|4.||Autoimmune Diseases (Autoimmune Disease)
|5.||Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
|1.||Holmdahl, Rikard: 59 articles (08/2015 - 05/2002)|
|2.||Wei, Wei: 34 articles (04/2015 - 09/2002)|
|3.||Park, Sung-Hwan: 32 articles (10/2015 - 04/2002)|
|4.||Kim, Ho-Youn: 31 articles (10/2015 - 04/2002)|
|5.||Cho, Mi-La: 31 articles (10/2015 - 03/2006)|
|6.||van den Berg, Wim B: 30 articles (11/2015 - 01/2003)|
|7.||Nandakumar, Kutty Selva: 24 articles (08/2015 - 09/2002)|
|8.||Williams, Richard O: 17 articles (10/2014 - 01/2002)|
|9.||Myers, Linda K: 16 articles (10/2015 - 01/2002)|
|10.||Lubberts, Erik: 16 articles (06/2014 - 11/2002)|
|1.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/01/2007 - "MDA levels decreased in Groups III-V when compared with Group II. GSH levels significantly increased in Group III and IV than Group V. SOD activity of Group IV was higher than Group III and V. TNF-alpha levels were significantly lower in Group IV and V. LC and alpha-LA seemed to have protective effects against oxidative damage in adjuvant arthritis model."
04/01/2009 - "In mice with collagen-induced arthritis, Nov038 enabled the therapeutic administration of CD40-ASO and improved established disease, while unassisted CD40-ASO was ineffective, and anti-tumor necrosis factor alpha (anti-TNFalpha) treatment was less effective in this model. "
09/01/2008 - "Anti-cytokine induction of autoimmune protection against chronic hTNFalpha overproduction is an efficient alternative to TNFalpha blockade in experimental arthritis and can be achieved using a TNFK vaccine."
03/01/2010 - "This study focused on the potential therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on collagen-induced arthritis (CIA) and on the elucidation of the mechanisms involved. "
10/01/2015 - "Thus, it lowers the formation of tumor necrosis factor (TNF)-α, a proinflammatory cytokine, and was found to be an oral antiarthritic therapeutic in murine collagen-induced arthritis in vivo. "
|2.||Collagen Type II (Type II Collagen)IBA
09/01/2010 - "The therapeutic mechanisms and efficacy of low-dose MTX and the oral tolerance protein natural chicken type II collagen (nCCII) were compared in vitro and in vivo using an established collagen-induced arthritis (CIA) rat model. "
07/10/1996 - "We then tested aerosolization of a different autoantigen in a different disease model and found that aerosolization of type II collagen was effective in suppressing collagen-induced arthritis. "
04/01/2008 - "Oestrogen exhibits type II collagen protective effects and attenuates collagen-induced arthritis in rats."
11/01/2013 - "Water-soluble undenatured type II collagen ameliorates collagen-induced arthritis in mice."
12/01/1989 - "Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis."
|3.||Methotrexate (Mexate)FDA LinkGeneric
10/01/2015 - "The study aimed to illustrate application of polycation Stealth nanogels for sustained delivery of methotrexate (MTX) in collagen induced arthritis (CIA) model in C57Bl/6 mice. "
08/01/1988 - "Methotrexate suppresses passive adjuvant arthritis: studies on the metabolism of methotrexate in mononuclear cells derived from normal and adjuvant arthritic rats."
10/01/1985 - "Studies on the effect of low dose methotrexate on rat adjuvant arthritis."
03/01/2015 - "We tested the hypothesis that micro-computed tomography (micro-CT) analysis provides a better quantitative readout of the therapeutic potential of methotrexate (MTX) for treating collagen-induced arthritis (CIA) in rats and compared to conventional histopathological examination. "
03/01/2015 - "Effect of methotrexate on collagen-induced arthritis assessed by micro-computed tomography and histopathological examination in female rats."
03/01/2002 - "In vivo administration of an I-A(q) fusion protein, containing an immunodominant collagen II peptide, significantly delayed the onset and reduced the severity of collagen-induced arthritis in DBA/1 mice by induction of Ag-specific hyporesponsiveness. "
04/01/2013 - "IL-22-deficient mice exhibit an intact humoral and cellular immune response to collagen and yet have a reduced incidence of collagen-induced arthritis (CIA). "
08/01/2012 - "In this study, we used chicken collagen II-induced experimental arthritis (CIA) model in DBA/1 mice to investigate the relationship between IL-25 and other inflammatory factors, revealing the possible mechanism in CIA. "
02/01/2012 - "The aim of the present study was to ascertain the modulatory ability of a cocoa flavonoid-enriched diet on collagen-induced arthritis (CIA), which is mediated by anti-collagen autoantibody response and Th lymphocyte activation. "
01/01/2011 - "In the current study, we investigated the effects of WBM and shiitake mushrooms (SM) on collagen-induced arthritis (CIA) using a 2 x 3 factorial design in 8-wk-old female dilute brown non-agouti mice that were fed a control diet (n = 37) or the same diet supplemented with 5% lyophilized WBM or SM (n = 27) for 6 wk. CIA was induced by immunizing mice with 100 µg bovine collagen followed by 50 µg LPS on d 20 post-collagen injection. "
03/01/2010 - "Mesenchymal stem cells significantly enhance the efficacy of collagen-induced arthritis treatment, likely through the modulation of the expression of various cytokines."
