible beneficial effect for corticosteroids in Septic Arthritis. " 11/21/2018 - "Corticosteroids for septic arthritis in children." 09/05/2015 - "A computerised search of the databases MEDLINE and CINAHL was conducted during November 2014 using the EBSCOhost web search engine in order to identify research articles relating to the use of corticosteroids in the treatment of septic arthritis. " 09/05/2015 - "A systematic review and meta-analysis regarding the use of corticosteroids in septic arthritis."
5.	Dexamethasone (Maxidex)FDA LinkGeneric 09/01/2014 - "In this study, the effect of intravenous dexamethasone on septic arthritis, and the recovery process of the disease have been evaluated. " 09/01/2014 - "The effect of intravenous dexamethasone in the treatment of septic arthritis." 10/01/2003 - "These results suggest that a 4-day course of low dose dexamethasone given early benefits children with hematogenous septic arthritis." 10/01/2003 - "A short course of dexamethasone reduced residual joint dysfunction and shortened significantly the duration of symptoms in children with documented hematogenous septic arthritis. " 10/01/2003 - "In a double blind manner we randomly selected 123 children with suspected hematogenous bacterial arthritis to receive dexamethasone or saline for 4 days. "
6.	DNA (Deoxyribonucleic Acid)IBA 06/01/2009 - "kingae real-time PCR applied to DNA extracted from joint fluid samples, but not from blood samples, markedly improved the etiological diagnosis of septic arthritis in children. " 11/01/2009 - "In this study, we analyzed the putative diagnostic value of synovial cf-DNA/NETs for identification of septic arthritis. " 11/01/2009 - "Diagnostic accuracy of neutrophil-derived circulating free DNA (cf-DNA/NETs) for septic arthritis." 10/01/2007 - "Indeed, PCR represents an undeniable benefice for the diagnosis of paediatric septic arthritis, particularly for the DNA detection of K. " 01/01/2007 - "We could detect DNA from various bacterial pathogens including fastidious bacteria (Kingella kingae, Streptococcus pneumoniae, Streptococcus pyogenes, Salmonella spp, Staphylococcus aureus) from 23% of cases of septic arthritis giving negative culture results. "
7.	Hyaluronic Acid (Hyaluronan)IBA 02/01/1992 - "Sodium hyaluronate with joint lavage appears to be more beneficial than lavage alone for treatment of septic arthritis." 02/01/1992 - "Evaluation of sodium hyaluronate therapy in induced septic arthritis in the horse." 03/01/2017 - "In this study, we described three cases of acute pseudoseptic arthritis that was caused by hyaluronic acid; the symptoms in these cases were reminiscent of acute septic arthritis. " 02/01/1992 - "This study was conducted to determine the efficacy of sodium hyaluronate (SH) with antibiotic therapy and joint lavage for reducing acute inflammatory and degenerative changes induced by septic arthritis. " 11/01/2007 - "Naturally derived sodium hyaluronates have not been associated with pseudosepsis; we describe a case of severe arthritis mimicking acute septic arthritis after naturally hyaluronan. "
8.	TeicoplaninIBA 03/01/1999 - "Patients with proven Gram-positive osteomyelitis or septic arthritis were treated with once-daily teicoplanin, 6-12 mg/kg per day, after three loading doses at intervals of 12 h, for 4-6 weeks. " 04/01/1994 - "It is suggested that 6 mg/kg day(-1) of teicoplanin be used for all indications except staphylococcal endocarditis and septic arthritis when it should be given in a dose of 12 mg/kg day(-1) or in combination with other agents." 01/01/1992 - "Teicoplanin was safe, effective, convenient and relatively well tolerated in patients with acute or chronic osteomyelitis or septic arthritis." 01/01/1997 - "There are 3 exceptions for which the daily maintenance dosage should be 12 mg/kg/day and these are intravenous drug abusers, septic arthritis (but not osteomyelitis), and Staphylococcus aureus endocarditis treated with teicoplanin monotherapy. " 08/01/1993 - "To evaluate the efficacy and safety of teicoplanin in the treatment of gram-positive bone and joint infections, parenteral teicoplanin was used once daily in an average dose of 10.1 mg/kg (range 6 to 12 mg/kg) after loading to treat patients with acute or chronic osteomyelitis and septic arthritis. "
9.	Doxycycline (Periostat)FDA LinkGeneric 02/01/2008 - "In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis." 06/22/1991 - "A 37-year-old patient had fever, diffuse maculopapular rash and acute suppurative arthritis of both knees, which was totally cured with doxycycline without sequelae. " 04/01/2022 - "A 30-year-old woman developed infective endocarditis, septic arthritis, and reactive arthritis concurrently one week after undergoing dilation and curettage for an incomplete abortion with perioperative administration of doxycycline. " 11/09/2022 - "parvum septic arthritis with ciprofloxacin and doxycycline, the patient experienced a full neurological recovery, and continues on suppressive doxycycline therapy with no recurrence of symptoms to date." 07/24/2017 - "We present a case of Q fever prosthetic joint septic arthritis that has responded to a combination of two-stage surgical exchange and prolonged medical treatment with doxycycline and hydroxychloroquine."
