Arbutin

04/30/2016 - "This article explores the utilization of micellar transdermal delivery technology to improve skin penetration and efficacy of arbutin, a hyperpigmentation agent. "
10/01/2022 - "The purpose of this study was to evaluate the depigmenting effect of CREO on genital hyperpigmentation to that of arbutin (ARB), and to evaluate the association between genital lightening, genital self-image, sexual performance, and life quality. "
05/01/2021 - "The findings of this work discovered that the manufactured arbusome could be utilized as possible nano-vehicle for the arbutin topical delivery and might open new approaches for the treatment of hyperpigmentation complaints."
01/01/2020 - "Arbutin is of interest because of its skin-lightening effect, and used in cosmetic products for cutaneous hyperpigmentation. "
07/01/2017 - "Bearberry leaves contain arbutin, a skin-lightening agent that is an alternative for the treatment of hyperpigmentation. "

01/01/2021 - "Formulation and Pharmaceutical Evaluation of Extemporaneous α-arbutin Creams for the Treatment of Melasma."
06/01/2010 - "Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: a prospective study."
09/01/2008 - "Efficiency of ellagic acid and arbutin in melasma: a randomized, prospective, open-label study."
01/01/2021 - "Concentrated 7% w/w a-arbutin cream was formulated and evaluated using O/W and W/O emulsion bases as an extemporaneous preparation for melasma treatment. "
06/01/2010 - "Combination therapy with the MedLite C6 and 7% alpha arbutin solution is an effective and well-tolerated treatment for refractory melasma."

12/01/2021 - "This study was intended to investigate the protective effects and mechanisms of arbutin on DSS-induced colitis. "
01/01/2021 - "Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway."
01/01/2021 - "The study aimed to investigate the effects and mechanisms of regulating JAK2 by arbutin on colitis in mice. "
01/01/2021 - "Conclusion: The findings obtained herein suggest the protective role of arbutin and provide novel insights into alternative colitis treatments, which involve inhibition of the JAK2 signaling pathway."
01/01/2021 - "High expression of phosphorylated JAK2 in colitis was significantly reversed by arbutin. "

11/01/2018 - "Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease."
01/01/2020 - "α-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo."
11/01/2018 - "The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinson's disease (PD). "
12/01/2021 - "Recently, arbutin showed benefits in animal models of epilepsy, Parkinson's disease, and Alzheimer's disease that further expanded its therapeutic potential against brain disorders. "
10/01/2021 - "Arbutin effectively ameliorates the symptoms of Parkinson's disease: the role of adenosine receptors and cyclic adenosine monophosphate."

01/01/2021 - "Arbutin ameliorates glucocorticoid-induced osteoporosis through activating autophagy in osteoblasts."
01/01/2021 - "Taken together, our findings suggest that arbutin treatment fends off glucocorticoid-induced osteoporosis, partly through promoting differentiation and mineralization of osteoblasts by autophagy activation."
01/01/2021 - "However, the role and underlying mechanism of arbutin in glucocorticoid-induced osteoporosis are elusive. "
08/01/2021 - "A review of recent studies showed that arbutin could be beneficial in treatment of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes, etc. This study was designed to describe the therapeutic efficiencies of arbutin."
07/01/2015 - "These results suggest that rosmarinic acid and arbutin may be useful for the prevention and treatment of bone diseases, such as osteoporosis, through mechanisms involving inhibition of superoxide and downregulation of NFATc1."