08/01/2015 - "In this study, we observed the kinetic changes of the B10 cells in collagen-induced arthritis (CIA) mice and the influence of multiple cytokines on the B10 cells to investigate the potential mechanism underlying the changes of B10 cells. "
02/10/2005 - "Therefore, this study was undertaken to address (1) whether the water extract of the bark of Ulmus davidiana Planch (Ulmaceae) (UD) can modulate the expression of inducible inflammatory cytokines in mice; (2) in order to assess the therapeutic effects of UD in collagen-induced arthritis (CIA) in mice. "
03/01/1998 - "Moreover, collagen-induced arthritis has proven a valuable model to study the contribution of cytokines and other biological agents in the pathogenesis of joint injury and how they might be used to develop new therapies. "
08/01/2015 - "Kinetic changes of regulatory B10 cells in collagen-induced arthritis could be regulated by cytokines IFN-γ and TGF-β1."
|6.||Interleukin-10 (Interleukin 10)IBA
12/01/2000 - "In the rat adjuvant arthritis model, treatment with systemic murine IL-10 (mIL-10) effectively suppressed all disease parameters in rats that received the lower concentrations of mycobacteria, whereas systemic mIL-4 was effective against even the most severe disease. "
05/15/2001 - "Studies of collagen-induced arthritis have shown efficacy with repeated administrations of IL-10; however, when the EBV IL-10 homologue was administered via adenovirus gene transfer technology the results were equivocal. "
01/01/2012 - "Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice."
02/01/2003 - "Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis."
08/15/1999 - "Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees."
|7.||Interleukin-1 (Interleukin 1)IBA
04/01/2008 - "Development of interleukin-1 receptor antagonist mutants with enhanced antagonistic activity in vitro and improved therapeutic efficacy in collagen-induced arthritis."
09/01/2003 - "Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist."
05/01/1997 - "To determine the efficacy of local human interleukin-1 receptor antagonist (HuIL-1Ra) gene therapy in murine collagen-induced arthritis (CIA). "
09/01/2007 - "In the present study, we demonstrate for the first time that inhibition of TLR-4 suppresses the severity of experimental arthritis and results in lower IL-1 expression in arthritic joints. "
10/01/2003 - "In this study we demonstrated that sIL-1RAcP is a biologically active and innovative inhibitor of IL-1, and treatment of mice with sIL-1RAcP had a profound prophylactic effect on collagen-induced arthritis."
04/01/2009 - "Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis."
11/01/2003 - "These liposomes were shown to be stable in the circulation and equally effective in rat experimental arthritis as PLP encapsulated in PEG-liposomes. "
07/01/1985 - "The present study investigates the effectiveness of the beta-emitting isotope lutetium-177, delivered in chelator liposomes, in treating an experimental arthritis in rabbits. "
01/01/2015 - "SOD-enzymosomes showed earlier therapeutic activity than both SOD-liposomes and free SOD in rat adjuvant arthritis. "
02/12/2007 - "The potential therapeutic effect of Ac-SOD enzymosomes was compared with SOD liposomes in a rat model of adjuvant arthritis. "
04/08/2010 - "In particular, compound 3f is highly potent in the enzyme and cell-based assays, selective in an Ambit kinase screen, and efficacious (ED(50) < or = 0.01 mg/kg) in the rat collagen induced arthritis (CIA) model."
08/01/2006 - "MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis."
01/01/2014 - "The preclinical pharmacokinetic (PK)/pharmacodynamic (PD) profile of tofacitinib, an oral Janus kinase (JAK) inhibitor, in a mouse collagen-induced arthritis (mCIA) model was compared with clinical PK/PD data from patients with rheumatoid arthritis (RA). "
01/01/2014 - "A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints."
01/01/2007 - "FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice."
|10.||Immunoglobulin G (IgG)IBA
12/15/2013 - "The objective of this study was to determine if allogeneic MSCs migrate to inflamed joints in vivo and to determine if MSCs expressing the costimulation blocker cytotoxic T lymphocyte associated antigen-4 coupled to immunoglobulin-G (CTLA4Ig) could be used to ameliorate collagen induced arthritis (CIA). "
02/01/1997 - "Since previous studies have demonstrated the importance of IgG2 antibody subclasses to the induction of collagen-induced arthritis, total immunoglobulin G (IgG), IgG1, and IgG2a and IgG2b were measured. "
12/01/1984 - "Passive transfer of collagen arthritis: studies with affinity-purified anticollagen IgG prepared in rabbits."
