|1.||Holmdahl, Rikard: 118 articles (01/2016 - 01/2002)|
|2.||van den Berg, Wim B: 61 articles (11/2015 - 02/2002)|
|3.||Glant, Tibor T: 52 articles (02/2014 - 01/2002)|
|4.||Schett, Georg: 46 articles (10/2015 - 01/2003)|
|5.||Nandakumar, Kutty Selva: 45 articles (08/2015 - 09/2002)|
|6.||Mikecz, Katalin: 43 articles (01/2014 - 01/2002)|
|7.||Cho, Mi-La: 40 articles (10/2015 - 05/2006)|
|8.||Park, Sung-Hwan: 38 articles (10/2015 - 04/2002)|
|9.||Tak, Paul P: 38 articles (09/2015 - 10/2002)|
|10.||Huizinga, Tom W J: 38 articles (08/2015 - 02/2004)|
|1.||Methotrexate (Mexate)FDA LinkGeneric
03/01/1993 - "Liposomal methotrexate suppressed the development of arthritis at a dose one-tenth that of the free drug and it was also effective in suppressing arthritis of 7 days duration, although significant beneficial effects of liposomal methotrexate were delayed for 10 to 14 days after injection. "
08/01/2000 - "The use of low-dose oral methotrexate (MTX) for persistent polyarthritis has been shown to be effective by the USA/USSR collaborative study group. "
01/01/2015 - "Methotrexate is effective in treating inflammatory arthritis, but both underadherence and overadherence can put patients at risk. "
02/01/1998 - "Methotrexate appears to be effective in the treatment of antimalarial resistant lupus arthritis and is well tolerated."
11/01/1995 - "Methotrexate has been reported to be effective in various animal models of arthritis as well as a variety of human disorders without a shared pathogenesis. "
|2.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/01/2005 - "Cross-sectional observations from an outpatient arthritis clinic found a significantly higher remission rate in patients with RA taking a TNF-alpha inhibitor compared to non-users."
03/01/1998 - "Serum levels of TNF alpha in rats that develop arthritis are significantly greater (2.4 fold) than levels from the other groups. "
10/20/2015 - "Antagonists of tumor necrosis factor-α (TNFα) and IL-1β were equally effective in suppressing arthritis in wild-type mice, while IL-1β blockade was more effective than TNFα blockade in Ncf1(-/-) mice. "
01/01/2009 - "Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis."
01/01/2012 - "In contrast, tumor necrosis factor (TNF) inhibitor proved effective against arthritis and skin lesions in these patients. "
|3.||Collagen Type II (Type II Collagen)IBA
08/01/2006 - "In the type II collagen-induced arthritis model, we observed a significant reduction in clinical scores (p < 0.01) in three independent experiments and diminished joint pathology (p < 0.005) in PKC-theta-deficient compared with wild-type littermates. "
01/01/2000 - "Compound 19a (ED40 = 3.6 mg/kg in established AA) possessed good therapeutic efficacy against type II collagen-induced arthritis in DBA/1J mice with doses of 30 and 100 mg/kg, suggesting the development of 19a (designated T-614) as a prospective disease-modifying antirheumatic agent. "
06/01/1985 - "Despite no difference in clearance of anti-type II collagen antibody after transfer between them, the passively transferred arthritis in rnu/rnu rats was significantly enhanced and prolonged in comparison with that in rnu/+ rats. "
05/01/2010 - "Previous research has shown that undenatured type II collagen is effective in the treatment of arthritis. "
07/25/2002 - "Gene therapy of IL-ira via non-virus eukaryotic expression vactor, especially by gene gun, is effective in treating arthritis induced by type II collagen."
01/01/2013 - "Thus, antigen-specific gene therapy is effective when administered throughout the inflammatory course of arthritis and offers a good model for investigation of the basic mechanisms during tolerance in CIA. "
04/01/1997 - "Animals treated with manipulation and exercise improved significantly relative to untreated animals with antigen-induced arthritis in vertical ankle lift, ankle-based and foot-based stride lengths, knee circumference, and normalized extension of the ankle. "
04/01/1980 - "The lymphocyte stimulation induced by gonococcal antigen was significantly greater in patients with postgonorrhoeal arthritis than in healthy controls. "
01/01/2014 - "Specific in vivo localization and therapeutic efficacy of 1-11E/vIL-10 was tested in the mouse model of antigen-induced arthritis. "
10/01/2002 - "The scFv TS-A12/22 was tested in a rat model of antigen-induced arthritis and proved to be effective in preventing influx of polymorphonuclear cells into the knee joint and C9 deposition on synovial tissue."
