Sinus Arrhythmia

Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.

Also Known As:

Networked: 115 relevant articles (4 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tachycardia (Tachyarrhythmias)
2.	Myocardial Ischemia (Ischemic Heart Diseases)
3.	Bradycardia
4.	Atrioventricular Block
5.	Ventricular Premature Complexes (Premature Ventricular Contraction)

Experts

1.	Biaggioni, Italo: 3 articles (01/2021 - 07/2003)
2.	Black, Bonnie K: 2 articles (01/2021 - 01/2020)
3.	Garland, Emily M: 2 articles (01/2021 - 01/2020)
4.	Lannes-Vieira, Joseli: 2 articles (01/2019 - 10/2016)
5.	Ramos, Isalira P: 2 articles (01/2019 - 10/2016)
6.	Vilar-Pereira, Glaucia: 2 articles (01/2019 - 10/2016)
7.	Markos, F: 2 articles (10/2001 - 09/2001)
8.	Snow, H M: 2 articles (10/2001 - 09/2001)
9.	Basel-Salmon, Lina: 1 article (01/2022)
10.	Bazak, Lily: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sinus Arrhythmia:

1.	ResveratrolIBA 10/01/2016 - "Resveratrol reduced the prolonged PR and QTc intervals, increased heart rates and reversed sinus arrhythmia, atrial and atrioventricular conduction disorders; restored a normal left ventricular ejection fraction, improved stroke volume and cardiac output. "
2.	4- (4- (3- (pyridin- 2- yl)- 1H- pyrazol- 4- yl)pyridin- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)benzamideIBA 01/01/2019 - "The treatment with GW788388 improved several cardiac parameters: reduced the prolonged PR and QTc intervals, increased heart rate, and reversed sinus arrhythmia, and atrial and atrioventricular conduction disorders. "
3.	esmolol (Brevibloc)FDA LinkGeneric 01/01/1986 - "Whereas beta blockers in general are effective in settings of supraventricular arrhythmias, sinus tachycardia, and myocardial ischemia, esmolol provides the added dimension of "titratability." Thus, the short duration of action of esmolol allows for very rapid titration to a preferred steady-state level of beta blockade; rapid adjustment to different steady-state levels of beta blockade, as may be required by changing status of the patient, and rapid disappearance of beta blockade following discontinuation of esmolol infusion, should this be necessary in the event of deleterious cardiac hemodynamic effects. "
4.	AtropineFDA LinkGeneric 01/01/1991 - "Dose/response studies in humans and rhesus monkeys are cited as an example for interspecies comparisons using ED50 calculations for a 30% decrease in the respiratory sinus arrhythmias following atropine. " 06/01/1993 - "Following the creation of a computerised tool enabling not only the entry of indirect tests, processing, averaging of results, printing and memorization, but also assistance in interpretation, several electrophysiological parameters were used: heart rate and existence of sinus arrhythmia, Strauss tests with adjusted data or not, effective nodal refractory period, Guize, Narula and Mandel tests, and an atropine (0.03 mg/kg) test which was performed only in the symptomatic group. " 01/01/1991 - "Respiratory sinus arrhythmias are quantified following atropine sulfate administration and the resulting vagolytic blockade is used as a pharmacologic challenge technique. " 02/01/1984 - "Low-dose atropine together with face immersion further augmented blood pressure, heart period, baroreflex responses and sinus arrhythmia. " 03/01/1983 - "Large dose atropine reduced sinus arrhythmia and baroreflex responses in an exponential fashion. "
5.	CytokinesIBA 12/01/2016 - "In this study, we were focused on the differences between certain circulating cytokine levels in patients with or without sinus arrhythmia, according to the median IL-6 level. " 12/01/2016 - "Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease."
6.	Interleukin-6 (Interleukin 6)IBA 12/01/2016 - "It is possible that IL-6 may not be a marker for the selection of patients with sinus arrhythmia or coronary artery disease. " 12/01/2016 - "In this study, we were focused on the differences between certain circulating cytokine levels in patients with or without sinus arrhythmia, according to the median IL-6 level. " 12/01/2016 - "Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease." 12/01/2016 - "The findings indicate that IL-6 represents a reliable indicator for increased expression of IL-2, IL-8, IL-10, IL-17 and IL-18 in patients with sinus arrhythmia or coronary artery disease. "
7.	Indicators and Reagents (Reagents)IBA 01/01/1986 - "[Sinus arrhythmia as an indicator of mental stress: quantification by time]." 03/01/1984 - "Acute sinus arrhythmia during surgery in the fourth ventricle: an indicator of brain-stem irritation." 04/01/1996 - "Ventilator-associated sinus arrhythmia in a preterm neonate--an indicator for a mature autonomic nervous system?" 12/01/2016 - "The findings indicate that IL-6 represents a reliable indicator for increased expression of IL-2, IL-8, IL-10, IL-17 and IL-18 in patients with sinus arrhythmia or coronary artery disease. "
8.	MedetomidineIBA 07/01/1996 - "All treatments resulted in a significant decrease in HR. Four dogs receiving epidural medetomidine each had second degree atrioventricular (AV) block associated with sinus arrhythmia for a brief period during the first 20 minutes after injection. " 02/10/1996 - "Medetomidine resulted in marked bradycardia, lasting as long as the sedation and the ECG revealed a sinus arrhythmia with sinoatrial and atrioventricular blocks grade I and II as a sign of interference with transduction. " 01/01/1989 - "Atropine prevented the profound bradycardia and sinus arrhythmia seen with medetomidine alone. "
9.	Xylazine (Xylazin)IBA 01/15/1985 - "An IV injection of xylazine (1 mg/kg) caused a decrease in HR, which was accompanied by sinus arrhythmia. " 09/01/1985 - "A pronounced sinus arrhythmia and/or 2nd-degree atrioventricular block developed in all dogs during xylazine injection after saline infusion. " 01/15/1981 - "Xylazine and sinus arrhythmia, first and second degree atrioventricular block and paroxysmal left ventricular tachycardia."
10.	Polyvinyl Chloride (PVC)IBA 06/29/2018 - "(4) Determination of the PVC patterns, if present, to categorize distinct types of sinus arrhythmias and NSR. " 11/01/1995 - "Certain arrhythmias are frequently noted in normal healthy adults, including sinus bradycardia, sinus arrhythmia, the Wenckebach type of second-degree AV block (Mobitz I), atrioventricular junctional rhythm, PAC's, and PVC's. " 07/01/2008 - "Of 1,221 patients undergoing 64-row multidetector-row computed tomography coronary angiography (coronary MDCT), 123 patients (28 atrial fibrillation (Af), 39 premature atrial contractions (PAC), 42 premature ventricular contractions (PVC), 3 PAC + PVC, 10 sinus arrhythmias (SA), and a second-degree atrioventricular block (2 degrees AVB)) had arrhythmias necessitating the ECG-edit function. "

