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Aromatase (CYP19)

An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Also Known As:
CYP19; Androstenedione Aromatase; CYP 19; CYP19 Protein; Cytochrome P450 19; Estrogen Synthase; Estrogen Synthetase; P450AROM; Aromatase, Androstenedione; Cytochrome P 450 CYP19; Protein, CYP19; Cytochrome P-450 CYP19; Cytochrome P-450(AROM)
Networked: 3173 relevant articles (196 outcomes, 644 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sasano, Hironobu: 65 articles (11/2015 - 01/2002)
2. Chen, Shiuan: 54 articles (07/2015 - 04/2002)
3. Suzuki, Takashi: 46 articles (10/2015 - 01/2002)
4. Simpson, Evan R: 40 articles (12/2015 - 01/2002)
5. Miki, Yasuhiro: 40 articles (11/2015 - 01/2005)
6. Bulun, Serdar E: 39 articles (05/2015 - 03/2002)
7. Dowsett, Mitch: 25 articles (01/2015 - 01/2002)
8. Brueggemeier, Robert W: 25 articles (02/2012 - 02/2002)
9. Evans, Dean B: 25 articles (05/2011 - 07/2005)
10. Brodie, Angela: 24 articles (11/2015 - 03/2002)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Neoplasms (Cancer)
3. Endometriosis (Adenomyosis)
4. Carcinoma (Carcinomatosis)
5. Pain (Aches)

Related Drugs and Biologics

1. Hormones
2. letrozole (Femara)
3. Estrogens (Estrogen)
4. anastrozole (Arimidex)
5. Tamoxifen
6. exemestane (Aromasin)
7. Aromatase Inhibitors
8. Estrogen Receptor Modulators (Antiestrogen)
9. Enzymes
10. Aromatase (CYP19)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Chemoprevention
4. Ovariectomy (Oophorectomy)
5. Oral Administration