11/10/2012 - "After selecting the best candidate among those derivatives, its therapeutic efficacy on arthritis was investigated in a murine collagen antibody-induced arthritis (CAIA) model. "
06/01/2012 - "On adoptive transfer of in vitro expanded B10 cells, collagen-immunized mice showed a marked delay of arthritis onset with reduced severity of both clinical symptoms and joint damage, accompanied by a substantial reduction in the number of Th17 cells. "
01/01/1989 - "However, administration of anti-CD8 mAb two weeks after pre-immunization with soluble collagen was very effective in reversing arthritis resistance. "
01/01/2010 - "Vaccination of mice with MBP-C5a led to significant reduction of arthritis incidence and severity but not anti-collagen antibody synthesis. "
11/01/2007 - "Blood neutrophils from arthritis patients in remission existed in a primed state as revealed by more rapid oxidative response after collagen-bead challenge and a more pronounced response after fMLF stimulation compared to healthy blood donors. "
|6.||infliximab (Remicade)FDA Link
01/01/2006 - "Efficacy of interferon-alpha-2a has also been reported for mucocutaneous lesions, arthritis, and (more anecdotally) for neuro-Behçet, while results from small case series suggest that infliximab is beneficial for mucocutaneous lesions and (more anecdotally) for arthritis and gastro-intestinal manifestations. "
03/01/2013 - "Safety and efficacy of intra-articular infliximab therapy for treatment-resistant temporomandibular joint arthritis in children: a retrospective study."
10/01/2004 - "All 3 patients with joint involvement experienced remission of arthritis, which relapsed 8-11 weeks after the last infliximab infusion. "
02/01/2007 - "The concomitant onset of polyarthritis in three cases raises the need to investigate the incidence of autoimmune manifestations in psoriatic patients receiving infliximab in further large-scale studies."
07/01/2006 - "Of the study group of 96 patients (arthritis duration 16 years (range 3 to 43)), 74 completed one year of infliximab treatment. "
|7.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/01/2009 - "Current clinical treatment for arthritis is confined to Non Steroidal Anti-Inflammatory Drugs (NSAIDs), which are effective in treating symptoms but fail to block the progression of the disease. "
01/01/2007 - "The data that have accumulated in recent years underscore the importance of carefully weighing the risks and benefits of traditional NSAIDs and COX-2 selective inhibitors before making therapeutic decisions for the management of chronic arthritis. "
05/01/1999 - "Non-steroidal anti-inflammatory drugs (NSAIDs) are effective for arthritis but cause gastrointestinal injury. "
01/01/1989 - "Non-steroidal anti-inflammatory drugs (NSAIDs) are effective in relieving the symptoms of arthritis, but may have serious side-effects such as gastrointestinal lesions. "
03/01/2012 - "Improved percutaneous delivery of some NSAIDs for the treatment of arthritis."
|8.||TNFR-Fc fusion protein (etanercept)FDA Link
06/01/2015 - "Long-term therapy with etanercept was relatively safe and had remarkable long-term efficacy for refractory lupus arthritis. "
01/01/2003 - "In conclusion, etanercept has emerged as an important new treatment option in inflammatory arthritis. "
01/01/2002 - "In conclusion, etanercept has emerged as an important new treatment option in inflammatory arthritis. "
11/01/2002 - "In a phase 2, randomized, placebo-controlled trial of 60 patients with PsA, etanercept 25 mg subcutaneously twice weekly resulted in significantly more improvement in arthritis and skin symptoms than placebo. "
12/01/2009 - "Under therapy with etanercept patients of all JIA subgroups significantly improved their functional ability (P < 0.0001), but patients with polyarthritis less frequently improved their physical functioning. "
|9.||Antirheumatic Agents (DMARD)IBA
04/01/2015 - "To evaluate the efficacy of anti-rheumatic agents in animal models of arthritis, we developed a high throughput knee and ankle joint imaging assay to measure BMD as a translational biomarker. "
01/01/2011 - "The disease outcomes studied were fulfillment of the 1987 ACR-RA criteria and arthritis persistence in UA patients and the rate of radiological joint destruction and achieving sustained DMARD-free remission in RA patients. "
05/01/2012 - "Biological disease-modifying anti-rheumatic drugs (bDMARDs) are effective in the management of inflammatory arthritides. "
06/01/1986 - "MTX is an effective agent for the treatment of inflammatory arthritis in patients who do not respond to therapy with nonsteroidal anti-inflammatory drugs or slow-acting antirheumatic drugs. "
03/01/2014 - "Conduct a retrospective analysis of inactive arthritis status, remission on medication and remission off medication, estimating cumulative probability and mean time to survival, from the first joint injection session to the last follow-up visit or disease-modifying anti-rheumatic drugs initiation. "
01/01/2013 - "The most often studied disease model has been murine inflammatory arthritis, where a clear mechanism for the efficacy of CD44 antibodies has not been established. "
01/01/2015 - "Bispecific anti-TNFα/IL-17 antibodies may have superior efficacy in the treatment of arthritis and may overcome the limited therapeutic responses obtained with single cytokine neutralization."