Therapies and Procedures

1.	Denervation 07/28/1998 - "Vagally modulated sinus arrhythmia and BRS were also eliminated after chronic vagal denervation. "
2.	Catheter Ablation 01/01/2022 - "The present study aimed to investigate whether different preoperative left atrial appendage emptying speeds (LAAEVs) have an effect on left atrial function in patients with sinus arrhythmia after left atrial appendage closure (LAAC) combined with catheter ablation (CA). "
3.	Therapeutics 08/03/2015 - "The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to generation of potential therapies, such as biological pacemakers, for sinus arrhythmias. " 01/01/2008 - "The method of 24-hour HRV analysis based on assessment of dependence of the value of sinus arrhythmia on HR is useful in evaluating the effectiveness of anti-hypertension therapy. " 11/01/2017 - "Benign arrhythmias include sinus arrhythmia, premature atrial contraction, premature ventricular contraction, and junctional rhythm; these arrhythmias have no clinical significance and do not need therapy. " 08/01/1985 - "The cardiac arrhythmias due to vagal tone (sinus arrhythmia, sinus block, sinus arrest, sinus bradycardia, wandering pacemaker, first-degree AV block, and second-degree AV block) that are found in resting horses are generally considered to be normal and generally do not require therapy." 09/01/1980 - "Intravenous infusion of 10% calcium chloride solution following transfusion therapy leads to marked diminution of tachycardia, restoration of sinus arrhythmia, decrease of general peripheral resistance, reduction of the capacity of the venous bed, acceleration of the blood flow rate, and normalization of the central mechanisms of cardiac activity regulation. "
4.	Drug Therapy (Chemotherapy) 05/01/1993 - "The symptoms originating from drug therapy were dominated by sinus arrhythmias (25 cases), linked to drugs co-administered that have potentially similar cardiac pharmacodynamic effects. " 10/01/2022 - "Overall, this represents a rare case of sinus arrhythmia in NSCLC patient during the first cycle of combined chemotherapy with pemetrexed and carboplatin. "
5.	Percutaneous Coronary Intervention 10/22/2020 - "She had undergone percutaneous coronary intervention and pacemaker implantation to treat acute coronary syndrome and sinus arrhythmia, respectively. "