01/01/2014 - "The onset of collagen induced arthritis was preceded by an increase of anti-CarP IgG2a levels in the serum. "
11/01/2006 - "The level of C II- and C II (250-270)- specific IgG in serum from the mice fed with rhC II (250-270) were (0.82+/-0.02) and (0.84+/-0.04) respectively, and lower significantly than those of collagen-induced arthritis (CIA) control group. "
11/01/2013 - "The present study was designed to examine the oral administration of a novel, water-soluble, undenatured C II (commercially known as NEXT-II) on collagen-induced arthritis (CIA) in mice. "
09/01/2014 - "Here we demonstrate the experimental evidence that oral administration of NAM could completely prevent the occurrence of experimental arthritis in CIA mouse model at 0.3 mg/kg with ED50 value of approximately 0.1 mg/kg twice daily. "
12/15/2013 - "TASP0415914 demonstrated good potency in a cell-based assay and, furthermore, exhibited in vivo efficacy in a collagen induced arthritis (CIA) model in mice after oral administration. "
12/01/2007 - "The anti-rheumatic effects were evaluated by treating mice with collagen-induced arthritis (CIA) using a daily oral administration of BT-201 at 15 mg/kg/day. "
02/01/2003 - "The therapeutic effect of oral administration of CII is obvious on adjuvant arthritis in rats. "
10/01/1992 - "One hour before MSU injection, intra-articular administration of a 1.0% solution of Na-HA with different molecular weights, ranging from 4.70 x 10(5) to 2.02 x 10(6) (HA-200), improved the score of abnormal gait in a molecular weight-dependent manner in the experimental arthritis model. "
02/01/2015 - "The intraarticular injection of RasGRP-4-specific siRNAs also dampened experimental arthritis in rats. "
01/01/2012 - "To demonstrate the therapeutic potential for cartilage repair of mesenchymal stem cells derived from human umbilical cord (HUCSC), we studied the clinical and histopathological effects of intra-articular injection of HUCSCs in a collagen-induced arthritis (CIA) model. "
01/01/2011 - "Both classes of molecules were reported to induce experimental arthritis in rodents following direct intra-articular injection. "
08/01/1998 - "To determine the effects on collagen-induced arthritis of vIL-10 gene transfer, DBA/1 mice were administered i.v. or intra-articular injections of Av(vIL-10), a replication-deficient adenovirus encoding vIL-10. "
|3.||Transplantation (Transplant Recipients)
12/01/1989 - "Transplantation of syngeneic bone marrow is as effective as that of allogeneic bone marrow from a rat strain that is not susceptible to induction of adjuvant arthritis. "
01/01/2015 - "Remission of collagen-induced arthritis through combination therapy of microfracture and transplantation of thermogel-encapsulated bone marrow mesenchymal stem cells."
07/01/2015 - "Transplantation of human amnion mesenchymal cells attenuates the disease development in rats with collagen-induced arthritis."
08/01/1998 - "More unexpectedly it was found that experimental adjuvant arthritis (AA) and experimental allergic encephalomyelitis (EAE) could be cured by means of total body irradiation (TBI) followed by autologous hemolymphopoietic stem cell (HSC) transplantation. "
01/01/2015 - "MSCs transplantation (MSCT) into collagen-induced arthritis (CIA) mice prevented arthritis progression by inhibiting both the number and function of Tfh cells in vivo. "
01/01/2015 - "We have previously demonstrated that semimature dendritic cell- (smDC-) based immunotherapy is effective for the treatment of collagen-induced arthritis (CIA) prior to disease onset. "
04/01/2004 - "Immunotherapy in collagen-induced arthritis: past, present, and future."
05/01/1993 - "T cell-targeted immunotherapy in murine collagen-induced arthritis."
08/01/1990 - "Immunotherapy of collagen-induced arthritis by a T-cell antiproliferative molecule."
06/01/1989 - "Experimental immunotherapy of murine collagen-induced arthritis can be achieved by administration of specific T suppressor cell hybridomas. "
05/01/2001 - "The present study investigates the efficacy of long-term prophylactic enzyme therapy and combination therapy with cyclosporin A in rats with collagen-induced arthritis. "
01/01/1999 - "This study investigates the efficacy of both enzyme therapy and combined therapy with cyclosporin in rats with adjuvant arthritis. "
05/01/2001 - "Inhibitory effect of enzyme therapy and combination therapy with cyclosporin A on collagen-induced arthritis."
05/01/2001 - "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin A given in low doses in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis."
01/01/1999 - "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis."