Arteriovenous Malformations (Arteriovenous Malformation)

Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.

Also Known As:

Arteriovenous Malformation; Malformation, Arteriovenous; Malformations, Arteriovenous

Networked: 2540 relevant articles (102 outcomes, 153 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Intracranial Aneurysm (Cerebral Aneurysm)
2.	Hemorrhage
3.	Arteriovenous Malformations (Arteriovenous Malformation)
4.	Neoplasms (Cancer)
5.	Aneurysm (Aneurysms)

Experts

1.	Lawton, Michael T: 33 articles (03/2022 - 04/2003)
2.	Young, William L: 33 articles (04/2015 - 04/2003)
3.	Kim, Helen: 19 articles (01/2022 - 10/2007)
4.	Su, Hua: 15 articles (01/2022 - 12/2008)
5.	Do, Young Soo: 15 articles (01/2021 - 05/2005)
6.	Yang, Guo-Yuan: 14 articles (09/2017 - 04/2003)
7.	Pawlikowska, Ludmila: 13 articles (01/2021 - 10/2005)
8.	McCulloch, Charles E: 12 articles (01/2021 - 10/2005)
9.	Park, Kwang Bo: 12 articles (01/2021 - 06/2005)
10.	Spetzler, Robert F: 12 articles (05/2020 - 09/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arteriovenous Malformations:

1.	Ethanol (Ethyl Alcohol)IBA 03/01/2008 - "Ethanol embolization is effective for the treatment of pelvic arteriovenous malformations, though there is a chance of a major complication." 09/01/2019 - "To evaluate the safety and efficacy of ethanol and coil embolization of type II arteriovenous malformation (AVM) according to a new subtype classification. " 01/01/2022 - "To evaluate the safety and efficacy of ethanol embolization of lip arteriovenous malformations (AVMs). " 06/01/1997 - "The goal was to determine the safety and efficacy of absolute ethyl alcohol treatment in the management of intra-axial brain arteriovenous malformations (AVMs). " 07/01/2023 - "In the present study, we summarize our experience in locating the nidus of arteriovenous malformations (AVMs) with a dominant outflow vein (DOV) in the lower extremities and eradicating the nidus with ethanol and coils. "
2.	Sirolimus (Rapamycin)FDA Link 11/01/2019 - "This study shows poor efficacy of sirolimus for treating extracranial arteriovenous malformations." 01/01/2020 - "Arteriovenous malformations were not improved by sirolimus. " 03/08/2022 - "Sirolimus used for treatment of retroperitoneal arteriovenous malformation in a premature neonate." 11/01/2019 - "Because of its anti-angiogenic properties here we report all extracranial arteriovenous malformation cases treated with sirolimus in 2 French tertiary centers for vascular anomalies. " 11/01/2019 - "Efficacy and Tolerance of Sirolimus (Rapamycin) for Extracranial Arteriovenous Malformations in Children and Adults."
3.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 10/27/2023 - "Case report: video-assisted thoracoscopic surgery for pulmonary arteriovenous malformation using near-infrared fluorescence with indocyanine green." 07/01/2023 - "Indocyanine green angiography revealed dilated, intensely fluorescent vessels in arterial phase emptying into massively dilated choroidal veins consistent with choroidal arteriovenous malformation. " 02/20/2023 - "As essential techniques, intraoperative indocyanine green video angiography (ICG-VA) and FLOW 800 have been widely used in microsurgery for arteriovenous malformations (AVMs). " 02/01/2023 - "To assess the utility of intraoperative indocyanine green video angiography (ICG-VA) during microsurgical resection of arteriovenous malformations (AVMs). " 03/01/2022 - "A case of arteriovenous malformation in the inferior mesenteric artery region resected surgically under intraoperative indocyanine green fluorescence imaging."
4.	Tissue Plasminogen Activator (Alteplase)FDA Link 06/01/2023 - "Intraventricular haemorrhage due to re-ruptured arteriovenous malformation cleared with tissue plasminogen activator administered through a pre-existing ventriculoperitoneal shunt." 04/01/2003 - "We present a case of IVH secondary to periventricular arteriovenous malformation (AVM) that was not visible at admission angiography and was treated by intraventricular infusion of recombinant tissue plasminogen activator before surgical intervention. " 01/01/1990 - "Ruptured arteriovenous malformation complicating thrombolytic therapy with tissue plasminogen activator." 04/01/2003 - "Recombinant tissue plasminogen activator is effective in resolving IVH causing obstructive hydrocephalus and uncontrollable ICP posing a life-threatening situation, secondary to ruptured arteriovenous malformation, before surgical intervention." 03/01/2014 - "Intraventricular tissue plasminogen activator for intraventricular hemorrhage caused by an arteriovenous malformation."
5.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/1999 - "Patients with pulmonary arteriovenous malformations should receive prophylactic antibiotic treatment before extractions, removal of third molars and subgingival curettage." 03/19/2021 - "We present the case of a 21-year-old patient with a right thalamic abscess due to HHT and pulmonary arteriovenous malformations, previously embolized, treated solely with antibiotics. " 12/15/2014 - "Potential significant changes in management included initiation of anticoagulation, placement of a patent foramen ovale (PFO) closure device, initiation of antibiotic therapy for endocarditis, surgical PFO closure, other cardiac surgery, and coil embolization of a pulmonary arteriovenous malformation. " 01/01/1996 - "Since no other infectious embolic sources were found and the patient's pulmonary infection was not extirpated by a prolonged course of antibiotics but only cured after surgical treatment of multiple periodontal abscesses, we speculate that gingival arteriovenous malformations being involved by periodontitis were the source of small septic emboli." 06/01/2011 - "She was initially misdiagnosed with a bleeding tumor or arteriovenous malformation rupture and treated without antibiotic therapy. "
6.	PicibanilIBA 07/01/2014 - "While there was limited evidence that sclerotherapy with OK-432 was an effective treatment for lymphatic malformations, evidence for the use of sclerotherapy in patients with arteriovenous malformations was unclear. " 02/01/2016 - "Our experience is that percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation is safe and effective. " 02/01/2016 - "Percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation."
7.	EnbucrilateIBA 08/01/2016 - "The purpose of the study was to evaluate the technique and outcomes of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate (NBCA) for the treatment of acquired uterine arteriovenous malformations (AVMs). " 07/01/2009 - "The aim of this study was to analyze the histopathological changes in a consecutive series of 32 patients with brain arteriovenous malformations that were resected after undergoing endovascular embolization (22 using Onyx and 10 using N-butyl cyanoacrylate [NBCA]). " 08/01/2023 - "N-butyl cyanoacrylate (NBCA) has been used to embolise brain arteriovenous malformations (AVMs) for over 30 years. " 02/01/2023 - "Ophthalmic artery occlusion following n-butyl cyanoacrylate embolization of an orbital arteriovenous malformation." 06/01/2020 - "N-butyl cyanoacrylate (NBCA) glue is a valuable liquid embolic agent for the endovascular treatment of brain arteriovenous malformations (BAVM). "
8.	IsotopesIBA 11/01/2005 - "The study goal is to enhance the efficacy of arteriovenous malformation embolization by adding a beta-emitting isotope to the embolic agent. " 07/01/1975 - "Scintillation camera studies of isotope flow in arteriovenous malformations." 01/01/1994 - "The 24 patients studied with the dual-isotope technique were evaluated during acetazolamide testing, trial balloon occlusion, or embolization of an arteriovenous malformation. "
9.	ethylene-vinyl alcohol copolymerIBA 08/01/2014 - "To document the efficacy of ethylene vinyl alcohol copolymer (ONYX; ev3/Covidien, Irvine, CA) in the treatment of arteriovenous malformations (AVMs) of the mandible. " 09/01/2022 - "PURPOSE This study aimed to evaluate the safety and outcome of image-guided embolization for treating arteriovenous malformations (AVMs) of the hand using ethylene-vinyl alcohol copolymer (EVOH). " 10/10/2023 - "To present a case of concurrent uterine arteriovenous malformation (AVM) and isthmocele, treated with ethylene vinyl alcohol copolymer (EVAC) embolization of the AVM followed by robotic isthmocele repair. " 03/01/2023 - "Novel use of precipitating hydrophobic injectable liquid (PHIL) in pre-operative angioembolisation of a large posterior auricular arteriovenous malformation." 09/01/2022 - "Image-guided embolization of arteriovenous malformations of the hand using Ethylene-vinyl Alcohol Copolymer."
10.	Gadolinium DTPA (Magnevist)FDA Link 11/01/1992 - "In the spine, T2-weighted images and MR-angiography were too insensitive to detect arteriovenous malformations, whereas gadolinium-DTPA first-pass studies sensitively detected the malformation and the changes after embolizations." 11/01/1992 - "The combination of T2-weighted images, MR angiography, and gadolinium-DTPA first-pass studies nicely demonstrated the arteriovenous malformations and the effect of embolisation which ranged from negligible to almost complete. " 12/01/1993 - "Gadolinium-DTPA enhanced magnetic resonance imaging of dural sinus occlusion in dural arteriovenous malformation: a case report." 04/01/1990 - "[A case of spinal dural arteriovenous malformation associated with the broad lesion within spinal cord--diagnostic value of MRI with Gd-DTPA enhancement]." 10/01/1989 - "(4) Gd-DTPA was found to be effective in enhancing MRI in all cases of spinal cord tumors with exception of two cases of arteriovenous malformations. "

