|1.||Savaraj, Niramol: 7 articles (03/2015 - 01/2007)|
|2.||Szlosarek, Peter W: 7 articles (02/2014 - 12/2006)|
|3.||Kung, Hsing-Jien: 6 articles (09/2014 - 10/2008)|
|4.||Saheki, Takeyori: 6 articles (10/2005 - 12/2002)|
|5.||Kobayashi, Keiko: 6 articles (10/2005 - 12/2002)|
|6.||Bomalaski, John S: 5 articles (08/2015 - 10/2002)|
|7.||Feun, Lynn G: 5 articles (03/2015 - 08/2010)|
|8.||Kuo, Macus Tien: 5 articles (03/2015 - 12/2009)|
|9.||Bold, Richard J: 5 articles (09/2014 - 10/2008)|
|10.||Frankel, Arthur E: 4 articles (12/2014 - 01/2012)|
04/01/2002 - "Structure of the human argininosuccinate synthetase gene and an improved system for molecular diagnostics in patients with classical and mild citrullinemia."
03/01/2005 - "Previous studies showed short-term correction of bovine and murine argininosuccinate synthetase (ASS) deficiency after first generation adenoviral-mediated liver gene therapy. "
01/01/1979 - "Studies on liver argininosuccinate synthetase in a patient with citrullinemia and in normal subjects."
01/01/2015 - "Case 1 has a triplication at 9q21.11-q21.33 and segmental paternal isoUPD for 9q21.33-qter, and presented with citrullinemia with a homozygous mutation in the argininosuccinate synthetase gene (ASS1 at 9q34.1). "
11/01/2014 - "The authors present a case of citrullinemia with a genotype of argininosuccinate synthetase (ASS1), c.380 G>A (p.R127Q)/c.380 G>A (p.R127Q), in two alleles. "
01/01/2015 - "New developments in this area include understanding of the role of most significantly downregulated gene regulating amino acid metabolism, argininosuccinate synthetase and its expression and therapeutic relevance in different tumors. "
12/01/2014 - "Unfortunately, after 1 month, half of the relapsing tumors showed argininosuccinate synthase induction, which correlated with Ser62-phosphorylated cMyc. "
11/01/2006 - "Both bioconjugates exhibited potent growth inhibition of several cultured tumor lines that are deficient in the anabolic enzyme, argininosuccinate synthetase. "
01/01/2015 - "Aberrant expression of argininosuccinate synthetase (ASS1, also known as ASS) has been found in cancer cells and is involved in the carcinogenesis of gastric cancer. "
04/01/2014 - "Argininosuccinate synthetase 1 (ASS1) is a key enzyme in arginine biosynthesis, and its abundance is reduced in many solid tumors, making them sensitive to external arginine depletion. "
|3.||Melanoma (Melanoma, Malignant)
09/01/1992 - "Five melanoma cell lines tested also exhibited reduced argininosuccinate synthetase (ASS) gene expression--being almost absent in four cell lines and at low level in one cell line. "
01/01/2013 - "Melanoma cells frequently lack argininosuccinate synthetase, an essential enzyme for arginine synthesis, and as a result they become dependent on the availability of exogenous arginine. "
05/15/2012 - "Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells."
04/24/2012 - "Advanced melanoma patients with accessible tumours had biopsy performed before the start of treatment with ADI-PEG20 and at the time of progression or relapse when amenable to determine whether argininosuccinate synthetase (ASS) expression in tumour was predictive of response to ADI-PEG20. "
12/01/2009 - "The sensitivity of melanoma to ADI treatment is based on its auxotrophy for arginine due to a lack of argininosuccinate synthetase (AS) expression, the rate-limiting enzyme for the de novo biosynthesis of arginine. "
|4.||Liver Diseases (Liver Disease)
|5.||Hepatocellular Carcinoma (Hepatoma)
01/01/2015 - "Expression profile and down-regulation of argininosuccinate synthetase in hepatocellular carcinoma in a transgenic mouse model."
02/01/2013 - "Expression of argininosuccinate synthetase in patients with hepatocellular carcinoma."
06/01/2011 - "Combined lysosomal protein transmembrane 4 beta-35 and argininosuccinate synthetase expression predicts clinical outcome in hepatocellular carcinoma patients."
09/28/2010 - "Human hepatocellular carcinoma (HCC) cells are largely deficient of argininosuccinate synthetase and thus auxotrophic for arginine. "
05/01/2010 - "It is well known that hepatocellular carcinoma (HCC) is an arginine auxotroph due to argininosuccinate synthetase I deficiency. "
|6.||Protein Isoforms (Isoforms)
|9.||Messenger RNA (mRNA)
|1.||Drug Therapy (Chemotherapy)