10.	Ciprofloxacin (Cipro)FDA LinkGeneric 10/01/1985 - "We investigated the in vivo efficacy of ciprofloxacin in a rabbit model of septic arthritis due to Escherichia coli. " 08/01/1993 - "The role of ciprofloxacin in septic arthritis caused by Gram-negative bacilli is also reviewed." 07/01/1986 - "Ciprofloxacin was compared with ceftriaxone in a rabbit model of septic arthritis caused by Escherichia coli. " 11/09/2022 - "parvum septic arthritis with ciprofloxacin and doxycycline, the patient experienced a full neurological recovery, and continues on suppressive doxycycline therapy with no recurrence of symptoms to date." 09/01/2016 - "A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia."

Therapies and Procedures

1.	Therapeutics 05/01/2021 - "Good results have been reported with arthroscopic therapy of septic arthritis of the shoulder; however, few studies have focused on the risk factors for failure of arthroscopic surgery. " 12/01/1997 - "Antimicrobial therapy was effective in ensuring resolution of the infectious arthritis. " 07/01/2007 - "Appropriate therapy was promptly instituted and the septic arthritis responded well, necessitating hip aspiration only once. " 01/01/1992 - "100% of the septic arthritis patients were cured at the end of therapy and at 1-month follow-up. " 05/01/2009 - "Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis."
2.	Debridement 10/01/2018 - "Septic arthritis after arthroscopic posterior cruciate ligament and multi-ligament reconstructions is rare and can be successfully treated with arthroscopic irrigation and debridement: analysis of 866 reconstructions." 07/11/2023 - "Arthroscopic management of native knee septic arthritis is a safe and effective alternative to open treatment and is associated with comparable complication rates, reoperation rates, hospitalization lengths, readmission rates, and superior patient-reported outcomes compared with open irrigation and debridement. " 01/01/2021 - "Debridement by arthrotomy in the emergency department by non-sub-specialist knee surgeons is more effective than arthroscopic debridement in controlling septic arthritis of the knee. " 05/01/2016 - "Continuous negative pressure, following open arthrotomy, irrigation and debridement, was effective in treating septic arthritis of the shoulder. " 04/01/2014 - "Arthroscopic lavage and debridement is a safe and effective procedure for septic arthritis of the hip joint."
3.	Anterior Cruciate Ligament Reconstruction 06/01/2022 - "In this study, patients who were treated for postoperative septic arthritis of the knee following anterior cruciate ligament reconstruction between 2006 and 2018 were evaluated at a minimum follow-up (FU) of 2 years. " 10/01/2019 - "Professional Athletes Are at Higher Risk of Septic Arthritis After Anterior Cruciate Ligament Reconstruction: An Analysis of 4421 Consecutive Patients Including 265 Elite Athletes From the SANTI Study Group." 10/01/2023 - "Poorer patient-reported outcome and increased risk of revision at a 5-year follow-up among patients with septic arthritis following anterior cruciate ligament reconstruction: a register-based cohort study of 23,075 primary anterior cruciate ligament reconstructions." 07/01/2023 - "Septic arthritis of the knee following anterior cruciate ligament reconstruction is a rare but potentially deleterious complication. " 07/01/2023 - "Approaches to Septic Arthritis of the Knee Post Anterior Cruciate Ligament Reconstruction."
4.	Length of Stay 03/01/2010 - "Arthroscopic irrigation and débridement is an effective treatment for patients with isolated septic arthritis of the wrist; these patients had fewer operations and a shorter hospital stay than did patients who had received open treatment. " 06/01/2009 - "Arthroscopic irrigation and débridement is an effective treatment for patients with isolated septic arthritis of the wrist; these patients had fewer operations and a shorter hospital stay than did patients who had received open treatment. " 03/07/2022 - "The aim of this study was to identify the clinical features and risk factors for longer hospital length of stay (LOS), positive blood culture, and in-hospital mortality in dialysis patients with septic arthritis. " 03/01/2005 - "This study suggests that primary closure is a viable alternative to delayed primary closure with shorter hospital stays and similar outcomes in children with idiopathic septic arthritis. " 12/01/2022 - "Reduced Costs, Complications, and Length of Stay After Arthroscopic Versus Open Irrigation and Débridement for Knee Septic Arthritis."
5.	Arthroplasty 05/01/1987 - "This patient's disease course shows that gram-negative septic arthritis, effectively treated, does not preclude successful total joint arthroplasty." 01/01/2022 - "The aims of this study are to investigate the outcome and predictors of septic failure following total joint arthroplasty (TJA) for prior septic arthritis. " 03/01/2021 - "retrospective consecutive study of patients with previous history of septic arthritis who underwent MRI scans of their hips prior to primary hip arthroplasty surgery and who also had minimum 2 years follow up postoperatively. " 05/16/2011 - "This study presents the medium-term results of a new, standardized two-stage arthroplasty with preformed hip spacers and cementless implants in a consecutive series of adult patients with septic arthritis of the hip treated according to a same protocol. " 12/01/2010 - "The aim of the present study was to analyze the results of arthroplasties after septic arthritis of native knee and hip joints, in terms of functional results and infection control and to seek eventual risk factors of failure. "