Therapies and Procedures

1.	Therapeutics 08/01/2015 - "Endovascular therapy has been shown to be beneficial in patients with high surgical risks and is the treatment of choice for arteriovenous malformation lesions that extend beyond the deep fascia and involve muscle, tendon, and bone. " 04/01/2020 - "There is a lack of consensus in the management of arteriovenous malformations (AVMs) of the brain since ARUBA (A Randomised trial of Unruptured Brain Arteriovenous malformations) trial showed that medical management is superior to interventional therapy in patients with unruptured brain AVMs. " 11/01/2018 - "The results of the A Randomized Trial of Unruptured Brain Arteriovenous (ARUBA) study, indicating that conservative medical management of unruptured brain arteriovenous malformations (UBAVM) is superior to interventional therapy, have generated debates that have hampered their application into clinical practice. " 03/01/2017 - "The ARUBA trial (2014) concluded that medical management alone is superior to medical management plus interventional therapy for the treatment of unruptured brain arteriovenous malformations (bAVMs). " 01/01/2019 - "To confirm or repudiate the ARUBA conclusion that "medical management only is superior to medical management with interventional therapy for unruptured brain arteriovenous malformations." Data were collected from 1351 patients treated with Gamma Knife Surgery (GKS; Elekta AB, Stockholm, Sweden) for unruptured and untreated AVMs The follow-up was 8817 yr (median 5.0 and mean 6.5). "
2.	Therapeutic Embolization 11/01/2000 - "To assess the long-term efficacy of embolotherapy in combination with surgery for management of symptomatic high-flow arteriovenous malformations (HFAVMs) of the lower and upper extremities. " 04/01/1983 - "Balloon embolotherapy provided an effective treatment for pulmonary arteriovenous malformations regardless of anatomic type." 02/01/2001 - "Transcatheter embolotherapy of maternal pulmonary arteriovenous malformations performed by an experienced radiologist appears to be safe and effective after 16 weeks of gestational age." 02/01/2001 - "To determine if transcatheter embolotherapy is safe and effective for the treatment of pulmonary arteriovenous malformations during pregnancy. " 06/01/2012 - "To retrospectively evaluate the efficacy of embolotherapy in patients with iatrogenic traumatic uterine arteriovenous malformations (AVMs). "
3.	Catheters 05/01/1994 - "For safe, more definitive embolisation of arteriovenous malformations, improved selectivity of the catheter is desirable. " 12/01/2020 - "Although some potential complications need to be considered, the S-shaped distal access catheter technique appears to be an effective alternative approach to gaining access to difficult feeders of arteriovenous malformations." 06/01/2020 - "To compare the performance of arterial spin labelling (ASL) in evaluating arteriovenous malformations (AVMs) against the current gold standard of catheter angiography. " 05/01/2008 - "To evaluate the feasibility and efficacy of a modified metallic coil embolization technique for pulmonary arteriovenous malformations (PAVMs) using coil anchors and occlusion balloon catheters. " 06/01/2019 - "The primary endpoint of the trial is complete arteriovenous malformation occlusion, assessed by catheter cerebral angiography. "
4.	Sclerotherapy 06/01/2023 - "To evaluate the efficacy and safety of embolo-sclerotherapy (EST) particularly with foamed sclerotherapy in the treatment of arteriovenous malformations (AVMs). " 01/01/2023 - "To retrospectively report our preliminary experience of treating hand arteriovenous malformations (AVMs) with embolo/sclerotherapy. " 01/01/2023 - "Embolo/sclerotherapy for the treatment of hand arteriovenous malformations: a single-center retrospective cohort experience." 03/01/2022 - "A 26-year-old male was referred to the department of interventional radiology for sclerotherapy of an aggravating large facial arteriovenous malformation (AVM). " 08/01/2021 - "Giant parapharyngeal high-flow arteriovenous malformation causing airway compromise: emergency embolo-sclerotherapy via an endovascular-only approach."
5.	Aftercare (After-Treatment) 12/01/2023 - "A compact nidus is a well-known feature of good outcome after treatment in brain arteriovenous malformations (bAVM). " 03/01/2023 - "Digital subtraction angiography remains the gold standard for assessing symptomatic and aggressive arteriovenous malformations, both before and after treatment. " 07/01/2021 - "Postoperative digital subtraction angiography (DSA) is the gold standard for establishing a cure of an arteriovenous malformation (AVM) after treatment. " 01/01/2022 - "Seizure control after stereotactic radiosurgery (SRS) for arteriovenous malformations (AVMs) is an area of growing interest, with previous studies reporting up to 70% seizure freedom after treatment. " 10/01/2023 - "To estimate the diagnostic value of contrast-enhanced MR angiography (CE-MRA) in identifying residual brain arteriovenous malformations (AVMs) after treatment. "