11/01/2005 - "With a higher specificity, values for RA, anti-CCP, and AKA seem to be helpful for the differential diagnosis of patients with RF-positive arthritis, which may include patients with WG and pSS, and screening of all three antibodies may increase the diagnostic performance."
03/01/2009 - "Anticyclic citrullinated antibodies and prediction rules have improved our ability to estimate the risk of progression to RA in individual patients presenting with early inflammatory arthritis. "
04/01/2006 - "Anti-VCP antibodies are helpful in discriminating RA from other chronic arthritides or connective tissue disorders. "
01/01/2011 - "Arthroplasty for arthritis has led to remarkable improvement in patient quality of life and alleviation of symptoms. "
12/01/2008 - "Total joint arthroplasty is a highly efficacious and cost-effective procedure for moderate to severe arthritis in the hip and knee. "
10/01/2008 - "Uncemented total hip arthroplasty was found to confer a significant improvement in function and to have an acceptable short-term outcome in very young patients with end-stage arthritis of the hip. "
09/01/2006 - "Total knee arthroplasty (TKA) is a well-established procedure, and has proven to be durable and effective for the treatment of advanced arthritis of the knee joint. "
04/01/2006 - "Total joint arthroplasty is very effective for improving the quality of life of patients with end-stage arthritis. "
01/01/2014 - "We have concluded that, taking into account the small power of the present study, talonavicular arthrodesis is a successful treatment for isolated talonavicular arthritis. "
01/01/2013 - "Though it reported a greater risk of major complications after surgery, subtalar arthrodeses for the development of subtalar arthritis was significantly greater after conservative treatment.Overall"
09/01/2004 - "Arthrodesis remains the mainstay of treatment of end-stage arthritis of the foot and ankle. "
01/01/1998 - "We conclude that isolated subtalar arthrodesis with internal compression was effective treatment for post-traumatic subtalar arthritis. "
01/01/1991 - "Arthrodesis is a safe and effective way of treating isolated painful arthritis in the trapeziometacarpal joint; solid fusion occurred in 39 cases, and four patients had fibrous union. "
09/01/2010 - "Intraarticular corticosteroid injections are beneficial in the local treatment of JIA and of other types of arthritis. "
01/01/2015 - "This may improve the accuracy and efficacy of corticosteroid injections in the treatment of distal radioulnar joint arthritis without the need for image guidance."
03/01/2014 - "Our aim was to estimate arthritis remission probability after single or repeated injections. "
01/01/2010 - "Two patients experienced full remission after 6 months and only one injection, 1 patient (arthritis of the wrist) was in remission after 2 injections (3 months of interval). "
09/01/2004 - "In unresponsive tarsal arthritis, the synovitic sites should be targeted by radiological imaging to improve the efficacy of corticosteroid injections. "
12/01/2013 - "Most recently, treatments involving intra-articular injection of MSCs have shown great promise for cartilage repair and arthritis therapy, which rely on MSC adhesion to cartilage. "
01/01/2006 - "Intra-articular injection of the NBD peptide led to significantly reduced severity of arthritis (p < 0.0001) and reduced radiological damage (p = 0.04). "
09/01/1999 - "Intra-articular injection of 2 ml of 0.9% NaCl solution was beneficial in horses with traumatic arthritis. "
01/01/2012 - "In our study, intra-articular injection of HUCSCs had no benefit in CIA mice; and accelerated the progression of arthritis in the presence of TNF-α. "
06/01/2009 - "Biodistribution studies were carried out by intra-articular injection into knee joints of Wistar rats induced with chronic inflammatory arthritis using CFA and by monitoring the radioactivity for retention and leakage. "
|5.||Drug Therapy (Chemotherapy)
05/01/1976 - "Type of drug therapy tended to reflect severity of arthritis, rather than vice versa, and functional capacity improved significantly from entry to last evaluation in both males and females, even though the latter had stable or progressive arthritis. "
12/01/2000 - "The leukemic arthritis responded well to chemotherapy. "
06/01/2000 - "The arthritis had minimal improvement with the chemotherapy. "
09/01/2013 - "Drug therapy in undifferentiated arthritis: a systematic literature review."
10/01/2012 - "Respondents with arthritis reported whether they had used each of seven drug therapies in the past year. "