Aroclors

Industrial chemicals which have become widespread environmental pollutants. Each aroclor is a mixture of chlorinated biphenyls (1200 series) or chlorinated terphenyls (5400 series) or a combination of both (4400 series).

Also Known As:

Networked: 64 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thomas, Peter: 2 articles (04/2018 - 01/2011)
2.	Shen, Wei: 1 article (08/2020)
3.	Wang, Wei: 1 article (08/2020)
4.	Yin, Shen: 1 article (08/2020)
5.	Zhao, Minghui: 1 article (08/2020)
6.	Zhao, Yong: 1 article (08/2020)
7.	Rahman, Md Saydur: 1 article (04/2018)
8.	Cao, Meng: 1 article (01/2018)
9.	Cheng, Xiaodong: 1 article (01/2018)
10.	Fan, Junshu: 1 article (01/2018)

Related Diseases

1.	Insulin Resistance 01/01/2018 - "Downregulation of HNF1b inhibited OA-induced protective effects against Aroclor 1254-associated oxidative stress, adipocyte differentiation and insulin resistance. " 01/01/2018 - "The present study aimed to investigate the effect of OA on Aroclor 1254-induced adiposity and insulin resistance and explore the possible involvement of HNF1b. " 01/01/2018 - "Upregulation of HNF1b blocked Aroclor 1254-induced oxidative stress, adipocyte differentiation and insulin resistance. " 02/01/2016 - "Aroclor exposure improved insulin sensitivity in WT mice but not glucose tolerance. " 01/01/2018 - "We showed that OA significantly attenuated Aroclor 1254-induced insulin resistance and abnormal changes of glucose and lipid parameters. "
2.	Teratogenesis 08/01/1991 - "As part of a programme of improvement in the safety of potatoes using molecular plant genetics and parallel food safety evaluation, we evaluated the effect of several potato glycoalkaloids and aglycones in the frog embryo teratogenesis assay--Xenopus (FETAX) with and without metabolic activation by Aroclor 1254-induced rat liver microsomes. " 12/01/1995 - "In previous studies a metabolic activation system (MAS) composed of Aroclor 1254-induced rat liver microsomes led to an apparent reduction of potato glycoalkaloid developmental toxicity in the frog embryo teratogenesis assay-Xenopus (FETAX). "
3.	Neoplasms (Cancer) 01/01/2009 - "Aroclors) did not pose a cancer risk to humans ( Golden et al. (2003) . " 01/01/1998 - "A significantly decreased trend in the incidence of mammary gland neoplasms compared to control was also noted for females receiving Aroclors 1242, 1254, and 1260." 11/01/1995 - "Dietary Aroclor significantly promoted liver tumors in C57BL/6 mice (59 versus 14%) but not in B6D2F1 mice (24 versus 21%). " 11/01/1995 - "Aroclor caused an 8-fold induction of hepatic Cyp 2b, which was its maximum at the 12-week time point but did not promote tumors. " 11/01/1994 - "Analytical chemistry was used to quantitate the amount of Aroclor per tumor cell population and compared directly to flow cytometric results. "
4.	Hepatocellular Carcinoma (Hepatoma) 02/01/1996 - "In order to determine the role of biotransformation in the tumor-promoting activity of PB, its effect on GJIC was also examined in the presence of an Aroclor 1254-induced rat liver homogenate (S9 mix) and in the hepatoma cell line HepG2. " 03/01/1993 - "The cytotoxicity of eugenol to human HFF fibroblasts and human HepG2 hepatoma cells was increased somewhat in the presence of a hepatic S-9 microsomal fraction from Aroclor-induced rats or hamsters. " 11/01/1977 - "At the end of the year, 26 of 37 (70.3%) trout fed 6 ppb AFB1 had hepatocellular carcinomas, compared to 14 of 46 (30.4%) trout fed 6 ppb AFB1 plus 100 ppm Aroclor 1254, a highly significant reduction in tumor incidence in the trout on the Aroclor 1254-containing diet. " 07/01/1982 - "Four Aroclor reference materials, cleaned-up extracts of 2 yusho rice oil samples, and cleaned-up extracts of 3 fish samples containing polychlorinated biphenyl (PCB) residues were tested for their ability to induce aryl hydrocarbon hydroxylase (AHH) activity in a rat hepatoma cell line. "
5.	Lymphoma (Lymphomas) 07/01/2008 - "NTA was assayed in the Ames test using TA1537, TA98, TA100, and TA102 tester strains, and in the in vitro micronucleus assay on L5178Y mouse lymphoma cells and on CTLL2 and CTLL2/Bcl2 cells coupled to the apoptosis measurement, both with and without metabolic activation by aroclor 1254-induced liver or kidney rat S9-mix. " 01/01/2000 - "Both DMP and DBP were found to produce significant increases in the mutant frequency in the mouse lymphoma assay in the presence but not in the absence of an Aroclor-induced rat liver activation system (S-9). " 01/01/1987 - "Oxytetracycline hydrochloride was mutagenic in L5178Y/TK+/- mouse lymphoma cells in the presence but not in the absence of Aroclor 1254-induced male rat liver S9. " 01/01/1987 - "Pentachloronitrobenzene was not mutagenic at the TK+/- locus of L5178Y mouse lymphoma cells in the presence or absence of Aroclor 1254-induced F344/N rat liver S9. " 08/01/1986 - "Benzyl acetate was mutagenic in the mouse lymphoma L5178Y/TK± assay in the presence, but not in the absence, of Aroclor 1254-induced Fisher 344 rat liver S9. "

Related Drugs and Biologics

1.	Chlorodiphenyl (54% Chlorine)
2.	Glucose (Dextrose)
3.	Vitamin A (Retinol)
4.	Thymidine Kinase
5.	Mutagens
6.	Chlordan (Chlordane)
7.	Hexachlorocyclohexane (gamma-Hexachlorocyclohexane)
8.	Polychlorinated Biphenyls (PCBs)
9.	Aroclors
10.	Cytochrome P-450 CYP1A1 (CYP1A1)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Aftercare (After-Treatment)